Novel method of improving tumor hypoxia

A tumor and drug technology, applied in the field of biomedicine, can solve the problems of time and money cost, aggravate the shortage of blood resources, etc., achieve the effect of improving delivery efficiency, improving tumor hypoxic microenvironment, and simple nutritional requirements

Inactive Publication Date: 2020-03-20
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

However, the development of artificial oxygen carriers is due to the need for pathogen detection once the blood donated by humans is collected, specific refrigerated storage c...

Method used

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  • Novel method of improving tumor hypoxia
  • Novel method of improving tumor hypoxia

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Experimental program
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Embodiment

[0028] Prepare for the experiment: Prepare a 500ml Erlenmeyer flask, pour cyanobacteria and sterilized BG11 medium into the aseptic operating table, seal the bottle mouth with a breathable parafilm, and place it in the sun for cultivation and amplification.

[0029] Experiment 1: Infinite Oxygen Production by Cyanobacteria in Vitro

[0030] Prepare a colorless transparent glass vial with a density of 2×10 8 Add 2 mL of ethyl acetate to 8 mL of cfu / mL bacterial solution, and monitor the oxygen generation with a dissolved oxygen meter under 660nm laser or no laser irradiation;

[0031] The unlimited oxygen production capacity of cyanobacteria was measured by a dissolved oxygen meter, see figure 1 , has been given 660nm laser irradiation, the oxygen release value has been increasing, when there is no laser irradiation, the oxygen release value quickly dropped to zero.

[0032] Experiment 2: The effect of cyanobacteria on improving hypoxia in vivo

[0033] Take the density as 1...

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Abstract

The invention provides a cyanobacterium of a living drug. Oxygen is generated by means of photosynthesis under laser radiation to improve tumor hypoxia, so that the tumor microenvironment is changed,an oxygen-increasing tumor therapeutic effect is achieved, and novel selection is provided for cancer treatment. An in vitro experiment verifies that the cyanobacterium can generate oxygen infinitelyunder a condition of 660 nm laser radiation. An in vivo experiment verifies that the tumor hypoxia condition is improved obviously by tail vein injection of the cyanobacterium into a mouse body and radiation on mouse tumors by 660 nm laser.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a new method for improving tumor hypoxia. Background technique [0002] Traditional methods of tumor treatment mainly include surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy, etc. These methods can effectively treat some tumors and control tumor metastasis, but there are still some defects, such as high recurrence rate of surgical resection, chemotherapy easily induces systemic Sexual adverse reactions, serious damage to normal tissue around the tumor by ionizing radiation, etc. Tumor phototherapy is a new cancer treatment method with good specificity and non-invasiveness that has been extensively studied in recent years. It is mainly divided into photothermal therapy and photodynamic therapy. Oxygen is the key raw material for the efficacy of photodynamic therapy. Under laser irradiation, it can be activated by photosensitive drugs into sing...

Claims

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Application Information

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IPC IPC(8): A61K35/748A61K41/00A61P35/00A61P35/02
CPCA61K35/748A61K41/0052A61K41/0057A61P35/00A61P35/02A61K2300/00
Inventor 蔡林涛何华美刘兰兰梁锐晶周海梅潘宏
Owner SHENZHEN INST OF ADVANCED TECH
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