Preparation method of chitosan/sodium alginate dual-network hydrogel

A sodium alginate and chitosan technology, applied in biochemical equipment and methods, bone/connective tissue cells, cell culture support/coating, etc., can solve problems such as negative effects, and achieve low cytotoxicity and simple operation , Improve the effect of mechanical properties
CN111662464AActive Publication Date: 2020-09-15NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2020-09-15

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Abstract

The invention discloses a preparation method of chitosan / sodium alginate dual-network hydrogel, comprising the following steps of: carrying out a Schiff base reaction on a prepolymer solution composedof modified chitosan, modified sodium alginate, a photoinitiator and water to obtain single-network hydrogel; and reacting the single-network hydrogel under the irradiation of ultraviolet light to obtain secondary photo-crosslinked chitosan / sodium alginate double-network hydrogel, wherein the modified chitosan is carboxymethyl chitosan grafted with a collagen peptide; the modified sodium alginateis formylated sodium alginate modified by methacrylic acid. The collagen peptide disclosed by the invention has non-immunogenicity, and can be grafted on chitosan through an enzymatic reaction underthe condition of not using a toxic cross-linking agent, so that the cell compatibility and the cell proliferation promoting capability of the material are improved.
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Description

technical field

[0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a preparation method of a chitosan / sodium alginate double network hydrogel. Background technique

[0002] The skin is on the surface of the body, directly in contact with the external environment, and has functions such as protection, excretion, temperature regulation, and perception of external stimuli. It is the largest organ of the human body. However, a large area of ​​the skin is exposed, and it is extremely vulnerable to various injuries in daily life, such as mechanical trauma, burns, and chronic ulcers. Skin wound healing is a major clinical problem, and wound infection caused by bacteria during wound recovery is the most common complication, and severe cases can lead to death. Due to its natural porous structure and high water content, hydrogel can absorb a large amount of exudate, act as a barrier against bacteria, and also maintain a moist env...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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