Antibacterial hydrogel and preparation method and application thereof

A hydrogel, deionized water technology, applied in capsule delivery, pharmaceutical formulation, pharmaceutical science, etc., can solve the problems of easy killing of normal cells, high cytotoxicity, fast release, etc., and achieve excellent biocompatibility and mechanical properties. Good performance and antibacterial performance
CN111494702AActive Publication Date: 2020-08-07杭州口腔医院集团有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
杭州口腔医院集团有限公司
Publication Date
2020-08-07

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Abstract

The invention discloses antibacterial hydrogel, which is prepared from the following components: methacrylated chitosan and antibacterial microspheres, and the antibacterial microspheres are sodium alginate microspheres loaded with nano-silver, wherein a mass ratio of the methacrylated chitosan to the antibacterial microspheres is 10: (0.1-2). According to the preparation method, the nano-silver is loaded into the sodium alginate microspheres, so that the slow release of the nano-silver is realized. Meanwhile, the sodium alginate microspheres loaded with the nano-silver are added into the methacrylated chitosan hydrogel to form microsphere-containing antibacterial hydrogel, so that the antibacterial property of the material is greatly improved, the cytotoxicity of the nano-silver is reduced, and the release period of the nano-silver is as long as 10 days or longer. The antibacterial hydrogel disclosed by the invention is safe, non-toxic and good in antibacterial property, shows appropriate swelling and degradation behaviors, has excellent biocompatibility and mechanical properties, is biodegradable and bioabsorbable, and also has injectability and a hemostatic function.
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Description

technical field

[0001] The invention relates to the technical field of medical biomaterials, in particular to an antibacterial hydrogel and its preparation method and application. Background technique

[0002] Since the first discovery of penicillin in 1928, antibiotics have been widely used in the field of antibacterial. With the development of public health and biomedical technology, many infections have been effectively suppressed or even conquered. However, the use of antibiotics has led to the emergence of resistant microbes that are very difficult to kill, leading to more than 13 million deaths from infectious diseases worldwide each year. Corresponding resistant bacteria, such as floxacin-resistant Enterococcus (K-1476) and methicillin-resistant Staphylococcus aureus (MRSA), emerged almost immediately after the emergence of advanced antibiotics. In addition, traditional antibiotics face other problems, such as solubility, overdose, and cytotoxicity. Therefore, an e...

Claims

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