Wound adhesion hydrogel material as well as preparation method and application thereof

A technology for hydrogels and wounds, applied in applications, surgical adhesives, surgery, etc., can solve the problems of easy inhibition, reduction of inhibition effect, and restrictions, and achieve emergency response, ultra-high adhesion efficiency, and ultra-high adhesion The effect of indirect efficiency

Active Publication Date: 2020-08-11
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The strong reducibility of tannic acid makes it easy to inhibit polymerization, thus limiting its content in polyacrylic acid hydrogels
Protonated chitosan can combine with the phenolic hydroxyl group on tannic acid, thereby preventing the oxidation of tannic acid and reducing its inhibition effect

Method used

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  • Wound adhesion hydrogel material as well as preparation method and application thereof
  • Wound adhesion hydrogel material as well as preparation method and application thereof
  • Wound adhesion hydrogel material as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0050] The embodiment of the present invention also provides a preparation method of the above-mentioned wound adhesive hydrogel material, which adopts a one-pot polymerization method, and specifically includes:

[0051] Using the electrostatic interaction between polyacrylic acid and chitosan to form an interpenetrating network;

[0052] Cross-linking tannic acid with polyacrylic acid and chitosan in an interpenetrating network using aluminum ions as chelating agents; and

[0053] Adding methylene acrylamide BIS and bathing in water at 60-80° C. for 30-60 minutes obtains a wound-adhesive hydrogel material capable of repeated biological soft tissue-specific bonding.

[0054] In the preparation method of the above-mentioned wound adhesive hydrogel material, the hardness of the wound adhesive hydrogel material is regulated by changing the content of the aluminum ion chelating agent; and / or the adhesive is synthesized by changing the content of tannic acid Wound-adhesive hydroge...

Embodiment 1

[0057] Preparation method of wound adhesive hydrogel material and performance test of prepared wound adhesive hydrogel material

[0058] The preparation method of the wound adhesive hydrogel material: add 3g of acrylic acid and 0.2-0.3g of chitosan into 10-13g (77%) of distilled water and stir fully, then add 0.06-0.08g of nonahydrate aluminum nitrate, add 0.2-0.3 g tannic acid, add 10mg nitrogen nitrogen methylenebisacrylamide, and finally add 0.08g ammonium persulfate, stir well and put in a water bath at 60-80°C for 30-60 minutes to obtain a re-adhesive adhesive with super high adhesion efficiency. The attached wound adhesive hydrogel material.

[0059] The interaction of the components of the above wound-adhesive hydrogel materials was analyzed using infrared spectroscopy and scanning electron microscopy: infrared is figure 2 , comparing the infrared spectra of different substances, it shows that P-0.08Al-0.3C-0.3T (that is, the present invention, P represents polyacryli...

Embodiment 2

[0065] Example 2: Potential of the described wound-adhesive hydrogel materials as wearable device substrates.

[0066] Cut a spline with a length of 30mm, a width of 10mm, and a thickness of 2mm, and place it at the finger joint. Connect an external electrochemical workstation, bend your fingers 45° and 90°, and observe the changes in electrical signals, such as Figure 11 As shown, weak current stimulation can promote wound healing, indicating that the wound-adhesive hydrogel material has the potential as a substrate for wearable devices.

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Abstract

The invention discloses a wound adhesion hydrogel material as well as a preparation method and application thereof. The wound adhesion hydrogel material comprises main components including polyacrylicacid, chitosan, tannic acid and a chelating agent, wherein the polyacrylic acid and the chitosan form an interpenetrating polymer network (IPN) through an electrostatic interaction; the tannic acid is used for enhancing the viscosity and acidity of wound adhesion hydrogel; and the chelating agent is used for crosslinking the tannic acid with the polyacrylic acid and the chitosan in the IPN. The wound adhesion hydrogel material shows higher bonding strength in the air and water, can realize repeated bonding, has bonding stability, is not affected by acids or bases, shows specific bonding to biological soft tissue in water, and has antibacterial capacity and remarkable heal promoting capacity for wounds. Due to the stable bonding strength, high bonding efficiency and repeated bonding of thewound adhesion hydrogel material, the operation time can be substantially saved, the specific bonding of the wound adhesion hydrogel material to the biological soft tissue underwater also facilitatesoperation by a doctor, and the pain of a patient can be reduced. In addition, the wound adhesion hydrogel material also has the potential of being used as wearable equipment substrate.

Description

technical field [0001] The invention relates to a wound adhesive hydrogel material capable of repeatedly using biological soft tissue superadhesion and antibacterial functions, a preparation method and an application thereof, belonging to the technical field of biomedical materials. Background technique [0002] In recent years, many emerging biomedical materials have been used for wound or wound healing, including porous sponges, electrospinning, biofilms, etc. How to quickly stop bleeding and promote tissue self-healing has become the focus of material design. However, the above-mentioned materials need to be bandaged in actual operation, and the wound treatment process is more professional. The demand for convenient and non-invasive wound adhesive tapes like Band-Aids is increasing, and viscous hydrogel materials have gradually entered people's field of vision. [0003] Hydrogel materials are water-dispersed polymer chains with excellent air permeability, but the wound i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/06C08J3/075C08L33/02C08L5/08C08K5/134
CPCA61L24/001A61L24/0015A61L24/0031A61L24/043A61L2300/216A61L2300/404C08J3/075C08J2305/08C08J2333/02C08K5/1345C08L33/02C08L5/08
Inventor 黄建永田卓灵苏醒
Owner PEKING UNIV
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