Preparation method of Sanjin micro-capsule preparation

A preparation and capsule material technology, which is applied in the preparation of Sanjin microcapsule preparations, can solve problems such as unacceptable by consumers, easy moisture deterioration of tablets, and influence on treatment effects, etc., to achieve improved encapsulation effect, stable properties, and prolonged storage period effect

Inactive Publication Date: 2020-11-13
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently commercially available Sanjin preparations are basically ordinary sugar-coated tablets or film-coated tablets. According to market sales, patient feedback, and the inspection of finished product samples, the tablets are easily affected by moisture and deteriorate during storage, thereby affecting the efficacy of the drug. , also directly affects the effect of treatment
Moreover, Sanjin Tablets have a relatively strong taste of traditional Chinese medicine, which some consumers cannot accept

Method used

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  • Preparation method of Sanjin micro-capsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of Sanjin microcapsule preparation, comprising the steps of:

[0029] (1) Put golden cherry root, smilax, yangkaikou, jinshateng and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add water 6 times the weight of the medicinal materials and decoct 3 times, Decoct for 2 hours each time, filter, combine the filtrates, and concentrate at a pressure of -0.06Mpa and a temperature of 75°C to a solid content of 55% to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 80°C and wind speed Dry at 15m / s to get Sanjin powder;

[0030] (2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water according to the mass ratio of 4:3:5:8:12 to form a solution with a mass fraction of 32%, heat and stir evenly , to obtain the cyst material liquid;

[0031] (3) Add Sanjin powder, plasticizer and capsule material liquid into a homogenizer, and perform homogenization tr...

Embodiment 2

[0034] A preparation method of Sanjin microcapsule preparation, comprising the steps of:

[0035] (1) Put golden cherry root, smilax, yangkaikou, jinshateng and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add water 7 times the weight of the medicinal materials and decoct twice, Decoct for 2.5 hours each time, filter, combine the filtrates, and concentrate at a pressure of -0.08Mpa and a temperature of 65°C to a solid content of 50% to obtain Sanjin extract, which is then passed through a pulse air dryer at a temperature of 100°C. Dry at a wind speed of 15m / s to obtain Sanjin powder;

[0036] (2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water at a mass ratio of 3:2:4:7:15 to form a solution with a mass fraction of 28%, heat and stir evenly , to obtain the cyst material liquid;

[0037] (3) Add Sanjin powder, plasticizer and capsule material liquid into the homogenizer, and perform homogenization treatm...

Embodiment 3

[0040] A preparation method of Sanjin microcapsule preparation, comprising the steps of:

[0041] (1) Put golden cherry root, smilax, yangkaikou, jinshateng and centella asiatica in the extraction tank according to the weight ratio of 10:5:5:3:3, add water 5 times the weight of the medicinal materials and decoct 3 times, Decoct for 2 hours each time, filter, combine the filtrates, and concentrate at a pressure of -0.08Mpa and a temperature of 70°C to a solid content of 50% to obtain Sanjin extract, and then pass through a pulse air dryer at a temperature of 90°C and a wind speed of Dry at 12m / s to get Sanjin powder;

[0042] (2) Add tea saponin, rhamnolipid, konjac gum, carrageenan and gum arabic into water at a mass ratio of 5:2:3:8:12 to form a solution with a mass fraction of 28%, heat and stir evenly , to obtain the cyst material liquid;

[0043] (3) Add Sanjin powder, plasticizer and capsule material liquid into the homogenizer, and perform homogenization treatment at a...

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Abstract

The invention discloses a preparation method of a Sanjin micro-capsule preparation, comprising the following steps of: putting cherokee rose root, chinaroot greenbrier, radix akebiae, Japanese climbing fern stem and centella asiatica into an extraction tank according to a mass ratio of 10: 5: 5: 3: 3, adding water, decocting, filtering, combining filtrates, concentrating to obtain a Sanjin extract, and drying by using a pulsed airflow dryer to obtain Sanjin powder; adding tea saponin, rhamnolipid, konjac glucomannan, carrageenan and Arabic gum into water according to a mass ratio of (3-5): (1-3): (3-5): (5-10): (10-20), and heating and uniformly stirring to obtain a capsule wall material liquid; adding the Sanjin powder and a plasticizer into the capsule wall material liquid, adding the capsule wall material liquid into a homogenizer, and homogenizing according to a mass ratio of the Sanjin powder to the plasticizer of (2-3): 1 to obtain an emulsified liquid; and adding into a spray fluidized bed for drying and granulating to obtain the Sanjin micro-capsule particles. The Sanjin micro-capsule preparation provided by the invention not only can effectively realize efficient encapsulation of drugs, improve the stability of the drugs and prolong the storage period, but also can cover up the unpleasant odor of the Sanjin drugs, so that the Sanjin micro-capsule preparation is more easily accepted by patients.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparations, in particular to a preparation method of Sanjin microcapsule preparations. Background technique [0002] Sanjin preparation is a traditional Chinese medicine preparation made by extracting and processing five flavors of traditional Chinese medicines such as Rosa chinensis root, King Kong thorn (Sarsaparilla), Jinsha rattan, Yangkaikou, and Centella asiatica. It has been sold in the market. Its pharmacological effects are: antibacterial, anti-inflammatory , swelling, clearing away heat, diuretic, analgesic, anti-oxidative free radicals, improving immunity, etc. Function cures mainly: heat-clearing and toxic substances removing, promoting dampness and treating stranguria, benefiting the kidney. It is used for damp-heat in lower Jiao, hot stranguria, short red urination, astringent and painful stranguria; acute and chronic pyelonephritis, cystitis, and urinary tract inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61P13/00A61P13/10A61P13/12A61K9/52A61K47/36A61K47/14A61K47/24A61K47/26A61K47/28
CPCA61K9/5015A61K9/5036A61K9/5089A61K36/12A61K36/185A61K36/23A61K36/738A61K36/896A61K36/90A61P13/00A61P13/10A61P13/12A61K2300/00
Inventor 黄锁义雷智冬李童黄与路
Owner 右江民族医学院
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