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Stretch mark repair preparation containing stem cell exosome as well as preparation method and application of preparation

A technology of exosomes and stretch marks, which is applied in the field of cell bioengineering technology and medical beauty, can solve the problems of skin irritation and poor repair effect, and achieve the effects of reducing stretch marks, promoting proliferation and restoring elasticity

Inactive Publication Date: 2020-05-22
西安九州再生医学集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, traditional preparations such as pregnancy creams used to repair stretch marks are irritating to the skin and have poor repair effects.

Method used

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  • Stretch mark repair preparation containing stem cell exosome as well as preparation method and application of preparation
  • Stretch mark repair preparation containing stem cell exosome as well as preparation method and application of preparation
  • Stretch mark repair preparation containing stem cell exosome as well as preparation method and application of preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] This embodiment provides a method for preparing exosomes from umbilical cord mesenchymal stem cells, which includes the following steps:

[0041] (1) Collect the umbilical cord tissue of full-term healthy infants, store it in a sterile bottle filled with phosphate buffered saline solution (containing 100 U / mL of penicillin and streptomycin), and store it for later use (it needs to be processed within 4 hours); The veins and arteries of the umbilical cord tissue were stripped of Wharton's jelly and cut into 2mm 3 Then place it in a culture bottle and spread it evenly, and add a small amount of complete medium to keep it moist. The medium can use the existing DMEM / F12 medium (containing 15% fetal bovine serum), and add enough medium after 24 hours After that, the medium was changed every 3 days, and the cells were grown to confluence and then passaged. After passage, the culture medium was cultured with DMEM / F12 medium (containing 10% fetal bovine serum); when the 3rd to ...

Embodiment 2

[0045] as attached figure 1 As shown, this embodiment provides a preparation for repairing stretch marks containing stem cell exosomes and a preparation method thereof. Specifically, the preparation method for repairing preparations for stretch marks includes the following steps:

[0046] (1) Weigh 0.0005 g of umbilical cord mesenchymal stem cell exosomes, 2 g of 1,3-propanediol, 0.1 g of tremella polysaccharide, 0.03 g of disodium edetate, 2 g of soybean glyceride, and unsaponifiable matter of shea butter 1.5g, hydrogenated jojoba oil 4g, hydrogenated sweet almond oil 1.5g, hydrogenated olive oil 2g, tocopheryl acetate 0.2g, hydrogenated lecithin 3.5g, ceramide 1 0.5g, allantoin 0.05g, myrrh Alcohol 0.05g, palmitoyl tripeptide-1 2g, palmitoyl tetrapeptide-7 2g, leuconostococcus / radish root fermentation product filtrate 1g, water 77.5695g, set aside. figure 1 Among them, group A materials include water, 1,3-propanediol, ceramide, allantoin, tremella polysaccharide, disodium e...

Embodiment 3

[0053] This embodiment provides a preparation for repairing stretch marks containing stem cell exosomes and a preparation method thereof. Specifically, the preparation method for repairing stretch marks includes the following steps:

[0054] (1) Weigh 0.005g of umbilical cord mesenchymal stem cell exosomes, 4g of 1,3-propanediol, 0.3g of tremella polysaccharide, 0.05g of disodium edetate, 3g of soybean glyceride, and unsaponifiable matter of shea butter 4g, hydrogenated jojoba oil 6g, hydrogenated sweet almond oil 4g, hydrogenated olive oil 5g, tocopheryl acetate 0.6g, hydrogenated lecithin 4.5g, ceramide 1 1.5g, allantoin 0.3g, bisabolol 0.15 g, palmitoyl tripeptide-1 5g, palmitoyl tetrapeptide-7 5g, leuconostococcus / radish root fermentation product filtrate 2.5g, water 54.095g, set aside.

[0055] (2) Disperse tremella polysaccharide in 1,3-propylene glycol, add water, disodium edetate, ceramide 1 and allantoin and heat to 75-80°C for stirring and mixing to obtain mixture A,...

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Abstract

The invention discloses a stretch mark repair preparation containing a stem cell exosome as well as a preparation method and application of the preparation, and belongs to the fields of cell bioengineering technology and cosmetic medicine. The stretch mark repair preparation includes the following components: the umbilical cord mesenchymal stem cell exosome, a wetting agent, a thickener, a chelating agent, an emollient, an emulsifier, a skin conditioner and a solvent. The stretch mark repair preparation obtained by adding the umbilical cord mesenchymal stem cell exosome according to the embodiments of the invention is safe and effective, and has significant effects in repairing and fading stretch marks, making abdominal skin delicate, improving skin firmness and moisture.

Description

technical field [0001] The invention relates to the field of cell bioengineering technology and medical aesthetics, in particular to a preparation for repairing stretch marks containing stem cell exosomes, a preparation method and application thereof. Background technique [0002] Mesenchymal stem cells play an important role in regenerative medicine, have self-renewal and multi-directional differentiation potential, and have chemotaxis, can migrate to injury and inflammation sites, and repair local tissues. Human umbilical cord is an important source of mesenchymal stem cells. Compared with stem cells from other sources, human umbilical cord mesenchymal stem cells have the advantages of low immunogenicity, non-invasive harvest, easy in vitro expansion, and few ethical issues. They have good potential in cell therapy. application prospects. [0003] Exosomes are cell-derived nanoscale extracellular vesicles that are released into the surrounding body fluid after the fusion ...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/34A61K8/73A61K8/86A61K8/31A61K8/92A61K8/55A61K8/9789A61K8/67A61K8/68A61K8/49A61K8/64A61Q17/00A61Q19/00A61Q19/08
CPCA61K8/31A61K8/34A61K8/345A61K8/4946A61K8/553A61K8/64A61K8/678A61K8/68A61K8/73A61K8/86A61K8/922A61K8/9789A61K8/99A61Q17/005A61Q19/00A61Q19/08
Inventor 田丽军戴博刘莹李敏刘炜琳何婷婷聂苏秦
Owner 西安九州再生医学集团有限公司
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