Preparation method of acetylisovaleryl tylosin tartrate premix

A technology of tyvalomectin and tartaric acid, which is applied in the field of preparation of tyvanectin tartrate premix, and can solve the problems such as the bitter taste of tyvanectin tartrate

Inactive Publication Date: 2020-12-29
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This solution only reduces the production cost and improves the stability, but does not solve the bitter taste of tyvalosin tartrate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of preparation method of tyvalactin tartrate premix of the present embodiment comprises the following steps:

[0021] (1) Preparation of tyvalin tartrate suspension

[0022] Dissolve hydroxypropyl methylcellulose, propylene glycol, and xanthan gum in purified water, add tyvalactin tartrate crude drug and stir, and the percentages of the consumption of each raw material to the total weight of raw materials are: hydroxypropyl methylcellulose 42.5 %, 2.5% propylene glycol, 10% xanthan gum, 25% tylvalosin tartrate, 20% purified water, stirred and dissolved to obtain tyvalosin tartrate suspension.

[0023] (2) Centrifugal spray drying

[0024] Tivalamectin tartrate is centrifugally spray-dried in the screw pump spray tower, the inlet air temperature is set at 140°C, the outlet air temperature is 70°C, and the atomizer frequency is 30HZ. The material is collected by cyclone separation, and then passed through an 80-mesh sieve to obtain a tyvalin tartrate premix.

Embodiment 2

[0026] A kind of preparation method of tyvalactin tartrate premix of the present embodiment comprises the following steps:

[0027] (1) Preparation of tyvalin tartrate suspension

[0028] Dissolve polyacrylic resin Ⅳ, PVP-K30, and gum arabic in purified water, add tyvalectin tartrate raw material and stir, and the percentages of the amount of each raw material to the total weight of raw materials are: acrylic resin 12.5%, PVP-K30 0.5% , 2% gum arabic, 5% tyvalosin tartrate, 80% purified water, stir and dissolve to obtain tyvalosin tartrate suspension.

[0029] (2) Centrifugal spray drying

[0030] Tivalamectin tartrate is centrifugally spray-dried in the screw pump spray tower, the inlet air temperature is set at 180°C, the outlet air temperature is 90°C, and the atomizer frequency is 50HZ. The material is collected by cyclone separation, and then passed through an 80-mesh sieve to obtain a tyvalin tartrate premix.

Embodiment 3

[0032] A kind of preparation method of tyvalactin tartrate premix of the present embodiment comprises the following steps:

[0033] (1) Preparation of tyvalin tartrate suspension

[0034] Dissolve carboxymethylcellulose, propylene glycol, and gelatin in purified water, add tyvalactin tartrate crude drug and stir, and the consumption of each raw material accounts for the percentage of total raw material weight respectively: carboxymethylcellulose 30%, propylene glycol 2%, 5% gelatin, 20% tyvalomectin tartrate, and 43% purified water were stirred and dissolved to obtain a tilvalin tartrate suspension.

[0035] (2) Centrifugal spray drying

[0036] Tivalamectin tartrate is centrifugally spray-dried in the screw pump spray tower, the inlet air temperature is set at 160°C, the outlet air temperature is 80°C, and the atomizer frequency is 40HZ. The material is collected by cyclone separation, and then passed through an 80-mesh sieve to obtain a tyvalin tartrate premix.

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PUM

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Abstract

The invention discloses a preparation method of an acetylisovaleryl tylosin tartrate premix. The preparation method comprises the following steps of (1) preparing an acetylisovaleryl tylosin tartratesuspension: dissolving a coating agent, a stabilizer and a thickener in purified water, adding acetylisovaleryl tylosin tartrate, performing stirring, and dissolving to obtain the acetylisovaleryl tylosin tartrate suspension; and (2) centrifugal spray drying: carrying out centrifugal spray drying on the acetylisovaleryl tylosin tartrate suspension in a screw pump spray tower, collecting materialsthrough cyclone separation, and then sieving with an 80-mesh sieve to obtain an acetylisovaleryl tylosin tartrate premix. Compared with the prior art, the pungent smell of the flunixin meglumine crudedrug is masked, the palatability of the drug is changed, the treatment effect of the drug is improved, and the process is simple.

Description

technical field [0001] The invention relates to the technical field of veterinary pharmaceutical preparations, in particular to a preparation method of a tyvanectin tartrate premix. Background technique [0002] Tyvalin tartrate is the abbreviation of acetylisovaleryl tylosin tartrate, which is a new generation of macrolide antibiotics. Tyvalin tartrate has antibacterial activity against a variety of Gram-positive bacteria such as Staphylococcus, Micrococcus, Microbacterium, Bacillus, Corynebacterium, Aerobicella, Campylobacter, Enterococcus, Streptococcus, Arthrobacter, and Clostridium Bacteria, etc.; it also has good antibacterial activity against mycoplasma, and the effect is better at high concentrations; but it has no effect on most Gram-negative bacteria. In addition, tyvanectin tartrate has good therapeutic effects on Mycoplasma hyopneumoniae, Brachyspira hyodysenteriae and Lawsonia intracellulare. [0003] At present, there are two kinds of tyvanectin tartrate prep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7048A61K47/38A61K47/36A61K47/42A61P31/04
CPCA61K31/7048A61K9/146A61P31/04
Inventor 汪敦辉
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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