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Carbon nanotube modified electrode for acetaminophen detection and preparation method of carbon nanotube modified electrode

A paracetamol and carbon nanotube technology, applied in the field of electrochemical detection, can solve the problems of large overpotential, irreversible electrochemical reaction, low sensitivity, etc., and achieves low detection limit, simple and feasible preparation method, and high sensitivity. Effect

Pending Publication Date: 2020-08-07
广州钰芯传感科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, acetaminophen can be directly measured on the bare glassy carbon electrode by voltammetry, but its electrochemical reaction on the bare glassy carbon electrode is irreversible, the overpotential is large, and the sensitivity is not high. Substance, improve the sensitivity of electrode detection

Method used

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  • Carbon nanotube modified electrode for acetaminophen detection and preparation method of carbon nanotube modified electrode
  • Carbon nanotube modified electrode for acetaminophen detection and preparation method of carbon nanotube modified electrode
  • Carbon nanotube modified electrode for acetaminophen detection and preparation method of carbon nanotube modified electrode

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Experimental program
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Effect test

Embodiment 1

[0045] This embodiment provides a glassy carbon electrode modified with carbon nanotubes. The electrode adopts a three-electrode system, the surface of the working electrode is modified with a carbon nanotube layer, the surface of the counter electrode is modified with platinum, and the surface of the reference electrode is modified with silver-silver chloride.

[0046] The preparation method of the carbon nanotube modified electrode is as follows:

[0047] (1) Disperse multi-walled carbon nanotubes in 0.5% Nafion solution to obtain 1 mg / mL carbon nanotube modifier.

[0048] (2) Polish with alumina powders of 1.0 μm, 0.3 μm, and 0.05 μm respectively, then ultrasonically treat with 1:1 nitric acid, absolute ethanol, and ultrapure water for 1 minute each, and dry naturally for later use; 4 μL of carbon nanotube modification agent was drop-coated with a micro-syringe, and dried at room temperature to prepare a carbon nanotube-modified electrode.

Embodiment 2

[0050] This embodiment provides a glassy carbon electrode modified with carbon nanotubes. The electrode adopts a three-electrode system, the surface of the working electrode is modified with a carbon nanotube layer, the surface of the counter electrode is modified with platinum, and the surface of the reference electrode is modified with silver-silver chloride.

[0051] The preparation method of the carbon nanotube modified electrode is as follows:

[0052] (3) Disperse multi-walled carbon nanotubes in 0.5% Nafion solution to obtain 1 mg / mL carbon nanotube modifier.

[0053] (4) Polish with alumina powders of 1.0 μm, 0.3 μm, and 0.05 μm respectively, then ultrasonically treat with 1:1 nitric acid, absolute ethanol, and ultrapure water for 1 minute each, and dry naturally for later use; 6 μL of carbon nanotube modification agent was drop-coated with a micro-syringe, and dried at room temperature to prepare a carbon nanotube-modified electrode.

Embodiment 3

[0055] This embodiment provides a specific detection method for the determination of acetaminophen using a carbon nanotube modified electrode, which specifically includes:

[0056] (1) The carbon nanotube modified electrode prepared in Example 1 was scanned by cyclic scanning voltammetry in 0.10mol / L HAc-NaAc bottom solution for 8 weeks to activate the electrode;

[0057] (2) Prepare 1×10 with 0.10mol / L HAc-NaAc solution -4 The mol / L acetaminophen solution was placed in an electrolytic cell, enriched with the above-mentioned carbon nanotube modified electrode at 0.2V for 45 seconds, measured by square wave sweep voltammetry, and recorded a peak current of 0.46V.

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Abstract

The invention provides a carbon nanotube modified electrode for acetaminophen detection and a preparation method of the carbon nanotube modified electrode. Specifically, the surface of a glassy carbonelectrode is modified with carbon nanotubes, and the glassy carbon electrode is prepared into a detection electrode with three coplanar electrodes, so that accurate determination of acetaminophen isrealized. The carbon nano tube modification layer greatly improves the detection sensitivity and accuracy of the electrode; the electrode has the advantages of high sensitivity, low detection limit, good reproducibility, strong anti-interference capability and the like, the linear range of the electrode for determining acetaminophen is 1.0 * 10 <-4 >-1.0 * 10 <-7 > mol / L, and the detection limit of the electrode is 3.68 * 10 <-8 > mol / L.

Description

technical field [0001] The invention belongs to the field of electrochemical detection, and in particular relates to a carbon nanotube modified electrode used for detecting acetaminophen and a preparation method thereof. Background technique [0002] Acetaminophen (APAP for short), commonly known as paracetamol, is a common acetanilide antipyretic and analgesic drug, which is widely used clinically. APAP has certain toxic and side effects on the human body, and overdose can lead to liver necrosis, so its dosage is strictly controlled, and the determination of acetaminophen also has important practical significance. [0003] At present, the methods for determining acetaminophen are mainly external indicator method and internal indicator method, titration analysis, spectrophotometry, gas chromatography, and capillary electrophoresis. Among them, there are disadvantages such as low detection accuracy, large error, complex calculation, and inability to simultaneously measure mu...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/307G01N27/48
Inventor 奚亚男胡淑锦
Owner 广州钰芯传感科技有限公司
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