Conjugated polymer quantum dot and preparation method and application thereof

A conjugated polymer, quantum dot technology, applied in chemical instruments and methods, measuring devices, material excitation analysis, etc., can solve the problems of dilute colloidal solution concentration, large solvent consumption, complex preparation process, etc., and achieve mild reaction conditions, The effect of improving the reaction yield and simplifying the reaction steps

Active Publication Date: 2020-08-11
ANHUI NORMAL UNIV
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Problems solved by technology

Therefore, the current preparation of conjugated polymer quantum dots is largely limited by the harsh synthetic conditions of conjugated polymers, including high temperature, large solvent consumption, the need for noble metal catalysts, and tedious and time-consuming purification operations.
At the same time, the types of polymer monomers that can be obtained at present are also very limited and the prices are generally high
In addition, the above-mentioned methods also generally need auxiliary agents (organic solvents or surfactants) when preparing polymer nanomaterials, the amount of single preparation is small, and the concentration of the obtained colloidal solution is dilute.
In general, the existing methods for preparing conjugated polymer quantum dots have the following problems: complex preparation process, waste liquid discharge, inability to prepare in large quantities, few varieties, high cost, etc.

Method used

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  • Conjugated polymer quantum dot and preparation method and application thereof
  • Conjugated polymer quantum dot and preparation method and application thereof
  • Conjugated polymer quantum dot and preparation method and application thereof

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preparation example Construction

[0034] The invention provides a preparation method of conjugated polymer quantum dots, comprising:

[0035] 1) in the presence of a catalyst, the phenylenediamine compound and the benzoquinone compound are contacted in water;

[0036] 2) The pH of the reaction system is adjusted to neutral or alkaline, followed by purification to obtain conjugated polymer quantum dots.

[0037] In the above preparation method, in order to further improve the fluorescent properties of the conjugated polymer quantum dots, preferably, in step 1), the molar ratio of the phenylenediamine compound and the benzoquinone compound is 0.4 mmol: 0.1-0.4 mmol, more preferably 0.4 mmol: 0.2-0.3 mmol. Controlling the amount of phenylenediamine compounds to be greater than the amount of benzoquinone compounds can make the surface modification of the conjugated polymer quantum dots have more amino groups.

[0038] In the above preparation method, in order to further improve the fluorescent properties of the ...

Embodiment 1

[0052] Preparation of Conjugated Polymer Quantum Dots:

[0053] 1) Dissolve catechol and o-phenylenediamine in ultrapure water to prepare solutions with a concentration of 0.4mol / L respectively for subsequent use.

[0054] 2) In a 10ml centrifuge tube, add 0.8mL of 20 wt% H 2 o 2 (contains 5.33mmol H 2 o 2 ), 2ml of catechol solution (containing 0.8mmol catechol), and reacted for 3min at 25°C (after the reaction, it was detected by high performance liquid phase that the system contained 0.3mmol of catechol).

[0055] 3) Add 1mL o-phenylenediamine solution (containing 0.4mmol o-phenylenediamine) to the above solution, then add 1mL 2mol / L hydrochloric acid (containing 2mmol hydrogen chloride) to it, and react in the dark at 25°C for 4h.

[0056] 4) To the reaction system, add a NaOH solution with a pH of 11 to accelerate polymerization and precipitation. After the addition of the NaOH solution, the pH of the reaction system is 8 to stop the reaction. After the reaction syst...

Embodiment 2

[0058] Carry out according to the method for embodiment 1, difference is that o-phenylenediamine is replaced by m-phenylenediamine.

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Abstract

The invention discloses a conjugated polymer quantum dot as well as a preparation method and application thereof, and the preparation method comprises the following steps: 1) in the presence of a catalyst, carrying out a contact reaction on a phenylenediamine compound and a benzoquinone compound in water; and 2) adjusting the pH value of the reaction system to be neutral or alkaline, and purifyingto obtain the conjugated polymer quantum dot. The preparation method has the characteristics of rapidness, low cost and easiness in realization, and the conjugated polymer quantum dot has excellent fluorescence imaging characteristics, so that the conjugated polymer quantum dot can be applied to biological imaging.

Description

technical field [0001] The present invention relates to a conjugated polymer quantum dot, in particular to a conjugated polymer quantum dot and its preparation method and application. Background technique [0002] In recent years, due to the rapid development of the fluorescence microscopy industry, fluorescence imaging technology has become an indispensable tool in the fields of chemistry, biology and medicine. As an important part of imaging technology, fluorescent reagents largely determine the performance of imaging, such as resolution and penetration depth. Traditional fluorescent probes, including small organic molecules, inorganic quantum dots (Qdots), and green fluorescent protein (GFP), have played an important role in the development of fluorescence imaging, but there are also many limitations, such as low brightness, light Insufficient stability or toxicity concerns. Therefore, seeking new high-performance fluorescent imaging reagents has important practical sig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/00C09K11/06G01N21/64
CPCC08G73/00C09K11/06G01N21/6428G01N21/6486G01N21/6456G01N21/6458C09K2211/1425C09K2211/1433
Inventor 孙军勇陈宁宁张荣超张强高峰
Owner ANHUI NORMAL UNIV
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