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Cross-linked hyaluronic acid and ectoin isotonic wound irrigating fluid

A technology of cross-linking hyaluronic acid and ectoine, applied in the field of infiltrating wound rinses, can solve the problems such as the inability to meet the needs of wound bed preparation, the single efficacy of wound rinses, and the inability to have both, and achieve strong absorption and The effect of locking the exudate ability, improving the immunity of skin cells, and protecting the wound

Pending Publication Date: 2020-06-05
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to solve the problems that the current wound irrigation solution has single efficacy, cannot well meet the needs of wound bed preparation, and cannot have the functions of debridement, wound protection, anti-adhesion and exudate management, etc., the present invention provides a cross-linked hyaluronic acid based Ketoin isotonic wound irrigating solution, which contains cross-linked hyaluronic acid and ectoine, has multiple functions such as debridement, wound protection, rapid hemostasis, exudate management, anti-adhesion and promoting healing, and simplifies wound healing. Bed preparation process with great market potential

Method used

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  • Cross-linked hyaluronic acid and ectoin isotonic wound irrigating fluid
  • Cross-linked hyaluronic acid and ectoin isotonic wound irrigating fluid
  • Cross-linked hyaluronic acid and ectoin isotonic wound irrigating fluid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] To investigate the hemostatic and healing effects of cross-linked hyaluronic acid ectoine isotonic wound irrigation solution.

[0036] 1. Prepare five sets of wound irrigation solution

[0037] (1) Prepare five groups of wound irrigating solutions according to the following process formula (Table 1), which are respectively group I, group II, group III, group IV and group V:

[0038] Table 1 wound irrigating fluid formula

[0039] test group Sodium hyaluronate 1,4-Butanediol diglycidyl ether Ekdoin Osmotic pressure 280~350mOsmol / kg Group I √ √ √ √ Group II —— √ √ √ Group III √ —— √ √ Group IV √ √ —— √ Group V √ √ √ ——

[0040] (2) Experimental group Ⅰ, Ⅲ, Ⅳ, and Ⅴ were all prepared with 0.9% NaOH solution to prepare 1.5% sodium hyaluronate solution. The molecular weight of sodium hyaluronate was 1000kD. No sodium hyaluronate added;

[0041] (3) Experimental Groups I, II, IV, and V added a cross-linking...

Embodiment 2

[0082] This example investigates the hemostatic effect of cross-linked hyaluronic acid ectoine isotonic wound irrigating fluid with different cross-linking degrees, and prepares three groups of cross-linked hyaluronic acid ectoine isotonic wound irrigating fluid, which are group Ⅰ and group Ⅱ respectively. , Group III, the preparation method is as follows:

[0083] (1) Using 0.9% NaOH solution to prepare sodium hyaluronate solution, the molecular weight of sodium hyaluronate is 1200kD, and the concentration is 1%;

[0084] (2) Add the cross-linking agent 1,4-butanediol diglycidyl ether to the above solution respectively, and react at 40°C for 8 hours at a pH of 8. Among them, the amount of the cross-linking agent in Group I, Group II, and Group III is the same as The mass ratios for the amount of hyaluronic acid or its salts are 1:140, 1:100, and 1:40, respectively. The concentration of crosslinking agent is 0.07‰, 0.1‰, 0.25‰ respectively;

[0085] (3) After the cross-linki...

Embodiment 3

[0090] (1) select each raw material and content according to the formula table of following table 6:

[0091] Table 6 wound irrigating liquid formula

[0092]

[0093] (2) Using 0.9% NaOH solution to prepare hyaluronate solution, the contents of each hyaluronate are shown in Table 6;

[0094] (3) Add the cross-linking agent 1,4-butanediol diglycidyl ether to each hyaluronate solution. The amount of the cross-linking agent added is shown in Table 6. The alkaline reaction is carried out at pH 8. Reaction 8h;

[0095] (2) Adjust the pH value of the reaction solution to 5 with 0.1% HCl, and purify the obtained cross-linked hyaluronate solution by semipermeable membrane dialysis. 280~350mOsmol / kg;

[0096] (3) The content of ectoine in the cross-linked hyaluronate solution purified by dialysis is as shown in Table 6 above, fully dissolved and mixed evenly, and finally three groups of different cross-linked hyaluronate ectoine are obtained More because of isotonic wound irrig...

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Abstract

The invention discloses a cross-linked hyaluronic acid and ectoin isotonic wound irrigating fluid. The irrigating fluid comprises cross-linked hyaluronic acid dialysate and ectoin; and the cross-linked hyaluronic acid dialysate is prepared by steps as follows: hyaluronic acid or hyaluronate is subjected to a cross-linking reaction with a cross-linking agent in an alkaline water environment, and the obtained reaction solution is dialyzed and purified by a phosphate buffer solution until osmotic pressure is 280-350 mOsmol / kg after pH value is regulated by acid. The osmotic pressure of the woundirrigating fluid is 280-350 mOsmol / kg, while the wound is cleaned, an active factor ectoin accelerates self-healing of injured cells due to capacity of improving immunity of skin cells, cross-linked hyaluronic acid attaching to the wound can continuously plays the function of autolytic debridement and is gathered on the wound surface to form a hyaluronic acid protecting membrane, and functions ofstopping bleeding, preventing tissue adhesion, resisting bacteria, protecting the wound and promoting healing are realized.

Description

technical field [0001] The invention relates to a cross-linked hyaluronic acid ectoine isotonic wound flushing liquid, which belongs to the technical field of medical wound flushing liquid. Background technique [0002] The theory of wound bed preparation is a new development in wound management in recent years. A wound bed is a wound surface, which refers to a wound surface that causes damage to the skin tissue for some reason, and is prone to infection and severe sepsis and other complications. Wound bed preparation is an optimized wound management plan to promote wound healing and improve treatment effect, including debridement, exudate management and infection control at different stages, emphasizing the use of holistic and systematic treatment methods to assess and eliminate Factors that influence the healing process so that wounds can heal under normal circumstances. [0003] At present, in the treatment of clinical wounds, the irrigating fluids used are generally nor...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/08A61K31/505A61K45/06A61K47/36A61P7/04A61P17/02A61P41/00
CPCA61K31/505A61K31/728A61K9/08A61K47/36A61K45/06A61P17/02A61P7/04A61P41/00A61K2300/00
Inventor 冯晓毅宋永民宫衍革姜秀敏甄文博刘栋郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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