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An organically encapsulated magnetic nanoparticle composite bone scaffold and its preparation method

A magnetic nanoparticle and magnetic nanoparticle technology, applied in the field of material manufacturing, can solve the problems of cell response limitation, lack of osteoinductivity, poor hydrophobicity, etc., and achieve the effect of improving mechanical properties, enhancing mechanical properties, and enhancing adhesion

Inactive Publication Date: 2021-01-01
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PEEK lacks osteoinductivity as an artificial bone material, and its hydrophobicity and poor cell response limit its application in bone grafting.

Method used

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  • An organically encapsulated magnetic nanoparticle composite bone scaffold and its preparation method
  • An organically encapsulated magnetic nanoparticle composite bone scaffold and its preparation method
  • An organically encapsulated magnetic nanoparticle composite bone scaffold and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Nano-Fe 3 o 4 (Particle size is 20nm) / Add to the mixed solution containing 50mL of absolute ethanol and 50mL of deionized water, ultrasonically disperse for 30 minutes, transfer the solution to a magnetic stirrer, pass through nitrogen protection, when the temperature rises to 80°C, Add 5 mL of oleic acid and stir at 80°C for 1 hour. After the temperature is cooled to room temperature, wash with distilled water three times to remove excess oleic acid and obtain oleic acid-modified Fe 3 o 4 Powder (o-Fe 3 o 4 ).

[0052] (2) Pre-weighed dry o-Fe 3 o 4 The powder is in 20 times the volume of chloroform, and the suspension is added to 4wt.% PEEK (purity is 99.9%, particle size is 20 μm) / chloroform solution to obtain o-Fe 3 o 4 A mixture with a content of 2.5wt.% (o-Fe 3 o 4 powder and PEEK powder mass ratio 0.025:0.975), the composite powder was further ultrasonicated for 1 hour, and finally the mixed powder was dried in a vacuum oven at room temperature for ...

Embodiment 2

[0056] Compared with Example 1, the difference is that the amount of magnetic nanoparticles in the bone scaffold is reduced:

[0057] (1) Nano-Fe 3 o 4 (Particle size is 2nm) / Add to the mixed solution containing 50mL of absolute ethanol and 50mL of deionized water, ultrasonically disperse for 30 minutes, transfer the solution to a magnetic stirrer, pass through nitrogen protection, when the temperature rises to 80°C, Add 5 mL of oleic acid and stir at 80°C for 1 hour. After the temperature is cooled to room temperature, wash with distilled water three times to remove excess oleic acid and obtain oleic acid-modified Fe 3 o 4 Powder (o-Fe 3 o 4 ).

[0058] (2) Pre-weighed dry o-Fe 3 o 4 The powder is in 20 times the volume of chloroform, and the suspension is added to 4wt.% PEEK (purity is 99.9%, particle size is 20 μm) / chloroform solution to obtain o-Fe 3 o 4 The content of 0.5wt.% mixture (o-Fe 3 o 4 powder and PEEK powder mass ratio 0.005:0.995), the composite powd...

Embodiment 3

[0062] All the other conditions are consistent with Example 1, the difference is that o-Fe 3 o 4 The content of the mixture is 12wt.% (o-Fe 3 o 4 Powder and PEEK powder mass ratio 0.12:0.88).

[0063] Microstructural tests found that 12wt% Fe 3 o 4 Dispersed in the PEEK matrix, the agglomeration phenomenon is serious. Mechanical properties tests found that PEEK / Fe 3 o 4 The tensile strength of the scaffold is 66MPa and the compressive strength is 52MPa. The MTT test found that the 12wt% composite scaffold proliferated by 87% relative to the cathode control group. Compared with Example 1, the mechanical properties are poor because the Fe after oleic acid modification 3 o 4 The content is more than that of Example 1, serious agglomeration occurs, and the strengthening effect is limited. More magnetic nanoparticles promote cell proliferation, thus exhibiting a higher cell proliferation rate.

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Abstract

The invention belongs to the field of a bone bracket material, and particularly discloses an organic-encapsulated magnetic nanoparticle composite bone bracket. The organic-encapsulated magnetic nanoparticle composite bone bracket is prepared by selective laser sintering on mixed raw materials containing organic-modified magnetic nanoparticles and polymers arranged in the mixed raw materials, wherein the organic-modified magnetic nanoparticles comprise magnetic nanoparticles and an organic compound coating the surfaces of the magnetic nanoparticles. The inventor creatively finds that the organic compound encapsulated magnetic nanoparticles and the polymers have obvious cooperativity, and by a selective laser sintering method, the properties of the bone bracket can be obviously improved, forexample, the hydrophobicity of the bone bracket can be improved, and the stretching and compressing strength can be improved. In addition, the biocompatibility can also be improved, and properties ofskeleton growth and the like can be improved.

Description

technical field [0001] The invention belongs to the field of material manufacturing; in particular, it relates to a bone support material. Background technique: [0002] In recent years, the number of cases of bone defects caused by accidents and bone diseases has increased year by year. Bone grafting is the main method for treating bone defects, including autologous bone grafting, allogeneic bone grafting and artificial bone grafting. Autologous bone transplantation is considered to be the gold standard for the treatment of bone defects, but there are disadvantages such as limited materials, increased surgical trauma, and easy to cause complications at the bone harvesting site. The source of allogeneic bone transplantation is rich, but there is immune rejection and the survival rate is low. , and prone to problems such as disease transmission and cross-infection. Artificial bone grafts have attracted widespread attention due to the advantages of wide material sources, goo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/58B33Y10/00B33Y70/10
CPCA61L27/44A61L27/446A61L27/50A61L27/58A61L2300/412A61L2400/12A61L2430/02B33Y10/00B33Y70/00C08L61/16
Inventor 帅词俊冯佩
Owner CENT SOUTH UNIV
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