Solid composition for preparing medical adhesive and medical adhesive prepared from solid composition

A solid composition and adhesive technology, applied in surgical adhesives, applications, medical science and other directions, can solve the problems of difficult transportation and storage, high transportation costs, poor stability of chemical substances, etc., and achieve a simplified purification method. , The effect of saving production cost and time, and low price

Inactive Publication Date: 2020-11-10
江苏德威兰医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the existing polymer hydrogel-based medical adhesives are all two liquid components. When necessary, the two liquid components are directly mixed, and the polymer hydrogel is formed after the gel is completed. However, this kind of polymer hydrogel is not easy to transport and store, the transportation cost is high, and the stability of the chemical substances in the solution state is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Add 2g of wheat starch into 30mL of an equal volume of purified water / absolute ethanol mixed solvent, then dissolve 1g of sodium periodate in 15mL of purified water and add to the mixed system for oxidation reaction. After reacting in the dark at room temperature for 12 hours, add ethylene glycol in an equimolar amount to sodium periodate to stop the reaction, filter with suction, wash the solid with purified water / ethanol mixed solvent repeatedly, and filter with absolute ethanol for the last time, 60 °C for 12 hours in vacuum to obtain aldylated wheat starch, the aldehyde content of which was measured to be 43.2%.

[0048] (2) Add 1g of aldylated wheat starch and 1g of gelatin to 30mL of absolute ethanol, mix and stir for 10min at room temperature, and filter with suction to obtain a solid powder, which is dried in vacuum at 40°C for 6h to obtain a solid for preparing a medical adhesive combination.

[0049] (3) Add 1.5 g of the above-mentioned solid composition ...

Embodiment 2

[0051] (1) Add 2g of sodium carboxymethyl starch into 15mL of an equal volume of purified water / absolute ethanol mixed solvent, then dissolve 0.8g of sodium periodate in 7.5mL of purified water and add to the mixed system for oxidation reaction. After reacting in the dark for 5 hours at room temperature, add ethylene glycol in an equimolar amount to sodium periodate to stop the reaction, filter with suction, wash the solid with purified water / ethanol mixed solvent repeatedly, and filter with absolute ethanol for the last time, 45 °C and vacuum dried for 18 hours to obtain formylated sodium carboxymethyl starch, the aldehyde content of which was measured to be 35.3%.

[0052] (2) Add 1g of aldylated sodium carboxymethyl starch and 0.7g of chitosan to 30mL of absolute ethanol, mix and stir for 7min at room temperature, and filter with suction to obtain a solid powder, which is vacuum-dried at 40°C for 6h to obtain Solid compositions for medical adhesives.

[0053] (3) Add 1.5 g...

Embodiment 3

[0055] (1) Add 2g of sodium carboxymethyl starch into 15mL of an equal volume of purified water / absolute ethanol mixed solvent, then dissolve 1.6g of sodium periodate in 7.5mL of purified water and add to the mixed system for oxidation reaction. After reacting in the dark at room temperature for 12 hours, add ethylene glycol in an equimolar amount to sodium periodate to stop the reaction, filter with suction, wash the solid with purified water / ethanol mixed solvent repeatedly, and filter with absolute ethanol for the last time, 45 °C and vacuum dried for 18 hours to obtain formylated sodium carboxymethyl starch, the aldehyde content of which was measured to be 73.6%.

[0056] (2) Add 1g of aldylated sodium carboxymethyl starch and 1g of chitosan to 30mL of absolute ethanol, mix and stir at room temperature for 7min, and filter with suction to obtain a solid powder, which is vacuum-dried at 40°C for 6h to obtain Solid composition of adhesive.

[0057] (3) Add 1.5 g of the abov...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a solid composition for preparing a medical adhesive and the medical adhesive prepared from the solidcomposition. Vegetable polysaccharide is selected, is modified with aldehyde groups through an oxidation reaction, and is further cross-linked with an amino-containing polymer material in the presenceof water or a buffer solution to prepare the medical adhesive. The used materials are widely applied to the fields of medical treatment, foods and the like, have good biocompatibility, can be degraded and metabolized in vivo, and are low in price and wide in source; and the formed hydrogel type medical adhesive of a three-dimensional network structure has good application potential in the aspectsof tissue adhesion, filling, sealing, hemostasis and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a solid composition for preparing medical adhesives and the prepared medical adhesives. Background technique [0002] In recent years, with the vigorous development of China's economy, the level of industrialization has increased year by year, and accidental injuries have also increased day by day. In addition to wars and natural disasters that will cause a large number of casualties, in daily work, injuries caused by traffic accidents, falls, machinery, sharp objects, falls, sprains and other factors are extremely common. [0003] Trauma generally refers to the damage caused by external mechanical action to any tissue of the human body (such as skin, muscle), which will cause the rupture and damage of organ structures, cells, blood vessels, biofilms, etc. All wounds, including surgical wounds, require immediate closure and repair to prevent infection and promote he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/0031A61L24/043A61L2400/04A61L2400/06
Inventor 杨飞李丹周啸田明明
Owner 江苏德威兰医疗器械股份有限公司
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