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Ultrafine crystal Cu-Mg alloy intrauterine device

An intrauterine device and ultra-fine crystal technology, applied in medical science, surgery, etc., can solve problems such as uncontrollable release of copper ions, bleeding, pain and inflammation, burst release of copper ions, etc., achieve excellent contraceptive effect and reduce toxicity , the effect of controllable release rate

Inactive Publication Date: 2020-10-16
GUANGDONG GENERAL HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the traditional copper-containing IUD is inserted, there are problems such as the initial burst release of copper ions, the uncontrollable release of copper ions, and the aggravated mechanical stimulation of the uterus due to the deposition of corrosion products in the later stage, which may cause complications such as bleeding, pain, and inflammation. , which is the main drawback of current copper-containing IUDs

Method used

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  • Ultrafine crystal Cu-Mg alloy intrauterine device
  • Ultrafine crystal Cu-Mg alloy intrauterine device
  • Ultrafine crystal Cu-Mg alloy intrauterine device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] According to the composition and ratio of Cu-Mg alloy, weigh copper powder (≥99.9wt.%) and magnesium powder, or weigh Cu-Mg alloy containing magnesium, mix them evenly, and melt them in a vacuum melting furnace. At 1250°C, Cu-Mg alloy ingots of different compositions with regular grain size (>1 μm) were obtained after pouring. Cut the ingot into After annealing at 450°C for 2 hours, perform equal angular extrusion or continuous extrusion at room temperature, choose B C path, the extrusion speed is 10-20mm / s, and the extrusion is repeated 4 times or more to obtain an ultrafine-grained Cu-Mg alloy.

[0045] Table 1 shows typical Cu-Mg alloys and their processing paths, grain size and copper ion detonation release in SUF. figure 1 It is the typical microstructure of ultrafine-grained Cu-Mg alloy under TEM, figure 2 The long-term copper ion release behavior of typical ultrafine-grained Cu-Mg alloys in SUF is shown here. Only ultrafine-grained Cu-0.4Mg alloys are repres...

Embodiment 2

[0049] According to the method in Example 1, ultrafine-grained Cu-0.4Mg alloy (UFG Cu-0.4Mg), coarse-grained Cu (CGCu) and ultra-fine-grained Cu (UFG Cu) were prepared, and their effects on uterine cavity-related cells were evaluated. toxicity. After leaching in the cell culture medium for 24 hours, the release of copper ions in the three groups of materials is arranged from low to high as follows: UFG Cu-0.4Mg Figure 4 The toxicity of 10% concentration extract to uterine related cells (including human endometrial epithelial cells, human endometrial stromal cells, human umbilical vein endothelial cells and L929 cells) is given, wherein, negative is a negative control, positive as a positive control. It can be seen from the figure that the introduction of a small amount of magnesium significantly improves the cytocompatibility of UFG Cu-0.4Mg alloy and reduces the toxicity to uterus-related cells. In addition, UFG Cu-0.4Mg alloy did not cause the expression of inflammatory-rel...

Embodiment 3

[0051] According to the method described in Example 1, an ultra-fine-grained Cu-0.4Mg alloy (UFG Cu-0.4Mg) was obtained, and the size was obtained by wire electric discharge cutting or machining. The UFG Cu-0.4Mg alloy round rod, one end of the small round rod has a groove, and is tied with non-degradable sutures. The whole is used as an ultra-fine grain Cu-Mg alloy intrauterine device for animal experiments, and is used for unilateral uterine horn implantation. . Compared with the normal control group (NC, no contraception), the UFG Cu-0.4Mg alloy IUD implanted side, namely the right side (implantation side), had no embryo formation; meanwhile, the left side (non-implantation side) had intact Embryos were formed, and the shape and color were not different from those of the normal control group ( Figure 5 ), there was no significant difference in the weight change of the rats in the implantation group and the normal control group. As shown in Table 2, among 20 female rats,...

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Abstract

The invention discloses an ultrafine crystal Cu-Mg alloy intrauterine device. An ultrafine crystal Cu-Mg alloy is taken as a copper ion source; the ultrafine crystal Cu-Mg alloy contains 0-1wt.% of Mgand the balance of Cu, but the content of the Mg is greater than 0; and the average grain size of the ultrafine crystal Cu-Mg alloy is smaller than 1 micron. The ultrafine crystal Cu-Mg alloy is taken as the copper ion source, so that corrosion is uniform; burst release of copper ions in an initial implanting stage is avoided; the copper ions are controllable in release rate and are stably released for a long period of time; excessive corrosion products are not deposited; and the ultrafine crystal Cu-Mg alloy intrauterine device is excellent in contraceptive effect and low in risk of complications, such as hemorrhage, pain and inflammation.

Description

technical field [0001] The invention belongs to the field of female contraceptive devices, and in particular relates to an ultrafine-grained Cu-Mg alloy intrauterine device and a preparation method thereof. Background technique [0002] Intrauterine device (IUD) is a safe and effective long-acting contraceptive tool for women. About 60% of women of childbearing age in my country use IUD as a contraceptive measure. , economical and reversible. However, after the traditional copper-containing IUD is inserted, there are problems such as the initial burst release of copper ions, the uncontrollable release of copper ions, and the aggravated mechanical stimulation of the uterus due to the deposition of corrosion products in the later stage, which may cause complications such as bleeding, pain, and inflammation. , which is the main drawback of current copper-containing IUDs. Therefore, how to reduce the explosive release of copper ions in the early stage of copper-containing IUD i...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/16A61L31/14
CPCA61L31/022A61L31/14A61L31/16A61L2300/102A61L2300/40A61L2300/602
Inventor 郑玉峰贺斌樊倩倩边东
Owner GUANGDONG GENERAL HOSPITAL
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