Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of method for controlling hydrogen sulfide content of acetylcysteine ​​solution

A technology of acetylcysteine ​​and hydrogen sulfide, which is applied in the field of controlling the content of hydrogen sulfide in acetylcysteine ​​solution, can solve the problems of decreased blood calcium, decreased calcium, low calcium and the like

Active Publication Date: 2022-07-26
HAINAN STAR PHARM CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The instructions of the imported and marketed samples clearly stated that the prescription contained disodium edetate and sodium hydroxide as excipients. However, disodium edetate can combine with calcium ions to form a soluble complex to cause a decrease in calcium. Edetate used in intravenous preparations Disodium acid can cause blood calcium to drop, which can lead to hypocalcemia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of method for controlling hydrogen sulfide content of acetylcysteine ​​solution
  • A kind of method for controlling hydrogen sulfide content of acetylcysteine ​​solution
  • A kind of method for controlling hydrogen sulfide content of acetylcysteine ​​solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0056] Example, preparation of acetylcysteine ​​solution for inhalation

[0057] (1) Acetylcysteine ​​solution for inhalation, the specification is: 3ml: 0.3g, the prescription composition of the unit dose product is shown in the following table:

[0058]

[0059] (2) This product does not come with special solvent.

[0060] (3) This product adopts brown neutral borosilicate glass ampoule as the inner packaging container, and the outer packaging chooses plastic tray and carton.

[0061] refer to figure 1 The process flow diagram shown and the cleanliness level required to prepare the acetylcysteine ​​solution for inhalation

[0062] 1) Clean the liquid distribution pipeline, the equipment used for liquid distribution, the liquid distribution pipeline is sterilized by steam on-line, and the equipment is sterilized by moist heat; the brown neutral borosilicate glass ampoule is washed with water for injection, and then dried and sterilized in a high-temperature tunnel oven a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for controlling the hydrogen sulfide content of an acetylcysteine ​​solution. The present invention adopts aseptic production technology to produce acetylcysteine ​​solution for inhalation, and compared with the sterilization production technology of imported drug Fulu Shi, it has better control effect on hydrogen sulfide. The content of hydrogen sulfide in cystine solution is not more than 100ppm. The acetylcysteine ​​solution for inhalation provided by the invention has reasonable prescription selection, safe and controllable production process and stable quality of the finished product.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for controlling the hydrogen sulfide content of an acetylcysteine ​​solution. Background technique [0002] Acetylcysteine, English name: Acetylcysteine, chemical name: N-acetyl-L-cysteine, molecular formula: C5H9NO3S, molecular weight: 163.20, structural formula: [0003] [0004] This product is white crystal or crystalline powder with a garlic-like odor and sour taste; easily soluble in water and ethanol, partially soluble in methanol; it has hygroscopicity. [0005] Acetylcysteine ​​was first used in the 1960s as a classic phlegm-relieving drug, but in the past ten years, with more and more extensive clinical use and continuous in-depth research, acetylcysteine ​​was discovered. Not only has the effect of mucolysis, but also has strong antioxidant effect and the effect of promoting the generation of pulmonary surfactant. Many clinical evidences have shown that acetylcyst...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K47/02A61K47/18A61K31/198A61P11/10A61P11/00A61P11/06
CPCA61K9/0073A61K47/02A61K47/183A61K31/198A61P11/10A61P11/00A61P11/06
Inventor 钟昌茂鲍瑞森符兴远符策裕
Owner HAINAN STAR PHARM CO LTD