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Trollius chinensis heat-clearing anus suppository and preparation method thereof

An anal suppository and Jinlian technology, applied in the field of Jinlian Qingre anal suppository and its preparation, to achieve high dissolution rate, convenient administration, and adaptability to a wide range of patient groups

Inactive Publication Date: 2020-08-18
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no suppository that uses Jinlian Qingre as a drug to treat exogenous heat syndrome

Method used

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  • Trollius chinensis heat-clearing anus suppository and preparation method thereof
  • Trollius chinensis heat-clearing anus suppository and preparation method thereof
  • Trollius chinensis heat-clearing anus suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Preparation of Jinlian Qingre Compound Extract:

[0069] Take 1400g nasturtium, 1600g Daqingye, 1100g gypsum, 700g Anemarrhena, 800g Rehmannia glutinosa, 800g Scrophulariaceae, 1150g fried bitter almonds, add 7 times the amount of water and 0.3% of the quality of the medicinal material SPE -007, heat in a water bath to 40°C, keep warm for 8 minutes, and decoct for 90 minutes after deactivating the enzyme; then add water 5-6 times the weight of the medicinal material, decoct for 40 minutes, combine the two decoctions, and filter; put the filtrate on the column , separated by macroporous resin, eluted with 60% ethanol, recovered ethanol in the eluent, and concentrated under reduced pressure to an extract with a relative density of 1.25 (50° C.), to obtain a compound extract of Jinlian Qingre.

[0070] Preparation of anal suppositories:

[0071] Get the golden lotus heat-clearing compound extract, matrix (semi-synthetic palm oil ester) that mass ratio is 0.8:1, the golden...

Embodiment 2

[0074] Preparation of Jinlian Qingre Compound Extract:

[0075] Take 1500g nasturtium, 1500g Daqingye, 1125g gypsum, 750g Anemarrhena, 750g Rehmannia glutinosa, 750g Scrophulariaceae, 1125g fried bitter almonds, add 8 times the amount of water and 0.35% of the quality of the medicinal material SPE -007, heated to 40°C in a water bath, kept warm for 8 minutes, decocted for 90 minutes after deactivating the enzyme; then added water with 5 times the mass of medicinal materials, decocted for 40 minutes, combined the two decoction liquids, and filtered; put the filtrate on the column, large Pore ​​resin separation, eluting with 60% ethanol, recovering the ethanol in the eluent, concentrating under reduced pressure to an extract with a relative density of 1.20 (50° C.), to obtain the compound extract of Jinlian Qingre.

[0076] Preparation of anal suppositories:

[0077] Get the polysorbate 80 of Jinlian Qingre compound extract, matrix (semi-synthetic fatty acid ester) that mass ra...

Embodiment 3

[0080] The preparation of Jinlian heat-clearing compound extract: 1600g nasturtium flower, 1600g Daqingye, 1200g gypsum, 800g Zhimu, 800g rehmannia glutinosa, 800g Scrophulariaceae, 1200g fried bitter almond, add 8 times the amount of medicinal material quality water and 0.3% medicinal material quality Plant essence extraction compound enzyme SPE-007, heated to 40°C in a water bath, kept warm for 10 minutes, decocted for 90 minutes after inactivating the enzyme; then added 6 times the amount of medicinal material, decocted for 40 minutes, combined the two decoctions, and filtered; Put the filtrate on the column, separate the macroporous resin, elute with 60% ethanol, recover the ethanol in the eluate, and concentrate under reduced pressure to the extract with a relative density of 1.30 (50°C) to obtain the compound extract of Jinlian Qingre.

[0081] Preparation of anal suppositories:

[0082] Get the sucrose ester of Jinlian Qingre compound recipe extract and matrix (mixed fa...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to a trollius chinensis heat-clearing anus suppository and a preparation method thereof. The anoectochilus formosanusheat-clearing anus suppository is prepared from an anoectochilus formosanus heat-clearing compound extract and a matrix, and the mass ratio of the anoectochilus formosanus heat-clearing compound extract to the matrix is (0.5-0.8): 1. The anoectochilus formosanus heat-clearing anus suppository contains an anoectochilus formosanus heat-clearing compound extract and a surfactant accounting for 1.5-2% of the total mass of the matrix. Compared with the prior art, the anoectochilus formosanus heat-clearing anus suppository overcomes the defects of poor direct absorption, low bioavailability and large dosage of an anoectochilus formosanus heat-clearing oral preparation, and is good in stability, high in bioavailability, convenient and safe to administrate and wider in application range to patient groups.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a Jinlian heat-clearing anus suppository and a preparation method thereof. Background technique [0002] Heat syndrome due to exogenous pathogenic factors refers to the symptoms of feeling the evil of the six evils or the warm and epidemic poison, which leads to the imbalance of health and camp, the imbalance of yin and yang in viscera, pathological rise in body temperature, accompanied by aversion to cold, red face, irritability, rapid pulse, etc. It is a type of heat syndrome caused by exogenous pathogenesis as the main clinical manifestation. Exogenous heat syndrome has the characteristics of rapid onset and rapid change of condition, which requires timely diagnosis and targeted treatment according to the etiology in a short period of time. At present, antiviral drugs such as acyclovir, ribavirin, and amantadine are mainly used in clinical treatment for patients ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/02A61K47/22A61K47/10A61K47/12A61P29/00A61K33/06
CPCA61K9/0031A61K9/02A61K33/06A61K36/195A61K36/315A61K36/704A61K36/71A61K36/736A61K36/804A61K36/808A61K36/855A61K36/8964A61K47/10A61K47/12A61K47/22A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P29/00A61K2300/00
Inventor 窦啟玲李芙蓉熊敏
Owner GUIZHOU YIBAI PHARMA CO LTD
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