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Dopamine assembly medicine delivery system and preparation method thereof

A delivery system and assembly technology, which is applied in the field of new dopamine assembly drug delivery system and its preparation, to achieve the effect of optimizing the therapeutic effect and easy operation

Inactive Publication Date: 2020-07-14
XI'AN PETROLEUM UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports at home and abroad on the co-assembly of dopamine and other molecules to prepare dopamine-based nanomaterials and apply them in tumor therapy.

Method used

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  • Dopamine assembly medicine delivery system and preparation method thereof
  • Dopamine assembly medicine delivery system and preparation method thereof
  • Dopamine assembly medicine delivery system and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1. Dissolving dopamine hydrochloride in a PBS buffer solution with a pH of 7.4 to prepare a dopamine hydrochloride solution with a concentration of 3 mM; dissolving glutaraldehyde in a PBS buffer solution with a pH of 7.4 to prepare a mass concentration of 0.06% glutaraldehyde solution; then according to the mass ratio of dopamine hydrochloride and glutaraldehyde is 1:2, the dopamine hydrochloride solution of 0.5mL 3mM and 0.5mL mass concentration are 0.06% glutaraldehyde The solution was shaken and mixed evenly, and the pH of the mixed solution was adjusted to 6.7 with hydrochloric acid and sodium hydroxide aqueous solution, and aged at room temperature for 2 hours to obtain a dopamine-glutaraldehyde assembly solution.

[0026] 2. Add 50 μL of 1 mg / mL adriamycin aqueous solution and 50 μL of 1 mg / mL chlorin e6 solution to the obtained dopamine and glutaraldehyde assembly solution obtained in step 1 (by 10 mg / mL of chlorin e6DMSO The solution was diluted with deionized ...

Embodiment 2

[0028] 1. Dissolve dopamine hydrochloride in a PBS buffer solution with a pH of 7.4 to prepare a dopamine hydrochloride solution with a concentration of 6 mM; dissolve oxidized sodium alginate in a PBS buffer solution with a pH of 7.4 to prepare a mass concentration 0.06% oxidized sodium alginate solution; then according to the molar ratio of dopamine hydrochloride and oxidized sodium alginate is 10:1, the dopamine hydrochloride solution of 6mM and the mass concentration are 0.06% oxidized sodium alginate The solution was oscillated and mixed evenly, and the total volume was 1 mL. The pH of the mixed solution was adjusted to 7.4 with hydrochloric acid and sodium hydroxide aqueous solution, and aged at room temperature for 4 hours to obtain a solution of dopamine and oxidized sodium alginate assembly.

[0029] 2. Add 50 μL of 1 mg / mL doxorubicin aqueous solution and 50 μL of 1 mg / mL chlorin e6 solution to the obtained dopamine and oxidized sodium alginate assembly solution obtai...

Embodiment 3

[0031] 1. Dissolving dopamine hydrochloride in a PBS buffer solution with a pH of 7.4 is prepared into a dopamine hydrochloride solution with a concentration of 8 mM; dissolving glutaraldehyde in a PBS buffer solution with a pH of 7.4 is prepared with a mass concentration of 0.2% glutaraldehyde solution; then according to the molar ratio of dopamine hydrochloride and glutaraldehyde is 2:5, the dopamine hydrochloride solution of 0.5mL 8mM and 0.5mL mass concentration are 0.2% glutaraldehyde The solution was shaken and mixed evenly, and the pH of the mixed solution was adjusted to 6.7 with hydrochloric acid and sodium hydroxide aqueous solution, and aged at room temperature for 4 hours to obtain a dopamine-glutaraldehyde assembly solution.

[0032] 2. Add 50 μL of 1 mg / mL bortezomib aqueous solution and 50 μL of 1 mg / mL phthalocyanine aqueous solution to the dopamine and glutaraldehyde assembly solution obtained in step 1, react under shaking at room temperature for 20 hours, and...

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Abstract

The invention discloses a dopamine assembly medicine delivery system and a preparation method thereof. The preparation method comprises the following steps: firstly, by using a covalence assembling method, co-assembling dopamine with a dopamine and aldehyde group cross-linking agent so as to obtain a dopamine and aldehyde group cross-linking agent nano assembly material; and adding a chemotherapydrug and a photodynamic therapy photosensitizer in the preparation process of the nano assembly material, and simultaneously loading two medicine molecules through adaptability packaging properties ofa nano material, so as to obtain the dopamine assembly medicine delivery system with pH response. The preparation method disclosed by the invention is simple and convenient to operate and controllable in height, and the prepared dopamine assembly medicine delivery system has the characteristics of being controllable in constitution, size and morphology, and the like, is capable of simultaneouslytaking treatment effects of cancer chemotherapy and photodynamic therapy into play, and has wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a novel dopamine assembly drug delivery system and a preparation method thereof. Background technique [0002] One of the hallmarks of malignant tumors is high heterogeneity. This heterogeneity leads to many problems in clinical treatment, such as multidrug resistance, drug leakage, narrow therapeutic window, etc. Faced with these problems, nanomedicine is used as a new platform for diagnosis, detection and treatment of malignant tumors. The use of nano-drug delivery systems can combine existing treatment methods to effectively overcome the limitations of monotherapy and achieve synergistic treatment of cancer. Nanotechnology-assisted combination therapy can not only control drug release, but also selectively target diseased tissues, as well as respond to external or internal stimuli. According to the environmental differences between tumor tissue and ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/18A61K47/36A61K47/08A61K41/00A61K31/704A61K38/05A61K31/513A61P35/00
CPCA61K9/5123A61K9/5161A61K31/513A61K31/704A61K38/05A61K41/0061A61K41/0071A61P35/00A61K2300/00
Inventor 李红赵媛媛熊珠珠史晓丹
Owner XI'AN PETROLEUM UNIVERSITY
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