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Metronidazole tablet and preparation method thereof

A technology of metronidazole tablets and metronidazole, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory dissolution effects and poor drug efficacy, To achieve the effect of improving dissolution effect, improving quality and curative effect, and good dissolution rate

Active Publication Date: 2020-03-27
北京鑫开元医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, to provide a metronidazole tablet and a preparation method thereof, aiming to solve the technical problem that the dissolution effect of the existing metronidazole tablet is not ideal, resulting in poor drug efficacy

Method used

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  • Metronidazole tablet and preparation method thereof
  • Metronidazole tablet and preparation method thereof
  • Metronidazole tablet and preparation method thereof

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preparation example Construction

[0060]The second aspect of the embodiments of the present invention provides a method for preparing metronidazole tablets, comprising the following steps: Step S10: pulverize the metronidazole raw material and pass through a first mesh sieve to obtain metronidazole, the metronidazole The particle size of nidazole is not greater than 300 microns.

[0061] The mesh number of the first mesh sieve can be set as required, for example, it can be 60 mesh sieves. After pulverizing the metronidazole raw material, the particle size of the metronidazole raw material can be screened through the first mesh sieve, so that the particle size of the obtained metronidazole is not greater than 300 microns. On the one hand, when the particle size of the raw material powder is too fine, the material will aggregate and affect the disintegration of the product, thereby affecting the dissolution; on the other hand, when the particle size of the raw material powder is too large, the effect of forming ...

Embodiment 1

[0089] Metronidazole is not pulverized and sieved, the D90 is about 300 microns, and the D90 of calcium hydrogen phosphate is about 200 microns.

[0090] Taking the total mass of the metronidazole tablet as 100%, the composition of the mass percentage that the metronidazole tablet includes is:

[0091]

[0092] Metronidazole tablet preparation method is as follows:

[0093] Step S601: Take the metronidazole raw material for later use.

[0094] Step S602: Weigh the metronidazole, filler and disintegrant according to the preset mass percentage, mix them uniformly in a wet granulator, add the binder for less than 5 minutes to granulate, and pass through a 20-mesh sieve to obtain wet granules , wherein the particle size of the filler is 200 microns.

[0095] Step S603: drying the wet granules, the drying temperature is not higher than 60° C., and the moisture content of the dried granules is 2.5%.

[0096] Step S604: After the wet granules are dried, the granules are sized, ...

Embodiment 2

[0101] Metronidazole is not pulverized and sieved, the D90 is about 250 microns, and the D90 of calcium hydrogen phosphate is about 120 microns.

[0102] Taking the total mass of the metronidazole tablet as 100%, the composition of the mass percentage that the metronidazole tablet includes is:

[0103]

[0104] Metronidazole tablet preparation method is as follows:

[0105] Step S701: Pulverize the metronidazole raw material, pass through a 60-mesh sieve, and set aside.

[0106] Step S702: Weigh the metronidazole, filler and disintegrant according to the preset mass percentage, mix them uniformly in a wet granulator, add the binder for less than 5 minutes to granulate, and pass through a 20-mesh sieve to obtain wet granules , wherein the particle size of the filler is 200 microns.

[0107] Step S703: drying the wet granules, the drying temperature is not higher than 60° C., and the moisture content of the dried granules is 2.6%.

[0108] Step S704: After the wet granules...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a metronidazole tablet and a preparation method thereof. The preparation method comprises the following steps of:smashing metronidazole raw materials, and screening through a first-mesh sieve to obtain metronidazole, wherein the particle size of the metronidazole is not greater than 300 micrometers; according to preset parts by weight, weighing the metronidazole, a filler and disintegrant, evenly mixing the metronidazole, the filler and the disintegrant in a wet granulator, adding an adhesive for granulation, and screening the mixture by a second-mesh sieve to obtain wet particles, wherein the particle size of the filler is not greater than 150 micrometers; after the wet particles are dried, carrying out particle arrangement, adding a lubricating agent, and mixing in a mixer to obtain an intermediate particle; and carrying out tableting, coating and packaging on the intermediate particle to obtain the metronidazole tablet. The preparation method, which is provided by the embodiment of the invention, for the metronidazole tablet has a stable technology, the product quality of the metronidazole tablet which is finally obtained is guaranteed, the metronidazole table exhibits a better dissolution rate, the dissolution effect of the metronidazole tablet is effectively improved, and the quality and the curative effect of the metronidazole tablet are improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a metronidazole tablet and a preparation method thereof. Background technique [0002] Metronidazole is a synthetic oral antiprotozoal and antibacterial drug, which may exert antibacterial activity in an anaerobic environment through the following mechanism: After the drug enters the body, it is affected by the intracellular ion transporter, forming a mechanism that promotes the transport of the drug into the cell. concentration gradient. The drug forms free radicals inside the cell, which in turn interact with intracellular components, ultimately leading to the death of the microorganism. Metronidazole has a wide range of uses and has obvious curative effects on a variety of bacterial diseases: [0003] (1) Treatment Treatment of intestinal and parenteral amoebiasis, such as peptic ulcer. Metronidazole is effective in treating peptic ulcer, can improve gastric m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4164A61K47/36A61P33/02A61P31/04A61P1/04A61P11/00A61P3/06A61P1/02A61P7/04A61P15/00A61P15/02A61P17/00
CPCA61K9/28A61K9/2059A61K31/4164A61P33/02A61P31/04A61P1/04A61P11/00A61P3/06A61P1/02A61P7/04A61P15/00A61P15/02A61P17/00
Inventor 霍志强赵婷陈华王传旭霍燕武雪戴信敏
Owner 北京鑫开元医药科技有限公司
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