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A kind of taurine synthesis method

A synthetic method and technology of taurine, applied in the direction of sulfonic acid preparation, sulfonate preparation, chemical instruments and methods, etc., can solve problems such as high temperature and high pressure

Active Publication Date: 2022-07-12
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of synthetic method of taurine, solve the problem of high temperature and high pressure in the by-product in the addition reaction existing in existing taurine synthetic technology and ammonolysis reaction

Method used

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  • A kind of taurine synthesis method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The prepared 1000g sodium bisulfite solution (24wt%) was added to the reaction kettle, the temperature was controlled at 45°C, and then 106.7g of ethylene oxide was introduced, the reaction pressure was adjusted to 2bar, and the experiment was stopped after 45min. After cooling to room temperature, the addition reaction solution was selectively filtered using PM280 nanofiltration membrane, the filtration temperature was 30 °C, the pressure was 1 bar, and water was added after filtration to prepare. A 3% catalyst zirconia-supported ruthenium hydroxide was added to the 1L high-pressure reactor in advance, and the addition amount was 16.8g; 700g of the prepared sodium isethionate solution (18.0wt%) was added to the 1L high-pressure reactor In the process, liquid ammonia was introduced to make the concentration reach 19.0 wt%, the reaction system was heated to 110 °C, the system pressure was maintained at 4 MPa, and the reaction was carried out for 30 min. The yield of sodiu...

Embodiment 2

[0039] The prepared 1000g sodium bisulfite solution (10wt%) was added to the reaction kettle, the temperature was controlled at 25°C, 50.8g of ethylene oxide was then introduced, the reaction pressure was adjusted to 1bar, and the experiment was stopped after 10min. After cooling to room temperature, the addition reaction solution was selectively filtered using a PMS600 nanofiltration membrane, the filtration temperature was 10°C, the pressure was 0.1 bar, and water was added after filtration to prepare. A 4% catalyst zirconia-supported ruthenium hydroxide was added to the 1L high-pressure reactor in advance, and the addition amount was 17.6g; 705g of the prepared sodium isethionate solution (10.0wt%) was added to the 1L high-pressure reactor In the process, liquid ammonia was introduced to make the concentration reach 30.0wt%, the reaction system was heated to 80°C, the system pressure was maintained at 1MPa, and the reaction was performed for 10min. The yield of sodium taurin...

Embodiment 3

[0041] The prepared 1000g sodium bisulfite solution (30wt%) was added to the reaction kettle, the temperature was controlled at 95°C, and then 126.9g of ethylene oxide was introduced, the reaction pressure was adjusted to 7bar, and the experiment was stopped after 70min. After cooling to room temperature, the addition reaction solution was selectively filtered using PM280 nanofiltration membrane, the filtration temperature was 50 °C, the pressure was 5 bar, and water was added after filtration to prepare. A 5% catalyst titanium oxide-supported ruthenium hydroxide was added to a 1L high-pressure reactor in advance, and the addition amount was 2.84g (0.8wt%); 711g of the prepared sodium isethionate solution (40wt%) was added to In a 1L high-pressure reactor, liquid ammonia was introduced to make the concentration reach 25.0wt%, the reaction system was heated to 150°C, the system pressure was maintained at 5.5MPa, and the reaction was performed for 60min. The yield of sodium tauri...

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Abstract

The invention provides a safe and efficient method for synthesizing taurine, comprising the following steps: adding sodium bisulfite and ethylene oxide to obtain sodium isethionate; sodium isethionate and liquid ammonia at high temperature Ammonolysis reaction occurs under the following conditions to obtain sodium taurine; sodium taurine is subjected to acidification, crystallization and other steps to obtain pure taurine. The addition reaction filters the impurities through the nanofiltration membrane to eliminate the influence of side reactions. The aminolysis reaction conditions of the method of the invention are mild, the reaction residence time is shortened, and the industrialized production is safe and efficient.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparation, in particular to a method for synthesizing taurine, in particular to the removal of by-products in an addition solution and the optimization of an aminolysis reaction process. Background technique [0002] Taurine, also known as diethylsulfonic acid, is a sulfur-containing non-protein amino acid. Widely present in tissue cells, abundant in the brain. It has functions such as promoting the growth and development of the nervous system and cell differentiation, preventing cardiovascular diseases, affecting lipid absorption, improving immunity, and maintaining normal reproductive needs; therefore, it is widely used in medical treatment, health care, food, etc., and has a good market prospect. [0003] At present, the technology of artificial synthesis of taurine is relatively mature, and the main synthesis methods are ethanolamine method and ethylene oxide method. Among them, the ethylene ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C303/02C07C303/22C07C303/32C07C303/44C07C309/14B01J23/46
CPCC07C303/02C07C303/22C07C303/32C07C303/44B01J23/462C07C309/14
Inventor 蔺海政桂振友郭斌赵凯飞黄真真孔令晓丰茂英付广权陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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