Use of interferon in the preparation of medicines for preventing coronavirus infection or preventing diseases caused by coronavirus infection

Abstract

The present invention proposes the use of interferon in the preparation of medicines for preventing novel coronavirus infection or diseases caused by novel coronavirus infection and a medicine for preventing novel coronavirus infection or preventing novel coronavirus diseases. The drug can effectively prevent the infection of the novel coronavirus, significantly reduce the infection rate of the crowd and medical staff, avoid the spread of the epidemic, is easy to prepare, convenient to use and stable in quality, and can be effectively applied to the prevention of the novel coronavirus infection.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of interferon in the preparation of drugs for preventing coronavirus infection or diseases caused by coronavirus infection. Background technique [0002] The new coronavirus (2019-nCoV) is a new type of virus that broke out in December 2019. According to the nucleotide sequencing analysis of the virus, the virus belongs to the coronavirus, and the disease caused by the new coronavirus infection is named COVID -19. According to the WHO statement, CO stands for Corona (corona), VI stands for Virus (virus), D stands for Disease (disease), and 19 stands for 2019. At present, the virus has been officially named "SARS-CoV-2" by the International Virus Taxonomy Committee (Severe Acute Respiratory Syndrome Coronavirus 2). [0003] The transmission route of the new coronavirus is mainly through droplets. After the virus is inhaled into the nasal cavity through the air, the m...

AI Technical Summary

Problems solved by technology

Since then, the 2015 and 2019 editions of the "Guidelines for the Prevention and Treatment of Chronic Hepatitis B" have recommended the use of interferon / pegatron interferon alone for injection and the use of nucleoside drugs alone. Certain curative effect, and common interferon seroconversion rate is lower than long-acting interferon [Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2015 Edition)], while nucleoside antiviral drugs can strongly inhibit virus replication and improve liver inflammation [chronic hepatitis B]. Guidelines for the Prevention and Treatment of Hepatitis B (2019 Edition)]

At the same time, there are many contraindications to the use of interferon injection, which further limits the clinical application.

[0008] Although in the treatment part of the "New Coronavirus Pneumonia Diagnosis and Treatment Program" (Trial Fifth Edition, Revised Edition), it is mentioned that "a-interferon aerosol inhalation can be tried (5 million U or equivalent dose for adults each time, adding sterile injection 2ml of water, 2 times a day), lopinavir / ritonavir (200mg / 50mg, each capsule) 2 capsules each time, 2 times a day, or ribavirin (500mg / time, each capsule) can be added Intravenous infusion 2 to 3 times a day)" is the treatment plan, but it also mentions: "There is no confirmed effective antiviral treatment at present", so this treatment plan is only an inference based on the properties of the above drugs , its effect has not been verified by clinical experiments, and the effective rate is unknown. At the same time, according to the current treatment situation, this program is still not the main treatment program for new coronavirus pneumonia, and it has not been disclosed that this program can be used for novel coronavirus pneumonia. coronavirus prevention

And in this plan, α-interferon is in the form of aerosolization, and it may be combined with ribavirin injection. Its relatively complicated application method also determines that this treatment plan cannot be widely used in the prevention of new coronaviruses.