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Ci-hang tablets and preparation method thereof

A technology of aerial film and angelica, applied in the field of medicine, can solve the problems of content loss, patients prone to aversion and resistance, poor oral compliance, etc. Effect

Inactive Publication Date: 2020-04-03
JIANGXI JIUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] In addition, due to the poor action of starch in the prior art, the production process is prone to cracks and fragments, and the disintegration time is long
At the same time, the content of the drug is not guaranteed, and the one-time dosage is large, resulting in poor patient compliance and seriously affecting the sales of the product. It is imminent to solve the above problems of the product
[0023] In the prior art, since the adjuvant starch plays multiple roles in the tablet as filler, binder and disintegrating agent, its effect on the disintegration time limit of the finished product inspection item is poor, and the disintegration time limit of the drug is long. Affect the dissolution of the drug in the body, and the drug effect is slow
[0024] The current technical research shows that the main components of Rhizoma Chuanxiong and Angelica are ferulic acid, and motherwort also contains a component that is very familiar with ferulic acid, and it is impossible to judge whether it is ferulic acid or to separate it according to the current technology. Therefore, the current content detection of Cihang Tablets contains this unknown ingredient and calculates the content as ferulic acid
Its ferulic acid is a component that is easily affected by temperature. In the production and extraction process of Cihang Tablets, the conventional heating extraction and concentration method is adopted. The content of the medicinal materials is seriously lost during the extraction and concentration process, resulting in generally low content in the finished product. It is taken at one time. The dosage is large, the oral compliance is poor, and patients are prone to disgust and resistance

Method used

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  • Ci-hang tablets and preparation method thereof
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Examples

Experimental program
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Effect test

Embodiment

[0076] Embodiment: Anyone who is diagnosed with amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, postpartum haemorrhage, and endless lochia will take Cihang Tablets of the present invention for treatment, 2 tablets at a time, 2 times a day, every 7 days as a course of treatment , after a course of treatment, the curative effect was counted.

Embodiment 1

[0089] Recipe: Motherwort 300g Angelica 200g Chuanxiong 150g

[0090] Excipients: compressible starch 20g sodium carboxymethyl starch 10g

[0091] Preparation method: crush Ligusticum chuanxiong into fine powder, pass through a 100-mesh sieve, and set aside; Chinese angelica is broken as appropriate, and 80% ethanol is used as a solvent to collect 6 times the percolation liquid of the medicinal material, and the ethanol is recovered in a vacuum double-effect concentrated ointment collection tank , concentrated at low temperature to a clear paste with a relative density of 1.22-1.25 (60°C); put the dregs and Motherwort in the countercurrent extraction unit of the external circulation tank group, add 8 times the amount of water to decoct twice, each time for 2 hours, and decoct liquid, filtered, and the filtrate was concentrated at low temperature in a vacuum double-effect concentrated ointment collection tank to a clear paste with a relative density of 1.22-1.25 (60°C); add the...

Embodiment 2

[0093] Recipe: Motherwort 300g Angelica 200g Chuanxiong 150g

[0094] Excipients: compressible starch 20g, sodium carboxymethyl starch 15g

[0095] Preparation method: crush Ligusticum chuanxiong into fine powder, pass through a 100-mesh sieve, and set aside; Chinese angelica is broken as appropriate, and 80% ethanol is used as a solvent to collect 6 times the percolation liquid of the medicinal material, and the ethanol is recovered in a vacuum double-effect concentrated ointment collection tank , concentrated at low temperature to a clear paste with a relative density of 1.22-1.25 (60°C); put the dregs and Motherwort in the countercurrent extraction unit of the external circulation tank group, add 8 times the amount of water to decoct twice, each time for 2 hours, and decoct liquid, filtered, and the filtrate was concentrated at low temperature in a vacuum double-effect concentrated ointment collection tank to a clear paste with a relative density of 1.22-1.25 (60°C); add th...

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Abstract

The invention belongs to the technical field of medicines, and relates to Ci-hang tablets and a preparation method thereof. The Ci-hang tablets are prepared from traditional Chinese medicines with thefunctions of removing blood stasis, relieving pain, activating the circulation of the blood and regulating menstruation, including motherwort herb and ligusticum chuanxiong, in coordination with Chinese angelica roots with the functions of tonifying the blood, regulating the uterus and enhancing body resistance, so that the medicines synergistically take an effect so as to achieve significant curative effects in the aspects of treating women's dysmenorrhea, lumps in the abdomen, postpartum anemia fainting and persistent lochia. The Ci-hang tablets disclosed by the invention are prepared fromthe following raw materials and auxiliary materials: 300 g of motherwort herb, 200 g of Chinese angelica roots, 150 g of ligusticum chuanxiong, 10-40 g of pressure-dutable starch, and 10-60 g of carboxymethyl starch sodium.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a Cihang tablet and a preparation method thereof. Background technique [0002] Irregular menstrual bleeding is a common disease in gynecology, manifested as abnormal menstrual cycle or bleeding volume. Menstrual cycle or bleeding disorder, may be accompanied by abdominal pain before and during menstruation. There are many reasons for menstrual disorders. Local inflammation of reproductive organs, such as vaginitis, pelvic inflammatory disease, cervicitis and other gynecological diseases can cause menstrual disorders. Irregular menstruation will not only cause gynecological inflammation, affect the work and life of patients, but also lead to infertility in severe cases. [0003] Cihang tablets, the main ingredients: Motherwort, Angelica, Chuanxiong. Cihang Tablet is a gynecological prescription drug. Dispelling blood stasis to generate new energy. It is used for irregular men...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/20A61K9/28A61K47/36A61P15/00
CPCA61K9/2059A61K9/28A61K36/232A61K36/236A61K36/533A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P15/00A61K2300/00
Inventor 谢明艳陈邦辉孙新平刘建春杨华许焰辉
Owner JIANGXI JIUHUA PHARMA
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