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Use of mulberry extract in preparation of medicine for treating abnormal glycolipid metabolism in mammals

A technology for mammalian and glycolipid metabolism, which is applied in the field of use of mulberry extract in the preparation of medicines for treating abnormal glucose and lipid metabolism in mammals, and can solve the problem of rarely reported drug effects, inability to reflect the role of genetic factors, and model individuals. problems such as large differences, to achieve good therapeutic effects, small individual differences, and high safety effects

Pending Publication Date: 2020-09-15
BEIJING WEHAND BIO PHARMA CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although there have been a variety of research reports on natural drugs for lowering blood sugar and lipids, there are few reports on the efficacy of reducing glycosylated hemoglobin and blood lipid indicators at the same time. At present, it is still necessary to continue research and development of safer and more effective drugs to prevent and treat type 2 diabetes and related complications such as abnormal lipid metabolism
In addition, since the main pathogenesis of type 2 diabetes is insulin resistance or insufficient insulin secretion in pancreatic tissue, many studies have used a high-sugar and high-fat diet combined with STZ injection to prepare animal models of type 2 diabetes for related experiments, which cannot reflect the role of genetic factors, and Modeling individual differences are large, therefore, the research results may have a certain deviation from the actual situation of human patients

Method used

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  • Use of mulberry extract in preparation of medicine for treating abnormal glycolipid metabolism in mammals
  • Use of mulberry extract in preparation of medicine for treating abnormal glycolipid metabolism in mammals

Examples

Experimental program
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Effect test

preparation example 1

[0027]Take 1000kg of fresh mulberry branches (Yuesang No. 11), crush them, add 4000L of water, extract by heating and reflux for 2 hours, combine the extracts, filter to remove insoluble matter, and obtain a crude extract. The crude extract was thermally concentrated until the solid content reached 4%, and was used as the sample solution for the cationic resin column.

[0028] Use 150kg of D113 type macroporous weakly acidic styrene-acrylic cationic resin to pack the column, use 2mol / L hydrochloric acid solution to wash until the pH of the eluate is 4.5; use 1mol / L sodium hydroxide solution to wash until the pH of the eluate is 8.5; 2mol / L hydrochloric acid solution until the pH of the eluate is 4.5; then rinse with 5 times the column volume of deionized water to complete the activation. Load the concentrated extract, then use 1000L 2.5mol / L ammonia water to elute, the elution rate is 6BV / h, and collect the eluate when the pH of the cationic column effluent is >7, when the co...

preparation example 2

[0035] Take 10kg of fresh mulberry branches (Sangteyou No. 2), crush them, add 150L of water, add in 2 times, extract by decoction for 3 hours each time, combine the extracts, and filter to remove insoluble matter. The extract was thermally concentrated until the solid content reached 8%, and it was transferred to an alcohol precipitation tank, and 2367.9 g of absolute ethanol (3 L) was added under a stirring blade of 300 rpm. After the ethanol was added, the stirring was stopped, and the alcohol was precipitated for 24 hours, and the supernatant was taken as the sample solution for the cationic resin column. Use 002SC type strongly acidic styrenic cationic resin 5kg packing column, according to the method for embodiment 3 Cationic resin is activated. Load the extract that has been concentrated and alcohol-precipitated, and then use 100L5mol / L potassium chloride to elute at a rate of 5BV / h. Use 20% silicotungstic acid to detect the effluent, and start collecting when white pre...

preparation example 3

[0043] Take 100g of fresh mulberry (white mulberry), crush it, add 300ml of alcoholic water, add in 2 times, heat and reflux each time to extract

[0044] After 1 h, the extracts were combined, and the insoluble matter was removed by filtration to obtain a crude extract. The crude extract was concentrated by heat until the solid content reached 2%, and kept at 25°C as the sample solution for the cationic resin column.

[0045] Use 5g of 732 type strongly acidic styrene-based cationic resins to pack the column, and use 2.5mol / L hydrochloric acid solution to wash until washing

[0046] The pH of the effluent is 3.5; wash with 1.5mol / L sodium hydroxide solution until the pH of the eluate is 8.0; wash with 2.5mol / L hydrochloric acid solution until the pH of the eluate is 3.5; then use 3 times the column volume of deionized water Rinse to complete activation. Load the concentrated extract, then use 3L 0.1mol / L ammonia water to elute, the elution rate is 10BV / h, and collect the el...

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Abstract

The invention relates to use of a mulberry extract in preparation of a medicine for treating abnormal glycolipid metabolism and diseases caused by abnormal glycolipid metabolism in mammals, which is characterized in that the plant extract is prepared according to the following steps of: (1), preparing crude extract; (2), separating by cationic resin and / or optional anionic resin; (3), performing alcohol precipitation treatment on the resin effluent in the step (2); and, an optional step (4), performing concentration and drying. The mulberry extract in the invention can obviously reduce the glycosylated hemoglobin and the blood fat concentration of the type 2 diabetes KK-Ay mouse; simultaneously, the safety is high; and the good treatment effect is provided for the type 2 diabetes and the related complications, such as dyslipidemia.

Description

technical field [0001] The invention relates to the application of mulberry extract in the preparation of medicines for treating abnormal glucose and lipid metabolism in mammals and the diseases caused by them. Background technique [0002] Diabetes is a metabolic disease caused by multiple etiologies and characterized by persistent hyperglycemia. Long-term hyperglycemia may cause long-term damage to various tissues and organs (such as eyes, kidneys, heart, blood vessels, nerves, etc.), Insufficiency or failure. According to reports, in 2017, about 425 million adults worldwide suffered from diabetes, an average of 1 in every 11 people. Among them, the number of patients in China reached 114 million, making it the largest country in the world with diabetes patients. According to different pathogenesis, diabetes can be divided into type 1 diabetes, type 2 diabetes, gestational diabetes and other types of diabetes. Among them, type 2 diabetes is the main type of diabetes, acc...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K45/06A61P3/10A61P3/04A61P3/06A61P1/16A61P19/06A61P13/12A61P17/02A61P27/02A61P9/10A61P7/04A61P25/00A61P9/12A61P9/00
CPCA61K36/605A61K45/06A61P1/16A61P3/04A61P3/06A61P3/10A61P7/04A61P9/00A61P9/10A61P9/12A61P13/12A61P17/02A61P19/06A61P25/00A61P27/02A61K2300/00
Inventor 刘玉玲申竹芳金毅群刘率男刘志华朱向阳刘泉李彩娜
Owner BEIJING WEHAND BIO PHARMA CO LTD
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