A kind of preparation method of terbutaline

A technology of terbutaline and chemical equation, applied in the field of preparation of terbutaline, can solve the problems such as that the antioxidant problem cannot be well solved, will not be significantly improved, and the purity of terbutaline is low. , to reduce environmental pressure, reduce polarity, and achieve the effect of high purity

Active Publication Date: 2022-05-13
南京恒道医药科技股份有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the reported process, due to the good water solubility of terbutaline sulfate and its own easy oxidation, the post-treatment is relatively cumbersome. At present, after the solvent is evaporated to dryness, the terbutaline sulfate is refluxed with methanol to cool down and crystallize. High temperature conditions are very likely to cause terbutaline Oxidation of butaline, resulting in lower purity of terbutaline
If the antioxidant problem is not well resolved, the quality of the final product of terbutaline will not be significantly improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of terbutaline

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: a kind of preparation method of terbutaline

[0032] Including the following steps:

[0033] S1. Add 10 kg of compound I (65.72 mol) and 30 L of dichloromethane into the reactor, stir and dissolve, add 8.55 kg of propionic anhydride (65.72 mol), control the reaction temperature and stir at 10°C for 10 h;

[0034] S2. After the reaction is completed, add 10% diisopropylethylamine aqueous solution to the system, stir and wash thoroughly, collect the dichloromethane phase, and distill under reduced pressure to obtain 18.44 kg of yellow oil compound II (96% yield);

[0035] S3. Add 18.44kg compound II (63.08mol) and 35L ethyl acetate, 4.61kg tert-butylamine (63.08mol), 2.52kg sodium hydroxide (63.08mol) and sodium thiosulfate (63.08mol) in the reactor, control reaction The temperature was stirred and reacted at 10°C for 8h;

[0036] S4. After the reaction is completed, add purified water to the system to wash the reaction solution, collect the ethyl acetate ...

Embodiment 2

[0039] Embodiment 2: a kind of preparation method of terbutaline

[0040] Including the following steps:

[0041] S1. Add 10kg of compound I (65.72mol) and 30L of dichloromethane into the reactor, stir and dissolve, add 51.98kg of butyric anhydride (65.72mol), control the reaction temperature at 25°C and stir for 6h;

[0042] S2. After the reaction is completed, add 20% 1-methylpiperidine aqueous solution to the system, stir and wash thoroughly, collect the dichloromethane phase, and distill under reduced pressure to obtain 18.64 kg of yellow oil compound II (97% yield);

[0043] S3. Add 18.64kg compound II (63.76mol) and 35L ethyl acetate, 46.64kg tert-butylamine (637.6mol), 7.65kg sodium hydroxide (191.28mol) and antioxidant BHT (255.04mol) in the reactor to control the reaction Stir the reaction at 40°C for 4.5h;

[0044] S4. After the reaction is completed, add purified water to the system to wash the reaction solution, collect the ethyl acetate phase, and distill under re...

Embodiment 3

[0045] Embodiment 3: a kind of preparation method of terbutaline

[0046] S1. Add 10kg of compound I (65.72mol) and 30L of dichloromethane into the reactor, stir and dissolve, add 122.40kg of valeric anhydride (657.2mol), control the reaction temperature at 40°C and stir for 1h;

[0047] S2. After the reaction is completed, add 30% 4-methylmorpholine aqueous solution to the system, stir and wash thoroughly, collect the dichloromethane phase, and distill under reduced pressure to obtain 17.67kg (yield 92%) of yellow oil compound II;

[0048] S3. Add 17.67kg compound II (60.46mol) and 35L ethyl acetate, 88.44kg tert-butylamine (1209.25mol), 12.09kg sodium hydroxide (302.3mol) and antioxidant BHA (483.68mol) in the reactor to control the reaction Stir the reaction at 70°C for 1 h;

[0049] S4. After the reaction, add purified water to the system to wash the reaction solution, collect the ethyl acetate phase, and distill under reduced pressure to obtain 12.40 kg of terbutaline fi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmacy, and in particular relates to a preparation method of terbutaline. The technical points are as follows: a method for preparing terbutaline, S1. Add compound I and methylene chloride into the reaction kettle, stir and dissolve and then add acid anhydride; S2. After the reaction is completed, add dilute alkaline water into the system to fully stir and wash , collect the dichloromethane phase, and distill under reduced pressure to obtain a yellow oily substance, which is compound II; S3. add compound II, ethyl acetate, tert-butylamine, sodium hydroxide and oxidation protection agent to the reaction kettle; S4. step S3 completes the reaction Then add purified water to the system to wash the reaction solution in step S3, collect the ethyl acetate phase, and distill the ethyl acetate phase under reduced pressure to obtain terbutaline. The technical solution provided by the invention reduces the difficulty of post-reaction treatment, makes the intermediate compound easy to separate from the reaction system, avoids the occurrence of side reactions such as epoxy bond hydrolysis, and increases the stability and stability of the final product terbutaline. yield.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of terbutaline. Background technique [0002] Terbutaline is a short-acting β2-receptor agonist COPD drug developed by AstraZeneca, and it is a clinically recommended drug for patients with mild and moderate COPD. Compared with other marketed short-acting β2-receptor agonist terbutaline sulfate inhalation, it has lower dose-dependent side effects. Terbutaline first used 3,5-dibenzyloxyacetophenone as the starting raw material to obtain 2-(N-benzyl tert-butylamino)-1-(3,5-dibenzyl Oxyphenyl) ethanone sulfate. After debenzylation by hydrogenation reduction, terbutaline was prepared, dissolved in water, adjusted to pH 5.5 with alkali, evaporated to dryness, and purified by crystallization of a large amount of methanol. Acid-base adjustment and pH control to control the sulfate content lead to the introduction of a large amount of salt, and the solubility o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07C213/04C07C213/00C07C213/10C07C215/30C07D301/00C07D303/16
CPCC07C213/04C07C213/00C07C213/10C07D301/00C07D303/16C07C215/30
Inventor 陶义华穆加兵黄迎春凌岫泉
Owner 南京恒道医药科技股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap