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Vitamin c-containing polycaprolactone microsphere filler and preparation method therefor

A technology of polycaprolactone and vitamins, applied in medical preparations containing active ingredients, skin care preparations, microcapsules, etc., can solve the problems of vitamin C instability and easy oxidation and decomposition

Active Publication Date: 2020-10-27
G2G生物公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem is that vitamin C is very unstable both in vivo and in vitro, reacts sensitively to external environments such as air (especially oxygen), heat or light, and is easily oxidatively decomposed

Method used

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  • Vitamin c-containing polycaprolactone microsphere filler and preparation method therefor
  • Vitamin c-containing polycaprolactone microsphere filler and preparation method therefor

Examples

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preparation example Construction

[0029]As a specific example of the preparation method of polycaprolactone microspheres containing vitamin C in the present disclosure, such a preparation method includes the following steps: (a) by dissolving polycaprolactone in the first solvent and dissolving vitamin C in a second solvent to prepare respective solutions, and then uniformly mix the two solutions to prepare a single solution to prepare a dispersed phase; (b) prepare an emulsion by mixing said dispersed phase with an aqueous solution (continuous phase) containing a surfactant (c) forming microspheres by extracting an organic solvent from the dispersed phase in said emulsion prepared in step (b) into a continuous phase and evaporating; and (d) said continuous phase from step (c) phase recovery of the microspheres to prepare vitamin C-containing polycaprolactone microspheres.

[0030] In step (a), the polycaprolactone preferably has an intrinsic viscosity in the range of 0.16 to 1.90 dL / g.

[0031] The first sol...

Embodiment 1

[0050] Example 1: Preparation of polycaprolactone microspheres encapsulated with ascorbic acid

[0051] By dissolving 4.9975 g of biocompatible polymer Purasorb PC 04 (manufacturer: Corbion, Netherlands) and 0.0025 g of ascorbic acid (manufacturer: Tokyo Chemical Industries, Japan) in 19.99 g of dichloromethane (manufacturer: JT Baker, USA) and 1.70 mL of dimethyl sulfoxide (manufacturer: Sigma Aldrich, USA), and then mix the two solutions to prepare a dispersed phase.

[0052] A 1 w / v% polyvinyl alcohol aqueous solution (viscosity: 4.8 to 5.8 mPa·s) was used as the continuous phase, and 1200 mL of the continuous phase was supplied to an emulsification device equipped with a 10 μm diameter porous membrane while injecting the prepared dispersion phase to prepare microspheres. The prepared microsphere suspension was placed in a preparation container and stirred at a speed of 150 rpm. The temperature of the membrane emulsification device and the preparation vessel was maintai...

Embodiment 1-1

[0054] Example 1-1: Preparation of polycaprolactone microspheres encapsulated with ascorbic acid

[0055] By dissolving 4.985 g of biocompatible polymer Purasorb PC 04 (manufacturer: Corbion, Netherlands) and 0.015 g of ascorbic acid (manufacturer: Tokyo Chemical Industries, Japan) in 19.94 g of dichloromethane (manufacturer: JT Baker, USA) and 1.70 mL of dimethyl sulfoxide (manufacturer: Sigma Aldrich, USA), and then mix the two solutions to prepare a dispersed phase.

[0056] A 1 w / v% polyvinyl alcohol aqueous solution (viscosity: 4.8 to 5.8 mPa·s) was used as the continuous phase, and 1200 mL of the continuous phase was supplied to an emulsification device equipped with a 10 μm diameter porous membrane while injecting the prepared dispersion phase to prepare microspheres. The prepared microsphere suspension was placed in a preparation container and stirred at a speed of 150 rpm. The temperature of the membrane emulsification device and the preparation vessel was maintai...

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Abstract

The present invention relates to a vitamin C-containing polycaprolactone microsphere, a filler comprising the same, and a preparation method therefor. Provided is a polycaprolactone microsphere fillerobtained by loading vitamin C into polycaprolactone microspheres, which, when injected into the body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent properties of restoring or expanding the bulk of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

Description

technical field [0001] Cross References to Related Applications [0002] This application claims the benefit of Korean Patent Application No. 10-2018-0003584 filed with the Korean Intellectual Property Office on January 10, 2018, the entire disclosure of which is incorporated herein by reference. [0003] The present disclosure relates to vitamin C-containing polycaprolactone microsphere filling and a preparation method thereof, more particularly, to such a vitamin C-containing polycaprolactone microsphere filling and a preparation method thereof, the filling not only The in vivo stability problem of vitamin C is solved by containing vitamin C therein, and when applied to a living body, exhibits rapid collagen regeneration and volume increase effects after treatment, and can also maintain the effects for a long time. Background technique [0004] A dermal filler is an injectable medical device that injects a material safe for the human body into the dermis of the face to r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/18
CPCA61L27/18A61L27/54A61L2430/34A61L2400/06A61L2300/622A61L2300/428C08L67/04A61K8/33A61Q19/08A61K8/025A61K8/676A61K2800/412A61K2800/91
Inventor 李羲龙薛恩永尹权赫罗勇河
Owner G2G生物公司
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