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A kind of ophthalmic compound preparation and preparation method thereof

A compound preparation and ophthalmic technology, which can be used in medical preparations without active ingredients, medical preparations containing active ingredients, and drug combinations, etc., and can solve the problems of poor adhesion, poor stability, and short storage time of active ingredients.

Active Publication Date: 2021-03-16
AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to overcome the defects of poor stability, short storage time and poor adhesion of active components of traditional eye washing solutions, the present invention provides an ophthalmic compound preparation and a preparation method thereof for alleviating and / or improving visual fatigue and dry eye syndrome

Method used

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  • A kind of ophthalmic compound preparation and preparation method thereof
  • A kind of ophthalmic compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Preparation of Carboxylated β-Cyclodextrin Crosslinked by Chondroitin Sulfate

[0075] 1) Dissolve 10mmol of monocarboxylated β-cyclodextrin (each molecule of cyclodextrin contains a single carboxylation group unit) and 12mmol of N-hydroxysuccinimide in 50mL of distilled water, add 12mmol of EDC, ice bath conditions Stir and react for 2 hours; then slowly add an aqueous solution of chondroitin sulfate with amino units (the content of chondroitin sulfate is 18 mmol), stir slowly for 1 hour in an ice bath, then raise the temperature to 35°C in a water bath, keep warm and slowly stir for 12 hours;

[0076] 2) After the reaction is completed, the reaction solution is concentrated, and the concentrated solution is dialyzed twice in a dialysis bag for 16 hours to remove unreacted small molecule raw materials, and then purified by silica gel column chromatography to obtain chondroitin sulfate-modified carboxylated β-ring Dextrin; the purification parameters are: silica gel col...

Embodiment 2

[0080] Preparation of Ophthalmic Compound Preparation 1

[0081] (1) Preparation of component A

[0082] S1-1: Weigh 3g of sodium hyaluronate and 2g of trehalose into 65ml of distilled water, stir and swell in a water bath at 80°C for 30min, fully dissolve and lower the temperature to room temperature; add 0.6g of betaine while stirring, and keep stirring until dissolved, then add 1g of alanylglutamine, continue to stir and dissolve, then add distilled water until the total weight of the solution is 100g, as the base solution;

[0083] S1-2: Immerse 10 g of the chondroitin sulfate cross-linked modified cyclodextrin prepared above into the above base solution, heat it in a water bath to 45 °C, stir slowly for 30 min, and then treat it under 100 W ultrasonic for 3 min; stand at 4 °C for 6 h Afterwards, it was frozen at -80°C for 6 hours, and about 17 g of solid component A was obtained by vacuum freeze-drying.

[0084] After the obtained solid was sterilized by ultraviolet rad...

Embodiment 3

[0090] Preparation of ophthalmic compound preparation 2

[0091] (1) Preparation of component A

[0092]S1-1: Weigh 2g of sodium hyaluronate and 1.5g of trehalose into 60ml of distilled water, stir and swell in a water bath at 80°C for 30 minutes, and after fully dissolving, lower the temperature to room temperature; add 0.5g of betaine while stirring, and continuously Stir until dissolved, then add 1.2g of alanyl glutamine, continue to stir and dissolve, then add distilled water until the total weight of the solution is 100g, as the base liquid;

[0093] S1-2: Immerse 8 g of the cyclodextrin cross-linked and modified by chondroitin sulfate above into the above base solution, heat it in a water bath to 45°C, stir slowly for 30 minutes, and then treat it under 150W ultrasonic for 3 minutes; Freeze at -80°C for 6 hours, and obtain solid component A by vacuum freeze-drying.

[0094] After the obtained solid was sterilized by ultraviolet radiation, it was divided into sterilized...

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Abstract

The invention discloses a compounded ophthalmic preparation which comprises a solid component A and a component B, wherein the component B is used as a buffer isotonic solution; the component A comprises a chondroitin sulfate cross-linking modified carboxylated beta-cyclodextrin carrier as well as components, namely sodium hyaluronate, trehalose, glycine betaine and alanyl glutamine matrix which are carried by the carrier; and the component B as the buffer isotonic solution comprises povidone, taurine, glycerinum and / or a sodium chloride isotonic agent, an antibacterial agent, a pH value adjusting agent and injection water. The preparation disclosed by the invention is used for alleviating asthenopia and relieving xerophthalmia symptoms, has very high stability and can be preserved for a long time without a preservative.

Description

technical field [0001] The invention belongs to the field of ophthalmology, and in particular relates to an eye rinse solution combination preparation for improving and / or alleviating dry eye syndrome and visual fatigue and a preparation method thereof. Background technique [0002] In the field of ophthalmology, eye cleaning or washing is one of the effective means to relieve dry eye syndrome. In recent years, with the reduction of air quality and the increase in the frequency of use of electronic terminals, there are more and more patients with dry eye syndrome, and the potential sub-symptom patients are also increasing year by year. [0003] Patients with sub-dry eye symptoms are usually accompanied by visual fatigue in daily life. As people spend more and more time on electronic terminals and wear contact lenses (contact lenses) for a long time, it is easy to cause initial symptoms such as eye dryness, foreign body sensation, and visual fatigue. Decreased tear film sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/728A61K31/7016A61K31/205A61K31/198A61K47/40A61K47/36A61P27/02A61P27/04
CPCA61K9/0048A61K31/198A61K31/205A61K31/7016A61K31/728A61K47/36A61K47/40A61P27/02A61P27/04A61K2300/00
Inventor 牟亚男牟莹莹王良艳
Owner AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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