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Traditional Chinese medicine composition for protecting gastric mucosa as well as preparation method and application thereof

A composition and a technology for protecting the stomach, which are applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., can solve the problems of poor therapeutic effects, achieve improved protection, are suitable for large-scale production, and have simple preparation methods fast effect

Active Publication Date: 2021-01-15
生升美高科技(武汉)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common dosage forms of medicines are soft capsules. The active ingredients in ordinary soft capsules are taken orally and enter the stomach. After being digested by the stomach, all substances absorbed by the small intestine must enter the portal vein to the liver. After being processed by the liver, they are released to the whole body. Many nutrients are absorbed by the liver. Using post-transportation, the active ingredient is modified by the liver, and the concentration decreases, resulting in poor therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The optimization of embodiment 1 sesame oil and sea buckthorn seed oil mass ratio

[0035] The present embodiment mainly optimizes the mass ratio of sesame oil and sea buckthorn seed oil in the component to obtain the optimal total flavonoid extraction amount, as follows:

[0036] Take 50g of Pueraria lobata and 20g of Polygonatum chinensis, 100-mesh pulverization, add an appropriate amount of water to dissolve, and then add a mixture of sesame oil and sea buckthorn seed oil with a total mass of 400g. After mixing, heat to 120°C while stirring, then stop heating and continue stirring. By stirring, the active ingredients in Pueraria lobata and Polygonatum can be accelerated into the solvent to increase the extraction rate of active ingredients. Stop stirring when the temperature of the mixture drops to 100 ° C, and let stand overnight to fully extract, then the extract is subjected to vacuum distillation to remove the moisture in the mixture to obtain a concentrated solu...

Embodiment 2

[0043] This embodiment provides a traditional Chinese medicine composition for protecting gastric mucosa, comprising: 50g of pueraria, 20g of Polygonatum chinensis, 200g of sesame oil, 200g of sea buckthorn seed oil, 8g of Hericium erinaceus, 4g of chitosan oligosaccharide, and 6g of beeswax.

[0044] At the same time, a preparation method of the traditional Chinese medicine composition is also provided, specifically:

[0045] Step 1. Weigh a certain amount of Pueraria lobata and Polygonatum chinensis according to the formula, pulverize them to 100 meshes and mix them, add an appropriate amount of water to dissolve, and then add the sesame oil and sea buckthorn seed oil of the formula amount;

[0046] Step 2. Continue stirring and heating. After the temperature is raised to 120-130 °C, stop heating and continue stirring to accelerate the entry of the active ingredients in Pueraria lobata and Polygonatum into sesame oil and sea buckthorn seed oil. Stop stirring when the temperat...

Embodiment 3

[0050] The difference between this example and Example 2 is that the traditional Chinese medicine composition of this example includes: 30g of pueraria, 10g of Polygonatum chinensis, 100g of sesame oil, 100g of sea buckthorn seed oil, 4g of Hericium erinaceus, 3g of chitosan oligosaccharide, and 5g of beeswax.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for protecting gastric mucosa and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight of 30-50 parts of radix puerariae, 10-20 parts of rhizoma polygonati, 100-200 parts of sesame oil, 100-200 parts of seabuckthorn seed oil, 4-10 parts of hericium erinaceus, 3-5 parts of chitosan oligosaccharide and 5-10 parts of beewax, wherein the mass ratio of the sesame oil to the seabuckthorn seed oil is 1 : (0.5-3). According to the invention,the radix puerariae and the rhizoma polygonati are used as main components, the sesame oil and the seabuckthorn seed oil are added according to a certain proportion, total flavonoids are extracted, and the auxiliary materials including the hericium erinaceus, chitosan and the beewax are added to play a synergistic role to prepare an oil mixture, so that the absorption and utilization rate is remarkably increased, and the gastric mucosa is effectively protected. The traditional Chinese medicine composition is prepared into a soft capsule preparation, and the radix puerariae is used as one of components of soft capsule skin, so that the gastric mucosa protection effect can be further improved; and the preparation method is simple, rapid and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for protecting gastric mucosa and a preparation method and application thereof. Background technique [0002] Gastric mucosa is a layer of mucosal tissue that exists in the inner wall of the stomach. It has a special protective effect on the stomach wall. However, the gastric mucosa is very fragile, and its damage and self-repair have always been in a dynamic balance to maintain the normal operation of the stomach. If the stimulation is too strong, it will lead to an imbalance between the aggressive factors and protective / defensive factors of the gastric mucosa, resulting in gastric mucosal damage. Once the gastric mucosa is damaged, it is difficult to recover, resulting in a series of symptoms of stomach discomfort such as upper abdominal discomfort or pain, nausea, vomiting, diarrhea, and loss of appetit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K47/46A61K9/48A61P1/04A61K31/702A61K35/644
CPCA61K36/488A61K36/8969A61K36/185A61K36/07A61K31/702A61K35/644A61K9/4825A61K47/46A61P1/04A61K9/4808A61K2300/00
Inventor 陈小波宋仲华
Owner 生升美高科技(武汉)有限责任公司
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