Nano drug carrier, drug-loading system containing nano drug carrier and preparation of drug-loading system

Abstract

The invention discloses a nano drug-loading system with a high drug load, a high photo-thermal conversion rate and a multi-factor response drug release function. Synthetic nano-level hollow CuS (copper sulfide) is adopted in the drug-loading system, CuS-PEG (copper sulfide-polyethylene glycol) is loaded and obtained through the combination of a metal sulfide and an amino group, an anti-cancer drugDOX (doxorubicin) is loaded through electrostatic adsorption and the hollow structure of CuS, and the nano drug carrier of CuS-PEG-DOX@HA type is obtained by loading HA through chemical bond combination.

Description

technical field [0001] The present invention relates to the field of pharmaceutical technology, in particular to a nano drug carrier with high drug loading capacity, high photothermal conversion rate and multi-factor responsive drug release function, a drug loading system comprising the nano drug carrier and a preparation method of the drug loading system . Background technique [0002] Malignant tumors caused by disordered cell division have seriously threatened human health. And these cells grow unrestricted beyond cell boundaries and have the ability to invade adjacent tissues and spread to other organs. Despite the rapid development of cancer diagnosis and treatment technology, there are still many types of cancer that cannot be cured. Chemotherapy (chemotherapy) is currently the most important treatment method for tumor treatment. However, due to the serious side effects of chemotherapeutic drugs, the design of drug carriers for chemotherapeutic drugs is a hot resear...

AI Technical Summary

Problems solved by technology

[0007] On the one hand, some drug carrier materials with light-to-heat conversion properties have poor biocompatibility, which may cause adverse reactions in the body, and may cause serious harm to normal cells and tissues of the organism when used.

At the same time, some materials have problems such as poor photothermal stability and low photothermal conversion efficiency, which cannot achieve the purpose of effective and continuous photothermal therapy.

[0008] On the other hand, some drug carrier materials have insufficient drug loading capacity, and the drug loading capacity is low, which will seriously affect the chemotherapy effect. When used, the dose needs to be increased, which greatly affects its biological safety.

Moreover, some drug carrier materials do not have specificity to cancer tissue, and it is difficult to realize the enrichment of materials in tumor tissue, which will not only greatly reduce its killing effect on tumor tissue, but also make chemotherapy drugs diffuse through normal physiological circulation. To each normal physiological tissue, it will have the same poisonous effect on normal cells and tissues, and it will have a relatively large side effect of chemotherapy on the organism, which will seriously affect its biological safety.

At the same time, in some drug carrier materials, the release ability of the loaded chemotherapeutic drugs is difficult to be regulated by the internal and external environment, and uncontrollable drug release easily occurs in non-tumor tissues in vivo, resulting in relatively large toxic and side effects and affecting chemical drugs. The effect of treatment

Images