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Antibacterial collagen film and preparation method thereof

A technology of antibacterial glue and collagen film, applied in the field of medical materials, can solve problems such as bacterial drug resistance

Active Publication Date: 2022-04-01
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current antibacterial collagen film mainly uses antibiotics as antibacterial components, which can easily lead to bacterial drug resistance.

Method used

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  • Antibacterial collagen film and preparation method thereof
  • Antibacterial collagen film and preparation method thereof
  • Antibacterial collagen film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0058] The preparation method of the above-mentioned antibacterial collagen film is simple and convenient, and the antibacterial collagen film prepared according to the above-mentioned preparation method of the antibacterial collagen film has stronger antibacterial ability than the existing collagen film with antibiotics as antibacterial components, and is not easy to produce drug resistance .

[0059] Such as figure 1 As shown, an embodiment of the present invention also provides an antibacterial collagen film 20, the antibacterial collagen film 20 includes a collagen layer 210 and an antibacterial layer 220 positioned on the collagen layer 210, the collagen layer 210 is a collagen film, and the antibacterial layer 220 includes a carrier 221 and nanosilver 222. The carrier 221 is at least one selected from chitosan, carboxymethyl chitosan, alkyl chitosan, oxidized chitosan and chitosan quaternary ammonium salt.

[0060] In the illustrated embodiment, the antibacterial layer...

Embodiment 1

[0070] (1) Animal membrane pretreatment: select bovine pericardium as the base material, remove excess fat tissue and accessory tissues by mechanical means, and wash with purified water several times, then cut the bovine pericardium into a uniform size (6cm×6cm ).

[0071] (2) Degreasing treatment: press bovine pericardium and ether by 5cm 2 The solid-liquid ratio was degreased, room temperature, 120rpm oscillation for 12h, ether was replaced, continued oscillation for 12h, and then dried to obtain degreased bovine pericardium.

[0072] (3) virus inactivation: the bovine pericardium after the degreasing of step (2) and 3wt% hydrogen peroxide solution are separated according to 5cm 2 / mL ratio of solid to liquid for virus inactivation, room temperature, 120rpm shaking for 2h, and then washed several times with water for injection to obtain the bovine pericardium after virus inactivation.

[0073] (4) decellularization treatment: the bovine pericardium after the virus inactiva...

Embodiment 2

[0077] (1) Pretreatment of animal membranes: bovine peritoneum was selected as the base material, excess fat tissue and accessory tissues were removed mechanically, and after washing with purified water several times, the bovine peritoneum was cut into a uniform size (8cm×10cm).

[0078] (2) Degreasing treatment: press the bovine peritoneum and chloroform by 6cm 2 / mL of solid-liquid ratio for degreasing treatment, room temperature, 150rpm vibration 24h, replace chloroform, continue shaking for 12h, and then dry to obtain degreased bovine peritoneum.

[0079] (3) virus inactivation: the bovine peritoneum after the degreasing of step (2) and 2wt% hydrogen peroxide solution are separated by 4cm 2 / mL ratio of solid to liquid for virus inactivation, room temperature, 150rpm shaking for 2h, and then using water for injection to wash several times to obtain the bovine peritoneum after virus inactivation.

[0080] (4) decellularization treatment: the bovine peritoneum after the vir...

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Abstract

The invention relates to an antibacterial collagen film and a preparation method thereof. The antibacterial collagen film includes a collagen layer and an antibacterial layer positioned on the collagen layer, the collagen layer is a collagen film, the antibacterial layer includes a carrier and nano silver, and the carrier is selected from chitosan, carboxymethyl chitosan, alkyl chitosan, At least one of oxidized chitosan and chitosan quaternary ammonium salt. The above-mentioned antibacterial collagen film is not easy to produce drug resistance and has long-lasting antibacterial properties.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an antibacterial collagen film and a preparation method thereof. Background technique [0002] Bone defects caused by trauma, infection, tumors, etc. can be filled with bone graft materials to replace part of the bone and increase bone mass. However, due to the different crawling speeds of cells in different bone tissue defect sites, the crawling and migration speed of cells with osteogenic potential is slower than that of fibroblasts and endothelial cells, and it is difficult to fill only bone defect sites with bone graft materials. Complete the repair of bone defects. Therefore, bone graft materials usually need to be combined with guided bone tissue regeneration (Guided bone regeneration, GBR), by covering the bone defect with a layer of biofilm as a physical barrier, selectively blocking epithelial and fibroblasts from entering the osteogenic space, At the same time, cells ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/58A61L27/50A61L27/24A61L27/30A61L27/34A61L27/54
CPCA61L27/58A61L27/50A61L27/24A61L27/306A61L27/34A61L27/54A61L2430/02A61L2400/12A61L2300/104A61L2300/232A61L2300/404A61L2300/602A61L2300/45A61L2430/40C08L5/08
Inventor 李丽花钟梅玲朱勇军康文亭佘振定谭荣伟
Owner SHENZHEN LANDO BIOMATERIALS