Trollius chinensis heat-clearing anus suppository and preparation method thereof

An anal suppository and Jinlian technology, applied in the field of Jinlian Qingre anal suppository and its preparation, to achieve high dissolution rate, convenient administration, and adaptability to a wide range of patient groups

Inactive Publication Date: 2020-08-18
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no suppository that uses Jinli

Method used

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  • Trollius chinensis heat-clearing anus suppository and preparation method thereof
  • Trollius chinensis heat-clearing anus suppository and preparation method thereof
  • Trollius chinensis heat-clearing anus suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0067] Example 1

[0068] Preparation of Jinlian Qingre Compound Extract:

[0069] Take 1400g nasturtium, 1600g big green leaves, 1100g gypsum, 700g anemarrhena, 800g rehmannia, 800g scrophulariaceae, 1150g sauteed bitter almonds and mix, add 7 times the mass of medicinal material water and 0.3% of the medicinal material quality plant extract complex enzyme SPE -007, heat the water bath to 40℃, keep for 8min, decoct for 90min after the enzyme is inactivated; then add 5-6 times the weight of the medicinal material, decoc for 40min, combine the two decoctions, filter; put the filtrate on the column , Macroporous resin separation, elution with 60% ethanol, recovery of ethanol in the eluate, and concentration under reduced pressure to a relative density of 1.25 (50° C.) extract to prepare Jinlian Qingre compound extract.

[0070] Preparation of anal suppositories:

[0071] Take the golden lotus heat-clearing compound extract and the matrix (semi-synthetic palm oil ester) with a mass rati...

Example Embodiment

[0073] Example 2

[0074] Preparation of Jinlian Qingre Compound Extract:

[0075] Take 1500g of nasturtium, 1500g of green leaves, 1125g of gypsum, 750g of Anemarrhena, 750g of Dihuang, 750g of Scrophulariaceae, and 1125g of sauteed bitter almonds, add 8 times the amount of water and 0.35% of the weight of the medicinal material to the plant extract complex enzyme SPE -007, heat in a water bath to 40℃, keep for 8min, decoct for 90min after inactivating the enzyme; then add 5 times the mass of the medicinal material, decoct for 40min, combine the two decoctions, filter; put the filtrate on the column, large The pore resin is separated and eluted with 60% ethanol, the ethanol in the eluate is recovered, and the extract is concentrated under reduced pressure to a relative density of 1.20 (50°C) to prepare the Jinlian Qingre compound extract.

[0076] Preparation of anal suppositories:

[0077] Take the golden lotus heat-clearing compound extract and matrix (semi-synthetic fatty acid es...

Example Embodiment

[0079] Example 3

[0080] Preparation of Golden Lotus heat-clearing compound extract: 1600g nasturtium, 1600g big green leaves, 1200g gypsum, 800g anemarrhena, 800g rehmannia, 800g scrophulariaceae, 1200g sauteed bitter almonds, mixed with 8 times the mass of medicinal material and 0.3% of the mass of medicinal material Plant extract compound enzyme SPE-007, heat in a water bath to 40℃, keep for 10 minutes, decoct for 90 minutes after inactivating the enzyme; then add 6 times the mass of the medicinal material, decoct for 40 minutes, combine the two decoctions, and filter; The filtrate was applied to a column, separated by a macroporous resin, and eluted with 60% ethanol. The ethanol in the eluate was recovered and concentrated under reduced pressure to an extract with a relative density of 1.30 (50° C.) to prepare the Jinlian Qingre compound extract.

[0081] Preparation of anal suppositories:

[0082] Take the golden lotus heat-clearing compound extract and matrix (mixed fatty aci...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to a trollius chinensis heat-clearing anus suppository and a preparation method thereof. The anoectochilus formosanusheat-clearing anus suppository is prepared from an anoectochilus formosanus heat-clearing compound extract and a matrix, and the mass ratio of the anoectochilus formosanus heat-clearing compound extract to the matrix is (0.5-0.8): 1. The anoectochilus formosanus heat-clearing anus suppository contains an anoectochilus formosanus heat-clearing compound extract and a surfactant accounting for 1.5-2% of the total mass of the matrix. Compared with the prior art, the anoectochilus formosanus heat-clearing anus suppository overcomes the defects of poor direct absorption, low bioavailability and large dosage of an anoectochilus formosanus heat-clearing oral preparation, and is good in stability, high in bioavailability, convenient and safe to administrate and wider in application range to patient groups.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a Jinlian heat-clearing anus suppository and a preparation method thereof. Background technique [0002] Heat syndrome due to exogenous pathogenic factors refers to the symptoms of feeling the evil of the six evils or the warm and epidemic poison, which leads to the imbalance of health and camp, the imbalance of yin and yang in viscera, pathological rise in body temperature, accompanied by aversion to cold, red face, irritability, rapid pulse, etc. It is a type of heat syndrome caused by exogenous pathogenesis as the main clinical manifestation. Exogenous heat syndrome has the characteristics of rapid onset and rapid change of condition, which requires timely diagnosis and targeted treatment according to the etiology in a short period of time. At present, antiviral drugs such as acyclovir, ribavirin, and amantadine are mainly used in clinical treatment for patients ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/02A61K47/22A61K47/10A61K47/12A61P29/00A61K33/06
CPCA61K9/0031A61K9/02A61K33/06A61K36/195A61K36/315A61K36/704A61K36/71A61K36/736A61K36/804A61K36/808A61K36/855A61K36/8964A61K47/10A61K47/12A61K47/22A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P29/00A61K2300/00
Inventor 窦啟玲李芙蓉熊敏
Owner GUIZHOU YIBAI PHARMA CO LTD
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