Method for detecting glucose by electrochemical/colorimetric dual-mode sensor

A dual-mode, electrochemical technology, applied in electrochemical variables of materials, scientific instruments, material analysis by observing the effect on chemical indicators, etc., can solve the problems of inability to determine the glucose content in time, complexity

Inactive Publication Date: 2020-10-20
UNIV OF JINAN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In recent years, many techniques for detecting glucose have been developed, such as fluorescence, electrochemistry, etc., but most of them re

Method used

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  • Method for detecting glucose by electrochemical/colorimetric dual-mode sensor
  • Method for detecting glucose by electrochemical/colorimetric dual-mode sensor

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Embodiment 1

[0022] Example 1 (from human blood)

[0023] A method for detecting glucose with an electrochemical / colorimetric dual-mode sensor with simple operation, fast detection speed and low cost, comprising the following steps:

[0024] 1. Use Adobe Illustrator CS6 software to design the pattern on the computer and print it in batches on cut A4 size filter paper with a wax spray printer, and then heat it on a heating plate until the wax melts and penetrates the entire thickness of the paper to form a hydrophobic area, style as attached figure 2 As shown, 1 is a bioanode chip, and 2 is a biocathode chip.

[0025] 2. Print the carbon electrodes on the bioanode chip and the biocathode chip respectively by screen printing method.

[0026] 3. To functionalize the circular hydrophilic working area of ​​the bioanode, first, immerse it in sodium periodate solution (4wt%) for oxidation reaction, the reaction time is 0.5, 1, 2 and 3 h, the whole process requires Performed under dark conditio...

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Abstract

The invention discloses a method for detecting glucose by using a paper-based electrochemical/colorimetric dual-mode sensor. A hydrophobic region and a hydrophilic region are prepared on paper by utilizing wax printing and laser cutting technologies, and a carbon electrode is printed by virtue of a silk-screen printing technology. Different areas of the paper chip are functionalized through different methods, visual pre-judgment of glucose can be achieved through the color development effect of 3, 3 ', 5, 5'-tetramethyl benzidine, and a simple, convenient and rapid method is provided. A biofuel cell is constructed by utilizing the specific catalysis of glucose oxidase to glucose and the reduction effect of bilirubin oxidase to oxygen, and the open-circuit voltage is recorded by virtue of an electrochemical workstation, so that the ultra-sensitive detection of glucose is realized.

Description

technical field [0001] The invention relates to a method for detecting glucose by an electrochemical / colorimetric dual-mode sensor, belonging to the technical field of glucose detection. Background technique [0002] Diabetes is an incurable disease that is caused by insufficient insulin in the body, resulting in elevated blood sugar levels, called hyperglycemia, or reduced blood sugar concentrations, called hypoglycemia. Insulin is a hormone synthesized and secreted from the pancreas that mediates Induces a metabolic reaction involving glucose, during which it initiates the uptake of glucose by cell types in the body, thereby reducing the concentration of glucose in the blood. Diabetes is associated with many diseases, including celiac disease, cystic fibrosis, tuberculosis, and heart disease. These complications can lead to retinopathy leading to blindness, kidney disease leading to renal failure, peripheral nerve damage, and increase the risk of limb (foot) ulcer, amputat...

Claims

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Application Information

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IPC IPC(8): G01N27/416G01N27/327G01N27/30G01N21/78
CPCG01N27/416G01N27/3278G01N27/308G01N21/78
Inventor 刘悦于京华周晨曦
Owner UNIV OF JINAN
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