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Traditional Chinese medicine formula flora capsule, preparation method and application thereof in preparing medicine for treating type 2 diabetes mellitus

A technology of traditional Chinese medicine and formula, applied in the direction of medical formula, capsule delivery, drug combination, etc., can solve the problems of limited physiological and psychological acceptance of patients, limit the popularization and application of treatment technology, and not included in the control group, etc., to achieve comfortable treatment approach, treatment Significant effect, the effect of improving the therapeutic effect

Active Publication Date: 2020-08-18
NANJING FMT MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, although the above-mentioned administration methods can achieve the purpose of enterobacteria transplantation treatment, they need to infuse the bacteria solution into the patient's intestinal tract under a catheter or endoscope, and the patient's physiological and psychological acceptance is limited, thus limiting this. The popularization and application of treatment technology in clinic
For example, Tian Hongliang et al. (analysis of clinical curative effect analysis of 15 cases of chronic transit constipation treated with flora capsules, Chinese Journal of Practical Surgery, Vol. 36, No. 4, April 2016) reported clinical curative effect analysis of 15 cases of chronic transit constipation treated with flora capsules, but The research results are preliminary attempts, and the control group has not been included. How to overcome the shortcomings of fecal microbiota transplantation is still not enough

Method used

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  • Traditional Chinese medicine formula flora capsule, preparation method and application thereof in preparing medicine for treating type 2 diabetes mellitus
  • Traditional Chinese medicine formula flora capsule, preparation method and application thereof in preparing medicine for treating type 2 diabetes mellitus
  • Traditional Chinese medicine formula flora capsule, preparation method and application thereof in preparing medicine for treating type 2 diabetes mellitus

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Experimental program
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Effect test

Embodiment 1

[0039] Embodiment 1: Extract flora

[0040] The invention uses the intelligent fecal bacteria separation system to automatically separate and extract disposable consumable components, wherein the intelligent fecal bacteria separation system is a microorganism separation device in the cavity content, the patent number is: ZL201410606325.4, or a stool analysis pretreatment instrument , Model: FMT-5A-50 / FMT-6A-50. Disposable consumables include filter bottle 3, isolate tank 4, sub-bottling bottle 5, deodorizing device 8, liquid absorption and deodorizing buffer bottle 11, bacteria solution pipeline 22, and the like.

[0041] The main steps of the flora extraction method of the present invention are as follows:

[0042] Use sterile original jars (sterile disposable consumables, the structure of which is as follows figure 2As shown) Collect 200g of feces samples from healthy donors, seal them and send them to the aseptic operation room, cooperate with filter bottle 3, isolate ta...

Embodiment 2

[0046] Embodiment 2: Chinese medicine extraction

[0047] Use the traditional concentrated extraction method to extract the effective components of traditional Chinese medicine (for the extraction process of traditional Chinese medicine, please refer to image 3 ), the specific method is as follows:

[0048] According to the weight ratio of 10:15:15:10:10, take the medicinal materials American ginseng, Polygonatum, Divine Comedy, Digupi, and Curcuma, properly chop or pulverize them, and put them in a decoction container.

[0049] Add an appropriate amount of water to immerse the medicinal materials and soak for a suitable time.

[0050] Heat to boiling, leaching for a certain period of time, separate the decoction liquid, decoct the medicinal residues 2-3 times according to the law, and collect the decoction liquid.

[0051] Evaporate the water decoction to a specific gravity of 1:1, add 2 times of ethanol after cooling, mix well, let it stand overnight to make it precipitat...

Embodiment 3

[0053] Embodiment 3: Preparation of Chinese medicine formula flora capsule

[0054] For the technical process of Chinese medicine formula flora Figure 5 , the flora freeze-dried powder in Example 1, and the extracted Chinese medicine extract powder in Example 2 are mixed in a ratio of 1:1 by volume, and then stirred and mixed with a micro-mixer to obtain a Chinese medicine formula flora, and acid-resistant Hypromellose capsule filling, each capsule contains 1.5 grams of traditional Chinese medicine powder, 1.5 grams of bacterial powder, and then packed in a sealed bag and stored in a -20 ° C refrigerator.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine formula flora capsule which is prepared by matching freeze-dried powder separated from coprophilous fungi and traditional Chinese medicine extraction powder obtained by crushing traditional Chinese medicine extraction effective components. The traditional Chinese medicine formula flora capsule is prepared by combining a traditional Chinese medicine extraction method and deeply fusing the traditional Chinese medicine extraction method with a coprophilous fungi separation process, the treatment effect is greatly improved while the administration method is changed, and an efficient and comfortable treatment way is realized.

Description

technical field [0001] The invention belongs to the technical field of medicines, specifically relates to the technical field of fecal bacteria transplantation, and more specifically relates to a traditional Chinese medicine formula fecal bacteria capsule, a preparation method thereof, and an application in preparing a medicine for treating type 2 diabetes. Background technique [0002] Changes in the structure and function of intestinal flora can cause a series of metabolic diseases such as obesity and type 2 diabetes. Recent studies have suggested that fecal microbiota transplantation can improve blood sugar control in type 2 diabetes, improve metabolism, and improve insulin sensitivity. [0003] "Fecal microbiota transplantation" (FMT) is defined as the transplantation of functional flora in the feces of healthy people into the stomach of patients through nasogastric or duodenal tubes, gastroscopy or colonoscopy, rectal catheter enema, etc. In the intestinal tract, rebuil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61P3/10A61K35/74
CPCA61K36/258A61K36/8969A61K36/00A61K36/815A61K36/9066A61K35/74A61K9/4816A61P3/10A61K2236/331A61K2300/00
Inventor 徐福宁徐传友黄红丽陈庆林盛健徐奚如
Owner NANJING FMT MEDICAL
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