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A kind of oil-free gel for treating acne and preparation method thereof

An oil gel, acne technology, applied in the field of oil-free gel for acne treatment and its preparation, to achieve the effect of good appearance quality, moderate consistency, and good spreadability

Active Publication Date: 2021-04-02
美健极生物工程技术(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no application of it in gel to improve the solubility of azelaic acid

Method used

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  • A kind of oil-free gel for treating acne and preparation method thereof
  • A kind of oil-free gel for treating acne and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment one, the preparation of modified sodium polyacrylate

[0027] S1. At 0°C, add 5% sodium hydroxide solution to 142g of acrylic acid for neutralization reaction. The neutralization degree is 70%. Add 0.30g of N,N-methylenebisacrylamide and stir well get the aqueous phase;

[0028] S2. Weigh 100g of cyclohexane and 100g of paraffin oil, add 10g of Span 80, 1g of fluorine-containing monoisocyanate monomer, 1.2g of stearyl methacrylate and 2.5g of lauryl methacrylate, and fully stir to obtain an oil phase; Mix the water phase and the oil phase at a ratio of 1:0.5, stir, slowly drop in 2g of ammonium persulfate and 1g of sodium bisulfite, heat to 45°C for 3 hours under nitrogen atmosphere, add 7.0g of Tween 80 after cooling, Stir for 20 minutes, then add methanol to precipitate, filter with suction, and dry to obtain modified sodium polyacrylate.

Embodiment 2

[0029] Embodiment two, the preparation of modified sodium polyacrylate

[0030] Compared with Example 1, the difference is that 1 g of fluorine-containing monoisocyanate monomer, 1.5 g of stearyl methacrylate and 2.0 g of lauryl methacrylate are added in the step S2, and the remaining parameters are the same as in Example 1.

Embodiment 3

[0031] Embodiment three, the preparation of modified sodium polyacrylate

[0032] Compared with Example 1, the difference is that 1 g of fluorine-containing monoisocyanate monomer, 1 g of stearyl methacrylate and 3 g of lauryl methacrylate are added in the step S2, and the remaining parameters are the same as those of Example 1.

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PUM

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Abstract

The invention relates to an oil-free gel for treating acne and a preparation method of the oil-free gel. The oil-free gel comprises the following components in percentage by mass: 10-20% of azelaic acid, 0.1-2% of salicylic acid, 1-3% of lac resin, 1-6% of sodium hyaluronate, 1-5% of modified sodium polyacrylate, 10-22% of 1, 3-propylene glycol and 50-70% of water. By adding the specific raw material, the problem of poor compatibility of azelaic acid is solved, the gel with high effective content of azelaic acid is formed, the gel does not contain oily components, is good in appearance quality, excellent in spreadability and moderate in consistency, the skin feels moist and soft after use, and the salicylic acid and the gel have a remarkable treatment effect on acnes in a synergistic manner. And the treatment apparent efficiency is up to 90% or above.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an oil-free gel for treating acne and a preparation method thereof. Background technique [0002] Azelaic acid is a saturated dicarboxylic acid, which is a kind of prismatic crystal extracted from rhododendron. It was discovered by Nazzaro-perro in 1983 that it has a significant therapeutic effect on acne. At a concentration of 20%, azelaic acid has a significant effect on acne patients. The effective mechanism of azelaic acid in treating acne is generally believed to be related to the effects of azelaic acid on eliminating pathogens such as propionibacterium, inhibiting hyperkeratosis of hair follicle epithelium, controlling skin oil secretion, and eliminating inflammation. [0003] Although azelaic acid has many good beauty effects, its compatibility is very poor, so it is difficult to form a complete beauty product. The specific reasons are as follows: ① Azelaic acid has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61K47/46A61K31/60A61K31/194A61P17/10
CPCA61K9/06A61K31/194A61K31/60A61K47/32A61K47/36A61K47/46A61P17/10A61K2300/00
Inventor 陈广文
Owner 美健极生物工程技术(广州)有限公司