Compound amino acid enteric capsules for dogs and preparation method thereof

A compound amino acid, enteric-coated capsule technology, applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of stomach irritation, large side effects, adverse reactions, etc., and achieve extended shelf life, simple operation, The effect of reducing adverse effects

Inactive Publication Date: 2020-11-20
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if amino acid drugs disintegrate in the stomach, the side effects on dogs are relatively large, especially for weak and sick dogs, which are likely to stimulate their stomachs and cause adverse reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0031] Embodiments 1-6 A kind of compound amino acid enteric-coated capsule for dogs

[0032] Examples 1 to 6 respectively provide a compound amino acid enteric-coated capsule for dogs, and the raw materials for making the active ingredients are shown in Table 1.

[0033] Table 1 Raw materials of compound amino acid enteric-coated capsules for dogs in Examples 1-6

[0034] .

[0035] In actual operation, the lubricant is magnesium stearate, talcum powder, or one or both of them can be mixed in any ratio, and the diluent is one or two of starch and microcrystalline cellulose, and both can be mixed in any ratio. , Embodiments 1 to 6 are representative examples.

Embodiment 7

[0036] Example 7 A preparation method of compound amino acid enteric-coated capsules for dogs

[0037] This embodiment is used to prepare Examples 1-6, and the preparation method is carried out according to the following steps:

[0038] S1, mixing

[0039] This step is performed in the following order,

[0040] S11. Weigh each raw material according to the weight of each raw material shown in Examples 1 to 6;

[0041] S12, passing lysine hydrochloride, methionine, tryptophan, leucine, isoleucine, valine, phenylalanine, histidine hydrochloride, arginine hydrochloride, threonine respectively 100-mesh sieve, pass diluent and lubricant through 80-mesh sieve respectively;

[0042] S13. Lysine hydrochloride, methionine, tryptophan, leucine, isoleucine, valine, phenylalanine, histidine hydrochloride, arginine hydrochloride, threonine and diluted The agent is mixed uniformly to obtain material A;

[0043] S2, granulation

[0044] This step is performed in the following order,

...

Embodiment 8

[0051] Example 8 Quality inspection of compound amino acid enteric-coated capsules for dogs

[0052] The quality of the compound amino acid enteric-coated capsules for dogs prepared according to the preparation method provided in Example 7 using the formulations of Examples 1-6 was inspected with reference to the method specified in the product quality standard, and the test results are shown in Table 2.

[0053] Table 2 Quality inspection results of compound amino acid enteric-coated capsules for dogs in Examples 1-6

[0054] .

[0055] It can be seen from the above table that the test results of the compound amino acid enteric-coated capsules for dogs prepared according to the formulas of Examples 1-6 all meet the product quality standards, and the amino acid content can meet the nutritional needs of dogs for amino acids. The test results of the disintegration time limit show that the enteric-coated capsules prepared according to the preparation method of Example 7 do not...

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PUM

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Abstract

The invention discloses compound amino acid enteric capsules for dogs. In terms of 250 parts by weight, the compound amino acid enteric capsules for dogs are prepared from the following raw materials:5-7 parts of lysine hydrochloride, 1-4 parts of methionine, 0.5-2 parts of tryptophan, 6-9 parts of leucine, 2-5 parts of isoleucine, 1-4 parts of valine, 4-7 parts of phenylalanine, 3-6 parts of histidine hydrochloride, 4-7 parts of arginine hydrochloride, 2-5 parts of threonine, 2-5 parts of a lubricant and the balance of a diluent. According to the compound amino acid enteric capsules for dogs, adverse reactions caused by stimulation to the stomach are reduced, the adverse effect of the medicine on the appetite of dogs is reduced, the requirement of dogs for amino acid in vivo is met, thestability and good appearance of effective components of the medicine are guaranteed, the shelf life of the medicine is prolonged, and the preparation method is simple to operate. The invention belongs to the technical field of veterinary drugs, and is suitable for preparing the compound amino acid enteric capsules for dogs.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a veterinary drug, in particular to a compound amino acid enteric-coated capsule for dogs and a preparation method thereof. Background technique [0002] Now more and more families choose to domesticate dogs as pets, but some dogs are weak and sick. Generally, they often show symptoms such as decreased appetite, reduced food intake, and physical weakness. After the above symptoms appear, the nutrients in the dog body will be lost With the prolongation of time, it will be lost in a large amount. If the above symptoms are not improved in time, it will lead to slow growth or even death of the dog. [0003] At present, the supplements used to enhance the dog's physical fitness are mainly glucose and sodium chloride injections. The injections mainly supplement water and energy, and regulate the balance of electrolytes in the body, but they cannot improve the nutritio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61K9/48A61P3/02A61K31/405A61K31/198A61K9/16
CPCA61K31/198A61K31/405A61K31/4172A61K9/4858A61K9/485A61P3/02A61K9/1652A61K2300/00
Inventor 裴有志陈淑芳李凤英王成彬
Owner HEBEI KEXING PHARMA
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