A method for preparing 1-fluoronaphthalene by electrochemical fluorination

Abstract

The invention relates to a method for preparing 1-fluoronaphthalene by electrochemical fluorination, which comprises the following steps: adding a solvent into an electrolytic cell, turning on the stirring, adding substrate naphthalene, adding a fluorine source after completely dissolving, and connecting electrode sheets, Turn on the power supply, stir and react at a constant temperature to obtain 1-fluoronaphthalene. The invention has simple equipment, low equipment requirements, mild fluorination reaction conditions, no highly toxic or dangerous reagents, and can reduce pollution.

Description

technical field [0001] The invention relates to the field of electrochemical technology, in particular to a method for preparing 1-fluoronaphthalene by electrochemical fluorination. Background technique [0002] 1-Fluoronaphthalene is a drug intermediate developed in recent years. Since fluorine is the most active non-metallic element with the strongest electronegativity and its radius is similar to that of hydrogen atoms, when fluorine atoms are introduced into the drug, it has a A series of special properties, such as mimicry effect, lipophilicity, stability and so on. Therefore, many fluorine-containing drugs have lower toxicity, higher drug efficacy, stronger metabolism, and longer-lasting drug properties than fluorine-free drugs. Therefore, at present, fluorine-containing fine chemicals appear in various aspects of national defense and industrial production, and a group of fluorine-containing compounds with physiological activity have been successfully applied in the f...

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Problems solved by technology

The sodium nitrite used in the diazotization reaction is a secondary inorganic oxidant, which decomposes at 175°C and can cause combustion or explosion of organic matter; It will increase the concentration of nitrous acid, accelerate the decomposition of materials, produce a large amount of oxygen gas, and cause the danger of explosion and fire

Poor temperature control, prone to accidents, difficult to operate, low safety factor

[0005] 2. The amount of waste water is large and the cost is high

Because a large amount of sulfuric acid is used in the reaction process, a large amount of strong acid wastewater will be generated, and the temporary storage of strong acid wastewater has potential safety hazards, and the treatment of a large amount of strong acid wastewater will also increase the cost, resulting in high cost

[0006] 3. The process is cumbersome, and the product must be obtained through three or four steps of reaction

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