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Solid nano-powder composition containing nanoscale cannabidiol and preparation method and application of composition

A cannabidiol and composition technology, applied in the field of solid nano-powder compositions, can solve the problems of increasing the concentration of nano-suspension, difficult to obtain cannabidiol nano-crystals, small hydrophobic wetting coefficient, etc. Stability, precise and controllable nanoparticle size, and the effect of improving bioavailability

Active Publication Date: 2020-11-27
YUNNAN HEMPMON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cohesive energy of cannabidiol is small, and its hydrophobicity is strong and the wettability coefficient is small (k<0.05). Therefore, when it is made into nanocrystals, the stability of cannabidiol is poor, agglomeration will occur, and it is difficult to redissolve. Or the particle size is easy to increase
In particular, many unstable factors will be generated during the solidification of nanocrystals, including increasing the concentration of nanosuspensions, enhancing the interaction between them, causing them to aggregate or fuse, resulting in poor redispersibility after reconstitution
[0010] It is difficult to obtain stable cannabidiol nanocrystals in the prior art, so it is also difficult to obtain a composition containing nano-cannabidiol, which is used to prepare preparations containing nano-cannabidiol, such as pharmaceutical preparations, so as to achieve enhanced cannabidiol Purpose of using effects such as bioavailability of cannabidiol

Method used

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  • Solid nano-powder composition containing nanoscale cannabidiol and preparation method and application of composition
  • Solid nano-powder composition containing nanoscale cannabidiol and preparation method and application of composition
  • Solid nano-powder composition containing nanoscale cannabidiol and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Embodiment 1 A kind of preparation of cannabidiol nanocrystal (media grinding method)

[0139] Weigh 6.25g of poloxamer P188, 0.375g of povidone K30, 0.125g of tert-butyl hydroxyanisole and 0.125g of citric acid, mix them to obtain a stabilizer, put them in a 250mL grinding jar, add 50mL of purified water, and ultrasonically To disperse, add D 90 12.5g of cannabidiol raw material with a diameter of 7 μm was dispersed by ultrasonic waves, 100g of zirconia grinding beads (0.2mm in diameter) were added, and the grinding tank was installed in a low-temperature planetary ball mill (model: QM-KD2, manufacturer: Nanjing Nanda Instrument Co., Ltd.) , control the grinding temperature to 10°C, and grind for 6 hours at a speed of 500rpm. After the grinding is completed, the cannabidiol nanocrystal suspension is obtained by separation, and the suspension is placed in a low-temperature freezer at -40°C for 12 hours. Dry in a dryer for 12 hours at a cold trap temperature of -40°C an...

Embodiment 2

[0142] Embodiment 2 Preparation of a kind of cannabidiol nanocrystal (media grinding method)

[0143] Weigh the stabilizer containing 0.75g Cremphor RH40 (polyoxyethylene 40 hydrogenated castor oil), 0.125g microcrystalline cellulose and carmellose sodium copolymer (MCCS) and 0.0125g rosemary extract in a 250mL grinding jar Add 50mL of purified water, ultrasonically disperse, add D 902.5g of cannabidiol raw material with a diameter of 55 μm was dispersed by ultrasonic waves, 300g of zirconia grinding beads (0.5mm in diameter) were added, and the grinding tank was installed in a low-temperature planetary ball mill (model: QM-KD2, manufacturer: Nanjing Nanda Instrument Co., Ltd.) , control the grinding temperature to 10°C, and grind for 8 hours at a speed of 500rpm. After the grinding is completed, the cannabidiol nanocrystal suspension is obtained by separation. Dry in a dryer for 12 hours at a cold trap temperature of -40°C and a vacuum of 20 Pa to obtain solid nanocrystals o...

Embodiment 3

[0146] Example 3 Preparation of Cannabidiol Nanocrystals (High Pressure Homogenization Method)

[0147] Weigh the stabilizer containing 0.25g poloxamer P338, 0.02g hypromellose E4M and 0.03g tea polyphenols into a 250mL beaker, add 100mL purified water, ultrasonically disperse, add D 90 1g of cannabidiol raw material with a thickness of 7 μm was dispersed by ultrasonic waves, poured into the material cup of a high-pressure homogenizer (model: AH2010, manufacturer: ATS, Canada), and the homogenization temperature was controlled at 10°C. Cycle 5 times under 1000 bar pressure, and finally cycle 15 times under 1300 bar pressure to obtain cannabidiol nanocrystal suspension, freeze the suspension in a low-temperature freezer at -40°C for 12 hours, and place it in a freeze dryer. Dry for 18 hours under the conditions of cold trap temperature -40°C and vacuum degree of 20Pa to obtain cannabidiol solid nanocrystals.

[0148] Measure its average particle diameter and polydispersity ind...

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Abstract

The present technology relates to a cannabidiol nano powder, a composition containing the cannabidiol nano powder, a solution of the composition in an aqueous solvent, and application of the composition. The invention also relates to a preparation method of the cannabidiol nano powder. According to the composition containing cannabidiol nanocrystals, the dissolution rate of cannabidiol is improved, and the bioavailability of the cannabidiol in vivo is remarkably improved.

Description

technical field [0001] The invention relates to a stable solid nanopowder composition containing nanoscale cannabidiol, a stabilizer for the solid nanopowder composition, a preparation method and application thereof. Background technique [0002] Cannabidiol (CBD) is one of the cannabinoids with the molecular formula C 21 h 30 o 2 , is pale yellow, and is usually extracted from the natural plant cannabis. Cannabidiol is almost insoluble in water, but soluble in organic solvents such as ethanol, methanol, ether, benzene, chloroform and petroleum ether. [0003] The structural formula of cannabidiol is shown in the following formula I: [0004] [0005] Cannabidiol is the main chemical component of the medicinal plant cannabis. It has various pharmacological activities. It is extracted from the cannabis plant and is a non-addictive component in cannabis. It has anti-spasmodic, anti-anxiety, anti-inflammatory and other pharmacological effects. Cannabidiol can not only b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/05A61K47/10A61K47/32A61K47/12A61K47/44A61K47/38A61K47/46A61K47/36A61K47/14A61K47/22A61P1/06A61P25/22A61P29/00A61P21/02A61P25/00A61P25/24A61P25/28A61P25/16A61P37/02A61K8/86A61K8/92A61K8/81A61K8/73A61K8/34A61K8/37A61K8/02A61Q19/00
CPCA61K9/19A61K9/145A61K9/146A61K9/148A61K31/05A61K47/10A61K47/32A61K47/12A61K47/44A61K47/38A61K47/46A61K47/36A61K47/14A61K47/22A61P1/06A61P25/22A61P29/00A61P21/02A61P25/00A61P25/24A61P25/28A61P25/16A61P37/02A61K8/86A61K8/922A61K8/8176A61K8/731A61K8/73A61K8/347A61K8/37A61K8/022A61Q19/00A61K2800/413A61K2800/10
Inventor 代勇赵丽梅常坦然李如彦李庆中
Owner YUNNAN HEMPMON PHARMA CO LTD
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