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A kind of nasal cavity filling material and preparation method thereof

A filling material and nasal cavity technology, which can be applied in medical formula, surgery, drug delivery, etc., can solve problems such as lack of hemostatic and antibacterial functions, prone to bending and fracture, and insufficient compression force, so as to reduce the use of clinical antibiotics and improve bending resistance Folding performance and pressure resistance, the effect of preventing infection

Active Publication Date: 2021-10-22
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application CN107075165A discloses an elastic hemostatic foam made of sodium carboxymethyl cellulose, which has good biocompatibility, high water absorption and high elasticity, and can become a hydrogel after absorbing liquid in the body It is excreted from the body and does not need to be taken out after surgery. However, the material itself does not have the function of hemostasis and antibacterial function. Only by absorbing liquid to force hemostasis, the mechanical properties of the material decline rapidly after absorbing liquid, and it is prone to bending and fracture, and there may still be defects of insufficient compression force.
Chinese patent application CN108992701A discloses a composite hemostatic material prepared by chitosan, sodium carboxymethyl cellulose, nano-titanium dioxide and polyvinyl alcohol fiber. Promote hemostasis, antibacterial and other functions, polyvinyl alcohol fiber provides a basic framework for it to have the advantages of high expansion, good bending performance, etc., but chitosan is an animal-derived material, there are applications such as virus infection and immunogenic reaction At the same time, the degradation in the body is slow, and there is still the disadvantage of needing to be removed after surgery when used as a nasal packing hemostatic material
[0006] In view of the fact that the nasal cavity filling materials commonly used in this field and some nasal cavity filling materials disclosed in this field cannot meet the requirements of no cytotoxicity, no sensitization, certain mechanical properties, effective degradation in the nasal cavity, and good hemostasis and anti-adhesion Therefore, there is an urgent need to develop a nasal filling material with good biocompatibility, high expansion, bending resistance, good liquid absorption, rapid degradation and significant hemostatic and antibacterial properties in this field. , which has important clinical significance for the implementation of nasal endoscopic surgery and postoperative recovery

Method used

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  • A kind of nasal cavity filling material and preparation method thereof
  • A kind of nasal cavity filling material and preparation method thereof
  • A kind of nasal cavity filling material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1, preparation of nasal cavity filling material A

[0046] (1) Modification of carboxymethyl cellulose: Add 3.0 g sodium carboxymethyl cellulose (average molecular weight 250,000 Daltons, degree of substitution 0.9) into 100 mL of purified water, fully stir and dissolve in a water bath at 60°C to obtain The aqueous solution of sodium carboxymethyl cellulose, the aqueous solution is cooled to room temperature, and the addition of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with a mass percentage of 1.5% carries out 30min activation treatment, and the reaction pH Maintain at 4-5, then add 1% ε-polylysine to react for 8 hours, after the reaction, use pure water as the dialysis medium to carry out dialysis treatment for 6 hours, and freeze-dry the product after dialysis to obtain polylysine-modified Freeze-dried powder of carboxymethylcellulose.

[0047] (2) Preparation of nasal cavity filling material A: dissolve polylysine-modified carboxymethyl cellulose ...

Embodiment 2

[0048] Embodiment 2, the preparation of nasal filling material B

[0049] (1) Modification of carboxymethyl cellulose: Add 3.0 g of sodium carboxymethyl cellulose (average molecular weight 250,000 Daltons, degree of substitution 0.9) into 100 mL of purified water, fully stir and dissolve in a water bath at 60°C, Obtain an aqueous solution of sodium carboxymethylcellulose and cool the aqueous solution to room temperature, then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide with a mass fraction of 2% to carry out 30min activation treatment, The reaction pH was maintained at 4 to 5, and then 1.2% ε-polylysine was added to react for 10 hours. After the reaction was completed, the product was dialyzed for 12 hours with pure water as the dialysis medium, and the product after dialysis was freeze-dried. The modified carboxymethyl cellulose freeze-dried powder was obtained.

[0050] (2) Preparation of nasal cavity filling material B: dissolve polylysine-modified carboxymethylcel...

Embodiment 3

[0051] Embodiment 3, preparation of nasal cavity filling material C

[0052] (1) Modification of carboxymethyl cellulose: Add 3.0 g of sodium carboxymethyl cellulose (average molecular weight 250,000 Daltons, degree of substitution 0.9) into 100 mL of purified water, fully stir and dissolve in a water bath at 60°C, Obtain the aqueous solution of carboxymethylcellulose sodium and make this aqueous solution cool to room temperature, then add the 1-(3-dimethylaminopropyl group)-3-ethylcarbodiimide that mass fraction is 2.5% to carry out 30min activation treatment, The reaction pH was maintained at 4 to 5, and then 1.5% ε-polylysine was added to react for 12 hours. After the reaction was completed, the dialysis treatment was carried out with pure water as the dialysis medium for 24 hours, and the dialysis product was freeze-dried to obtain improved Freeze-dried powder of carboxymethylcellulose.

[0053] (2) Preparation of nasal filling material C: dissolve polylysine-modified c...

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Abstract

The present invention provides a nasal cavity filling material, which comprises: a hydrophilic polymer matrix and polylysine-modified carboxymethyl cellulose in fiber form dispersed in the hydrophilic polymer matrix, wherein In the nasal cavity filling material, the weight percentage of the polylysine-modified carboxymethyl cellulose in fiber form is 10% to 40%. The nasal cavity filling material provided by the present invention has high bending resistance and compression resistance, good biosafety and biocompatibility and remarkable antibacterial performance; in addition, it also has high water absorption ratio and water absorption volume expansion magnification and faster in vivo degradability.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a high-expansion degradable nasal cavity filling material composed of non-animal-sourced natural polymer materials and a preparation method thereof. Background technique [0002] In recent years, with the intensification of environmental pollution and the deterioration of air conditions, diseases such as rhinitis, sinusitis, and nasal polyps have plagued more and more people. Therefore, nasal cavity surgery has become the most common surgical operation in China and even in the world. Nasal cavity surgery is prone to bleeding due to the rich local blood vessels, deep wounds and inability to suture to stop bleeding after surgery. Therefore, the success of nasal endoscopic surgery and postoperative recovery are closely related to nasal cavity filling materials. [0003] There are various kinds of nasal cavity filling materials currently used, with different effects. Among them, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/0036A61L24/0042A61L24/08A61L2400/04C08L1/286
Inventor 余建均张小燕顾金花胡慧李雅楠
Owner 诺一迈尔(山东)医学科技有限公司