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Photoelectrochemical biosensor as well as preparation method and application thereof

A biosensor and photoelectrochemical technology, applied in the field of detection and analysis, can solve the problems of long time consumption and expensive use of instruments

Active Publication Date: 2020-10-27
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventors have found that these methods still have the disadvantages of using expensive instruments and time consumption

Method used

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  • Photoelectrochemical biosensor as well as preparation method and application thereof
  • Photoelectrochemical biosensor as well as preparation method and application thereof
  • Photoelectrochemical biosensor as well as preparation method and application thereof

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preparation example Construction

[0045] In yet another specific embodiment of the present invention, the preparation method of the above-mentioned photoelectrochemical biosensor is provided, and the preparation method includes:

[0046] S1. In situ preparation of a covalent organic polymer film on an electrode substrate;

[0047] S2, modifying palladium nanoparticles and aptamers onto the electrode substrate coated with a covalent organic polymer film.

[0048] In yet another specific embodiment of the present invention, the specific preparation method of step S1 includes:

[0049] Disperse 2,6-dihydroxynaphthalene-1,5-dicarbaldehyde (DHNDA) and tris(4-aminophenyl)amine (TAPA) into a solution containing xylene, absolute ethanol and glacial acetic acid, and disperse evenly to obtain The solutions are mixed, and the electrode substrate is immersed in the mixed solution.

[0050] The mass ratio of DHNDA and TAPA is 1:0.1~10, such as 1:0.1, 1:0.5, 1:1, 1:5 and 1:10;

[0051] The volume ratio of the xylene, abs...

Embodiment

[0075] The principle of this embodiment, such as figure 1 Shown:

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Abstract

The invention provides a photoelectrochemical biosensor as well as a preparation method and application thereof, and belongs to the technical field of detection and analysis. The photoelectrochemicalbiosensor comprises: an electrode, which comprises an electrode substrate and a covalent organic polymer film coating the electrode substrate, wherein the covalent organic polymer film is modified with palladium nanoparticles and an aptamer; and the covalent organic polymer film is prepared by carrying out a polymerization reaction on 2,6-dihydroxynaphthalene-1,5-diformaldehyde and tris(4-aminophenyl)amine. The cathode photoelectrochemical cell sensor is successfully constructed by in-situ synthesis of the covalent organic polymer film, can be used for detecting various cells such as cancer cells by changing the type of the aptamer, and has high sensitivity and strong specificity, so that the cathode photoelectrochemical cell sensor has a good practical application value.

Description

technical field [0001] The invention belongs to the technical field of detection and analysis, and in particular relates to a photoelectrochemical biosensor and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Photoelectrochemical biosensors have the advantages of simple instruments, high sensitivity, and easy miniaturization, and have been widely used in recent years. Among them, semiconductor nanomaterials are the most widely used photoactive materials. The quantum size effect of nanomaterials can split the energy level of materials into negative conduction band (CB) and positive valence band (VB), and the potential changes on the...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/30G01N33/543G01N33/569G01N33/574
CPCG01N27/3278G01N27/305G01N33/56966G01N33/57423G01N33/54346
Inventor 张春阳崔琳沈靖竺
Owner SHANDONG NORMAL UNIV
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