34results about How to "Avoid the three wastes" patented technology

The invention discloses a bright-ala-ruilin preparing method of solid-phase polypeptide, which comprises the following steps: adopting Wang resin or CTC resin as original material to connect amino with protective group to produce protective nonapeptide resin; removing Fmoc-protective group sequently; proceeding side-chain protective group synchronizingly and cutting peptide; connecting ethylaminethrough ethylamine-to-HOBT to produce crude product; proceeding separation and purifying through C18 (or C8) pillar to produce fine bright-ala-ruilin. The invention avoids the utility of poisonous agent, which improves the purifying, peptide connecting and obtaining rate.

The invention discloses an aoqu-peptide preparing method of solid-phase polypeptide, which comprises the following steps: adopting 2-chloride-trityl resin, 4-methyl trityl resin or 4-methoxyl trityl resin as raw material; connecting amino acid with protective group according to solid-phase synthetic method; obtaining protected octapeptide resin; removing Fmoc-protective group sequently; strippingside-chain protective group; cutting peptide to obtain reduced aoqu-peptide; oxidizing through air under pH 7-11 condition; separating and purifying rought product through C18 (C8) column to produce exquisite.

The invention discloses a preparation method of solid phase peptide synthesis triptorelin, which includes the following steps: with Rink Amide AM resins or Rink Amide MBHA resins as starting materials, amino acids with protective groups are sequentially connected according to solid phase synthesis, so as to obtain protective decapeptide resins, and meanwhile crude products are obtained by sequentially removing Fmoc-protective groups and synchronously removing side-chain protective groups and cutting peptides, and triptorelin elaborate products are prepared after the crude products are separated and purified by C18 (or C8 ) column and freeze-dried. The preparation method is stable in technology, convenient in raw and auxiliary material sources, short in production cycle, high in yield, stable in quality, low in production cost and high in transpeptidase yield. Besides, as the preparation method avoids using poisonous reagents, such as hydrogen fluoride, and the like, the pollution of three wastes is low, purification yield is over 25 percent and each step of transpeptidase yield is above 98 percent; the yield after cutting peptides is 78.8 percent and the total yield is 25.4 percent.

The invention discloses a preparation method of sulfophenylpyrazolone. The method uses compound (I) as a raw material, carries out a substitution reaction with compound (II) in the presence of a base, and then undergoes oxidation with an oxidant to prepare compound (III), compound (III) is esterified to obtain compound (IV), compound ( IV) Compound (VI) is obtained by thioreaction, compound (VI) is then oxidized, hydrolyzed (or hydrolyzed, oxidized) to obtain compound (VII), and compound (VII) is subjected to acid chloride to obtain acid chloride (VIII) and 1 , 3-dimethyl-5-hydroxypyrazole undergoes an esterification reaction to obtain compound (IX), and finally compound (IX) is rearranged to obtain compound (X). The beneficial effects of the invention are mainly reflected in the following: the raw materials are cheap and easy to obtain, the reaction conversion rate is high, the three wastes are few, and the industrial production is favorable.

Provided are a device and method for separating N-methylpyrrolidine, water and tetrahydrofuran. The device comprises a crude product dehydration working section and a product refining working section. The crude product dehydration working section comprises a crude product intermittent column, a first condenser, a phase splitting tank, a backflow head and the like. The crude product intermittent column comprises a crude steaming column reactor and a crude steaming column. The product refining working section comprises a refining intermittent column, a second condenser, a transition cut fraction receiving tan and a product receiving tank. The refining intermittent column comprises a rectifying column reactor and a rectifying column located at the top of the rectifying column reactor. The crude product dehydration working section is communicated with the rectifying column reactor of the product refining working section through a crude product storage tank communicated with the crude steaming column reactor. A two-column intermittent rectifying process is adopted in the method, water and tetrahydrofuran are taken out through the crude product intermittent column, left raw materials are purified through the product refining working section, and high-purity N-methylpyrrolidine is obtained. The problems that a traditional device and technique are large in energy consumption, low in yield, high in production cost and troublesome in aftertreatment are solved.

The invention relates to the field of fine chemical industry, and discloses a preparation method of 3,5-dichloro-2-pentanone, which is characterized in that the preparation method comprises: contacting α-acetyl-γ-butyrolactone and sulfuryl chloride in a system without a solvent to perform a chlorination reaction, then mixing the material obtained by the chlorination reaction with water, and adding hydrochloric acid dropwise to the obtained mixture to perform a ring-opening reaction. By using cheap industrial chemicals as raw materials, the method realizes a one-pot reaction without organic solvents, simplifies the process operation, reduces three wastes and production costs, and avoids the pollution caused by the use of metal catalysts.

The invention discloses a new preparation method of cyclopropanone, which includes adding ionic liquid into a microwave reactor, starting stirring, starting microwave heating, and raising the temperature to 100-140°C; at a temperature of 100-140°C, slowly and continuously Add α-acetyl-γ-butyrolactone, microwave promotes the catalytic cracking reaction of ionic liquid, and continuously extract the cracking product cyclopropanone and other steps through the rectification tower. The present invention uses microwaves to promote the catalytic cracking of ionic liquid raw material α-acetyl- γ-butyrolactone, under the conditions, the reaction has a high selectivity, and the reaction is almost free of impurities. The cyclopropanone content of the product obtained by the method is greater than 99%, and the total reaction yield is greater than 98%, which is much higher than Traditional methods and literature reports. During the reaction process, the production of three wastes is completely avoided, which protects the environment; it avoids possible dangers in the high-temperature production process, which is safer and conducive to improving operational efficiency.

