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Ulcer paste and preparation method thereof

A technology based on ulcers, which is applied in the field of medicine, can solve the problems of difficulty in continuous action, short action time, and easy to fall off, and achieve the effect of improving comfort, improving adhesion, and not easy to fall off

Active Publication Date: 2020-05-08
LIUZHOU WORKERS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention overcomes the technical problems in the prior art that antibiotics cannot be applied to all ulcers, the composition of the gargle is single, and the action time is short. For patients with oral ulcers after chemotherapy and hematopoietic stem cell transplantation, a kind of ulcer paste with anti-inflammation, analgesia, promotion of wound healing, strong adhesion, safe and effective was developed

Method used

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  • Ulcer paste and preparation method thereof
  • Ulcer paste and preparation method thereof
  • Ulcer paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An ulcer paste, which consists of the following components: 5 million units of nystatin, 3ml of lidocaine, 8g of montmorillonite powder, 5ml of sodium chloride injection with a mass concentration of 0.9%, recombinant human granulocyte stimulating factor 25ug of injection, 5ml of Kangfuxin solution, 0.8g of metronidazole tablet, 1g of chitosan, 0.1ml of acetic acid, and 10g of pectin, wherein the pectin has a molecular weight of 50000Da and a degree of esterification of 68%. Described chitosan is oligomeric chitosan, and the molecular weight of described oligomeric chitosan is 400;

[0029] And hydrogen peroxide, the mass concentration of the hydrogen peroxide is 1% of the total mass of the montmorillonite, lidocaine, nystatin, metronidazole tablets, Kangfuxin solution, chitosan and acetic acid;

[0030] And calcium chloride solution, the molar concentration of described calcium chloride solution is 8mol / L, described calcium chloride solution and described montmorillonit...

Embodiment 2

[0038] An ulcer paste, which is composed of the following components: 1 million units of nystatin, 10 ml of lidocaine, 3 g of montmorillonite powder, 10 ml of sodium chloride injection with a mass concentration of 0.9%, recombinant human granulocyte stimulating factor Injection 10ug, Kangfuxin solution 10ml, metronidazole tablet 1.2g, chitosan 0.1g, acetic acid 2ml, pectin 0.2g, wherein, the molecular weight of the pectin is 60000Da, and the degree of esterification is 70%. The chitosan is oligomeric chitosan, and the molecular weight of the oligomeric chitosan is between 6000;

[0039] And hydrogen peroxide, the mass concentration of the hydrogen peroxide is 0.1% of the total mass of the montmorillonite, lidocaine, nystatin, metronidazole tablets, Kangfuxin solution, chitosan and acetic acid;

[0040]And calcium chloride solution, the molar concentration of described calcium chloride solution is not less than 8mol / L, described calcium chloride solution and described montmoril...

Embodiment 3

[0048] An ulcer paste, which consists of the following components: 3 million units of nystatin, 5 ml of lidocaine, 6 g of montmorillonite powder, 8 ml of sodium chloride injection with a mass concentration of 0.9%, recombinant human granulocyte stimulating factor Injection 15ug, Kangfuxin solution 8ml, metronidazole tablet 1.0g, chitosan 0.5g, acetic acid 1ml, pectin 5g, wherein the pectin has a molecular weight of 70000Da and a degree of esterification of 69%. Described chitosan is oligomeric chitosan, and the molecular weight of described oligomeric chitosan is between 5000;

[0049] And hydrogen peroxide, the mass concentration of the hydrogen peroxide is 0.5% of the total mass of the montmorillonite, lidocaine, nystatin, metronidazole tablets, Kangfuxin solution, chitosan and acetic acid;

[0050] And calcium chloride solution, the molar concentration of described calcium chloride solution is not less than 8mol / L, described calcium chloride solution and described montmoril...

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Abstract

The invention discloses an ulcer paste. The ulcer paste is composed of the following components: 1-5 million units of nystatin, 3-10 ml of lidocaine, 3-8 g of montmorillonite powder, 2-10 ml of a sodium chloride injection with a mass concentration of 0.9%, 10-25 [mu]g of a recombinant human granulocyte colony-stimulating factor injection, 5-10 ml of a Kangfuxin solution, 0.8-1.2 g of metronidazoletablets, 0.1-1 g of chitosan, 0.1-2 ml of acetic acid, and 0.2-10 g of pectin. The preparation method comprises the steps of performing primary wrapping by using the chitosan, and performing secondary wrapping by using the pectin. The prepared ulcer paste has strong adhesion and no odor, and multiple ingredients in the formula cooperate with one another, so that the ulcer paste has anti-inflammatory, analgesic, wound healing promoting, strong-adhesion, safe and effective therapeutic effects on patients with oral ulcers after chemotherapy and hematopoietic stem cell transplantation.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ulcer paste and a preparation method thereof. Background technique [0002] Cancer patients, especially those with hematologic malignancies after chemotherapy and hematopoietic stem cell transplantation, often suffer from oral ulcers. The pain is unbearable, affecting eating, prolonging the recovery time of the disease, and in severe cases, sepsis can be life-threatening. At present, the treatment of oral ulcers in this type of patients includes systemic application of antibiotics, gargle with gargle and local spraying of ulcer powder for external use. Systemic antibiotics are effective in ulcers with infection but not in non-infected patients. Various gargles have single ingredients and short action time. However, the topical Ulcer powder has low adhesion, and it is easy to fall off under the action of saliva, so it is difficult to continue to produce effects. [0003] Mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/06A61K47/36A61P1/02A61P29/00A61K31/167A61K31/4164A61K31/7048A61K33/06A61K35/64
CPCA61K38/19A61K33/06A61K31/7048A61K31/167A61K35/64A61K31/4164A61K9/06A61K9/006A61K47/36A61P1/02A61P29/00A61K2300/00Y02A50/30
Inventor 覃春捷罗斌聂伟业彭梅刘畅陈宏阳洁潘惠安蒙艺方梁庆秋
Owner LIUZHOU WORKERS HOSPITAL
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