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Portable NO production machine

A nitric oxide and manufacturing machine technology, which is applied in the field of medical devices, can solve problems such as potential safety hazards, and achieve the effects of low maintenance costs, safe and reliable raw materials, and easy maintenance

Pending Publication Date: 2020-03-10
南京诺令生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nitric oxide obtained by these methods contains a considerable amount of poisonous nitrogen dioxide gas, which poses a very large safety hazard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]Specifically, the solution used for electrochemically generating nitric oxide is a buffer solution containing 1M sodium nitrite and 7mM copper catalyst. Electrode material: soft stainless steel mesh; working electrode×reference electrode: 9cm×3cm; the nitrogen outlet is juxtaposed with the negative electrode of the electrode, and the nitric oxide adsorbed on the surface of the electrode and dissolved in the solution is separated and taken away from the reaction vessel, and is oxidized by nitrogen Analyzer for detection.

[0032] The flow rate of nitrogen gas was controlled to be 0.7 L / min, and no current was applied. At this time, the detection concentration of nitric oxide was 4.5 ppm (Table 1).

[0033] Change the magnitude of the applied current (1-5mA), at this time, the detection concentration of nitric oxide increases linearly, and the growth rate is about 16.8ppm / mA. Under the action of 5mA current, the concentration of nitric oxide is as high as 86.8ppm.

[0034...

Embodiment 2

[0037] Specifically, the electrolyte is a buffer solution containing 1M sodium nitrite and 7mM copper catalyst. Electrode material: gold-plated soft stainless steel mesh; working electrode × reference electrode: 9cm × 3cm.

[0038] Control the flow rate of nitrogen to 0.7L / min, choose gold-plated soft stainless steel mesh as the working electrode, change the magnitude of the action current (1~5mA), the concentration of nitric oxide increases linearly, and the growth rate is about 17.5ppm / mA. The nitrogen concentration was as high as 93.3 ppm (Table 2). Compared with the soft stainless steel mesh, the concentration of nitric oxide has increased to a certain extent.

[0039] Table 2. Changes of nitric oxide (NO) concentration with current

[0040]

Embodiment 3

[0042] Specifically, the electrolyte is a buffer solution containing 1M sodium nitrite and 7mM copper catalyst. Electrode material: soft stainless steel mesh; working electrode×reference electrode: 9cm×3cm; the total flow rate of the control gas is 0.7L / min, the solution is purged with nitrogen, and the mixing ratio of nitrogen and air is changed, and the gas outlet is juxtaposed with the negative electrode of the electrode , the nitric oxide adsorbed on the surface of the electrode and dissolved in the solution is separated and taken away from the reaction vessel, and detected by a nitric oxide gas analyzer.

[0043] Control the total gas flow rate to 0.7L / min, and fix the mixing ratio of nitrogen and air (R(N 2 / Air) can be 2, 1, 0.5), at this time, the detected concentration of NO increases linearly with the increase of current.

[0044] Change the mixing ratio of nitrogen and air (R(N 2 / Air) take 2, 1, 0.5), at this time, the detection concentration of NO increases with...

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Abstract

The invention discloses a portable NO production machine including: an air pump, a NO generator, and a reduction module. The NO generator is connected to a NO concentration regulator and a digital display. Through electrochemical principle of NO generation, fresh NO is prepared. The raw materials are safe and reliable, the reaction is mild, and the apparatus is small and portable and is convenientto control. The invention provides the possibility of preparing and using NO for people with chronic illness for long time in home. The portable NO production machine is better in safety and lower incost when compared with clinical NO gas cylinders and blending apparatuses that are applied clinically internationally.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a portable nitric oxide manufacturing machine. Background technique [0002] Nitric oxide is an endogenous small molecule substance with important physiological functions. The main functions include: increasing vasodilation, preventing platelet adhesion, promoting wound healing and angiogenesis, and can be released by macrophages and nasal epithelial cells as an effective antibacterial agent. Direct inhalation of nitric oxide therapy is approved by the US Food and Drug Administration as a treatment for neonatal persistent pulmonary hypertension, and has been proven to improve the body's oxidation capacity and reduce high-risk extracorporeal cardiopulmonary support for critical illness. Nitric oxide inhalation therapy can not only dilate blood vessels in the lungs, reduce pulmonary vascular resistance, but also help in the treatment of other diseases including...

Claims

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Application Information

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IPC IPC(8): C25B1/00C01B21/24
CPCC25B1/00C01B21/24
Inventor 陈涛郭旭周俊宇秦玉
Owner 南京诺令生物科技有限公司
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