The invention discloses an acrylonitrile-ethylene-styrene (AES) resin composition and a preparation method thereof. The composition comprises the following components in parts by weight: 10 to 50 parts of ethylene-propylene-diene monomer (EPDM) master batch, 50 to 90 parts of styrene-acrylonitrile (SAN) resin master batch, 0.02 to 0.2 part of initiator, 0.5 to 5 parts of co-crosslinker, and 0.3 to 1 part of antioxidant. The composition is prepared by adopting a reactive extrusion grafting method; and a compatilizer containing maleic anhydride (MAH) active functional groups, a compatilizer containing glycidyl methacrylate (GMA) active functional groups and modified EPDM and SAN resin are respectively prepared into the master batches, then other raw materials are added, the raw materials are stirred and mixed, and the mixture is extruded and granulated to form a sample. The reactive extrusion grafting method is environment-friendly, simple in equipment and convenient to operate; and the prepared composition has excellent weather resistance, low-temperature impact resistance, chemical corrosion resistance, size stability and processing performance, and can be applied to outdoor products such as building materials, sports equipment, communication equipment shells and automotive parts.

The application relates to a polymer material wrapping of Pigment Yellow 138 or its derivatives, its preparation method and its downstream products. The method is by mixing monoacid anhydride aromatic compounds, 8-aminoquinaldine compounds, solid organic acids and thermoplastic polymer materials, and adjusting the reaction molar ratio between each raw material and the amount of Pigment Yellow 138 or its derivatives in the final product. Mass content, so that their mixture can be extruded or kneaded, one step to obtain the polymer material wrapping of Pigment Yellow 138 or its derivatives, because the raw material reactants of Pigment Yellow 138 or its derivatives have better presence in polymer materials Excellent dispersibility, so they can be directly generated and uniformly dispersed in polymer materials during extrusion or kneading, and this process does not require adding any solvent, and does not require separation and purification after the reaction, avoiding the traditional pigment yellow 138 or its derivatives The generation of three wastes in the process of compound synthesis greatly simplifies the process and reduces energy consumption.

The invention relates to a method for preparing 1-fluoronaphthalene by electrochemical fluorination, which comprises the following steps: adding a solvent into an electrolytic cell, turning on the stirring, adding substrate naphthalene, adding a fluorine source after completely dissolving, and connecting electrode sheets, Turn on the power supply, stir and react at a constant temperature to obtain 1-fluoronaphthalene. The invention has simple equipment, low equipment requirements, mild fluorination reaction conditions, no highly toxic or dangerous reagents, and can reduce pollution.

The invention discloses ACS (acrylonitrile-chlorinated polyethylene-styrene) resin composition and a method for preparing the same. The ACS resin composition comprise the following components in parts by weight: 30-60 parts of chlorinated polyethylene resin masterbatch, 40-70 parts of SAN (styrene acrylonitrile) resin masterbatch, 0.02-0.2 part of initiator, 0.5-5 parts of assistant cross-linking agent, 0.3-1 part of antioxidant and 0.5-1.5 pars of heat stabilizer. The ACS resin composition is prepared by adopting a method of grafting by reactive extrusion according to the following steps: preparing masterbatches respectively from a compatibilizer containing an MAH (maleic anhydride) active functional group, a compatibilizer containing a GMA (glycidyl methacrylate) active functional group, chlorinated polyethylene resin and SAN resin, adding other raw materials, stirring and mixing, and extruding and granulating to obtain a sample. The method of grafting through reactive extrusion is more environmental friendly, the equipment is simple, the process is more convenient to operate, and the prepared ACS resin composition has excellent weather resistance and good anti-static properties, dimensional stability and processing performance.

Disclosed is a preparation method for an isoxazole compound and an intermediate thereof, the method comprising: a compound (I), as the starting material, is subjected to a substitution reaction with a compound (II) in the presence of a base, and subsequently to an oxidation reaction to prepare an intermediate acid (III); the intermediate acid (III) is methyl esterified to obtain an intermediate (IV); the intermediate (IV) is subjected to thionation to obtain an intermediate (VI); the intermediate (VI) is condensed with cyclopropyl methanone under a basic condition to obtain an intermediate (VIII); the intermediate (VIII) is subjected to alkene etherification reaction with ortho-formate and cyclized with hydroxylamine hydrochloride to obtain an intermediate (X); the methylthio of the intermediate (X) is oxidized by hydrogen peroxide to obtain isoxazole compound (XI). The starting material used in the present preparation method is readily available, and the preparation method has high productivity and purity, produces less industrial waste water, gas and residue, and has low cost and good industrial value.

The application relates to thermoplastic resin-wrapped pigment yellow 139 or its derivatives, its preparation method and its downstream products. The method mixes 1,3-diiminoisoindoline compounds, cyclic compounds containing meta-diketones, solid organic acids and thermoplastic resins, and adjusts the amount of each raw material, and then utilizes the thermoplastic resin as a reaction dispersion medium. The good processing performance and other related physical properties of the resin enable their mixture to be extruded or kneaded to obtain Pigment Yellow 139 or its derivatives wrapped in thermoplastic resin in one step, because in the process of extrusion or kneading, Pigment Yellow 139 or its derivatives The product can be directly generated and evenly distributed in the thermoplastic resin, without adding any solvent during the reaction, and without separation and purification after the reaction, avoiding the generation of three wastes, greatly simplifying the process and reducing energy consumption.