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Preparation and application of a black tin dioxide nano-photothermal material

A technology of tin dioxide and nano-light, applied in the direction of tin oxide, wave energy or particle radiation treatment materials, medical preparations of non-active ingredients, etc., can solve problems such as poor penetration depth, and achieve easy operation and easy access to raw materials , good biocompatibility

Active Publication Date: 2021-08-10
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tin dioxide is usually excited by ultraviolet light, and its poor tissue penetration depth has become the Achilles' heel in the treatment of deep tumors

Method used

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  • Preparation and application of a black tin dioxide nano-photothermal material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Black nano nano-optic thermal material, including the following steps:

[0028] (1) Weigh 1 g of nano nano particles SNO 2 After the sodium borohydride solid, after sufficiently polishing, the two are mixed uniform, transferred to the muffle furnace for calcination, in the Ar gas environment, the calcination temperature is 400 ° C, and the high temperature reaction is 3 hours;

[0029] (2) After calcination, it was washed 3 times with water and ethanol, and centrifuge was carried out with centrifuge, the centrifuge speed was 8000 r / min, the centrifugal time was 5 min, and the unreacted borohydride was removed to obtain a black tin oxide SNO. 2-x solid;

[0030] (3) Decoixi Sno obtained in obtained 2-x In addition, 50% ethanol solution was added, then ammonia water was adjusted to pH = 9, and 20 microliters of silica coupling agent KH550 (APTES) reacted under stirring, the black tin oxide dispersion wrapped in amino silica was obtained;

[0031] (4) Preparation of the acti...

Embodiment 2

[0035] Black nano nano-optic thermal material, including the following steps:

[0036] (1) Weigh 1 g of nano nano particles SNO 2 After the sodium borohydride solid, after sufficiently polishing, the two are mixed uniform, transferred to the muffle furnace for calcination, in the Ar gas environment, the calcination temperature is 450 ° C, and the high temperature reaction is 2 hours;

[0037] (2) After calcination, it was washed 3 times with water and ethanol, and centrifuge was carried out with centrifuge, the centrifuge speed was 8000 r / min, the centrifugal time was 5 min, and the unreacted borohydride was removed to obtain a black tin oxide SNO. 2-x solid;

[0038] (3) Decoixi Sno obtained in obtained 2-x In solid, 50% ethanol solution was added, then an ammonia water was adjusted to pH = 9, and 20 microliters of silane coupling kH550 (APTES) reacted under stirring, gave a black tin oxide dispersion of amino silica wrapped. ;

[0039] (4) Preparation of the activated hyaluron...

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Abstract

The invention discloses the preparation and application of a black tin dioxide nano-photothermal material. During the preparation, tin dioxide and hyaluronic acid are used as raw materials, a high-temperature reduction method is adopted, a silane coupling agent is added for reaction, and finally hyaluronic acid is passed through HA modified to obtain the final product black tin dioxide nano-photothermal material. Experiments have proved that the nanomaterial can not only respond to hydrogen peroxide (H 2 o 2 ) to generate reactive oxygen species, and after 808 nm laser irradiation, nanomaterials can generate a large amount of reactive oxygen species and emit heat in tumor cells, which can be used as drugs for photothermal and photodynamic therapy of tumors, and realize near-infrared light-induced photothermal PTT photodynamic PDT synergistic therapy. The black tin dioxide nano photothermal material prepared by the invention provides a new application for the application of tin in biomedicine.

Description

Technical field [0001] The present invention relates to the preparation of a nano material having a good biocompatible nano-photothermal material and its application. Background technique [0002] In recent years, inherent physiological micro environments in which tumor tissue, such as lower pH, laboremic environment, excess hydrogen peroxide, oxidative resentment, etc. have become targets for people to design tumor identification drugs. In view of the characteristics of the tumor microenvironment, advanced nanomaterials have been introduced to form hydroxy free radicals (• OH), mainly for tumor chemical kinetics (CDT) by Fenton and class FENTON. CDT therapy not only has high logic and selectivity, but can be excited by endogenous stimulation. The hydrogen peroxide content in the tumor is insufficient to form a sufficient amount of (• OH) to kill tumor cells, so developing nanocomposite drugs with multi-functional nanocomposites is used for tumor treatment into our pursuit goals....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/61A61P35/00C01G19/02
CPCA61K41/0052A61K41/0057A61K47/61A61P35/00C01G19/02A61K2300/00
Inventor 沈星灿郭文伟丁兆扬李金灵
Owner GUANGXI NORMAL UNIV