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High-brightness stable perovskite magneto-optical microsphere for CTC capture

A technology of perovskite and microspheres, which is applied in nanotechnology, nano-optics, and luminescent materials for materials and surface science, can solve the problems of fluorescent substances flickering, quenching fluorescence efficiency, and low efficiency, achieving low cost, The effect of simple preparation process and short time consumption

Active Publication Date: 2020-05-05
JILIN NORMAL UNIV
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Problems solved by technology

[0003] Aiming at the problems of flickering, quenching and low fluorescence efficiency of most of the fluorescent substances currently used in the capture of CTCs by magneto-optic microspheres, the purpose of the present invention is to provide a bright and stable perovskite magnetic material for CTC capture. Optical microspheres, the structure of the composite material of the magneto-optic microspheres with high fluorescence emission and magnetic targeting functions is (MAPbBr 3 / Fe 3 o 4 )@MPSs@SiO 2 , can be used for CTCs detection and capture

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  • High-brightness stable perovskite magneto-optical microsphere for CTC capture

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[0020] A high-brightness and stable perovskite magneto-optic microsphere for CTC capture, the structural formula of the perovskite magneto-optic microsphere is (MAPbBr 3 / Fe 3 o 4 )@MPSs@SiO 2 , the specific steps of its preparation method are as follows:

[0021] 1), Fe 3 o 4 Preparation of @PEG magnetic nanoparticles: FeCl 3 ·6H 2 O (2.7022g), FeCl 2 4H 2 O (1.1929g) and PEG-4000 (10g) were dissolved in 150mL deionized water, and stirred at room temperature for ten minutes to obtain a mixed solution; the mixed solution was transferred to a 500mL three-necked flask, and 100mL of ammonia water was added to the mixed solution (25%), allowing it to be mechanically stirred at 90°C in a constant temperature water bath for 3h to obtain a black uniform suspension; when the three-necked flask was naturally cooled to room temperature, the precipitate was separated and collected by a magnet, and washed with deionized water and ethanol. Dry at 50°C for 12h to obtain Fe 3 o 4 @P...

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Abstract

The invention discloses a high-brightness stable perovskite magneto-optical microsphere for CTC capture. The preparation method comprises the following steps: by taking polystyrene porous spheres as shells, uniformly encapsulating Fe3O4 magnetic particles and MAPbBr3 quantum dots in the shells by utilizing a self-assembly method, and coating SiO2 shell layers on the surfaces of the shells to successfully construct (MAPbBr3 / Fe3O4)-coated MPSs-coated SiO2 magneto-optical microspheres; through surface modification, connecting a biological specific antibody SA and anti-EpCAM, and specifically capturing and identifying circulating tumor cells (CTCs), wherein perovskite quantum dots selected by the magneto-optical microspheres have high green fluorescence emission and high fluorescence quantum yield; and packaging the porous polystyrene microspheres and coating a silicon shell layer with the porous polystyrene microspheres. Compared with the prior art, the fluorescence stability of the magneto-optical microspheres is remarkably improved, direct contact between the MAPbBr3 quantum dot and a monitoring target object is avoided, the toxicity problem of heavy metal Pb in the biological monitoring process is solved, safety and no toxicity are achieved, and application in biomedicine is well developed. The preparation method disclosed by the invention has the advantages of mild reaction conditions, simple preparation process, short consumed time and relatively low cost.

Description

technical field [0001] The invention belongs to the technical field of micro-nano functional materials, and in particular relates to a perovskite magneto-optical microsphere (MAPbBr) with high fluorescence emission and good magnetic properties. 3 / Fe 3 o 4 )@MPSs@SiO 2 . Background technique [0002] Cancer is one of the most serious diseases threatening human health, and tumor metastasis is the main reason for the high mortality rate of cancer. The detection of CTCs can be used to explain tumor metastasis behavior and reflect tumor invasiveness, which is of great significance for the judgment of cancer treatment effect and tumor prediction. However, there are only a few to hundreds of CTCs per mL of blood, while the number of blood cells exceeds 10 9 One, this requires that the detection method we use can efficiently and accurately detect very few target cells; therefore, it is urgent to develop a highly sensitive and specific detection method. Today's capture methods...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C09K11/02B82Y30/00B82Y20/00B82Y25/00
CPCC09K11/06C09K11/02B82Y30/00B82Y20/00B82Y25/00C09K2211/10
Inventor 杨丽丽马小钧王奉友范琳刘晓艳
Owner JILIN NORMAL UNIV
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