Selenium-enriched Chinese herbal medicine toothpaste for resisting oral helicobacter pylori

A technology of Helicobacter pylori and Chinese herbal medicine toothpaste, which is applied in antibacterial drugs, oral care, dentistry, etc., can solve the problems of increasing bacterial resistance, increasing drug resistance, and recurrent disease, and achieves effective anti-oral Helicobacter pylori, reduces Biological toxicity, good control effect

Inactive Publication Date: 2021-01-22
SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, a large dose of multiple antibiotics is used to kill Helicobacter pylori at the same time, but this cannot completely kill Helicobacter pylori, but will increase its drug resistance, easily lead to repeated attacks of the disease, and increase the difficulty of treatment
[0005] Toothpaste is a necessary product for people to clean the oral cavity every day. Most of the existing toothpastes have the effect of cleaning the oral cavity and killing bacteria. , the beneficial bacteria are also killed, the micro-ecological environment of the oral cavity is destroyed, and the drug resistance of the bacteria is increased. Therefore, a toothpaste that can resist oral Helicobacter pylori and is healthy and safe has become an urgent problem in this field.

Method used

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  • Selenium-enriched Chinese herbal medicine toothpaste for resisting oral helicobacter pylori
  • Selenium-enriched Chinese herbal medicine toothpaste for resisting oral helicobacter pylori

Examples

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Effect test

Embodiment 1

[0029] A selenium-enriched Chinese herbal medicine toothpaste for resisting oral Helicobacter pylori, comprising the following raw materials in terms of weight percentage: 8wt% of moisturizing agent, 45wt% of friction agent, 2wt% of surfactant, 2wt% of thickener, 2wt% of inorganic selenium, nano 5 wt% of bletilla striata powder, 0.2 wt% of yeast powder, and the balance is deionized water.

[0030] The moisturizing agent described in this embodiment is sorbitol, the friction agent is mesoporous silica for surface modification of cytotoxin-associated gene A (CagA) aptamer, and the surfactant is sodium lauryl sulfate. The thickener is sodium hydroxymethyl cellulose, and the inorganic selenium is sodium selenite.

[0031] The preparation method of selenium-enriched Chinese herbal medicine toothpaste described in the present embodiment comprises the following steps:

[0032] (1) Add water to friction agent, inorganic selenium and nano bletilla striata powder, and mix and stir unde...

Embodiment 2

[0036] A selenium-enriched Chinese herbal medicine toothpaste for resisting oral Helicobacter pylori, comprising the following raw materials in terms of weight percentage: 15wt% of moisturizing agent, 40wt% of friction agent, 5wt% of surfactant, 3wt% of thickener, 2wt% of inorganic selenium, nano 3 wt% of bletilla striata powder and 0.3 wt% of yeast powder, and the balance is deionized water.

[0037] The moisturizing agent described in this embodiment is sorbitol, the friction agent is mesoporous silica for surface modification of cytotoxin-associated gene A (CagA) aptamer, and the surfactant is sodium lauryl sulfate. The thickener is sodium hydroxymethyl cellulose, and the inorganic selenium is sodium selenite.

[0038] The preparation method of selenium-enriched Chinese herbal medicine toothpaste described in the present embodiment comprises the following steps:

[0039] (1) Add water to friction agent, inorganic selenium and nano bletilla striata powder, and mix and stir ...

Embodiment 3

[0043] A selenium-enriched Chinese herbal medicine toothpaste for resisting oral Helicobacter pylori, comprising the following raw materials in terms of weight percentage: 10wt% of moisturizing agent, 30wt% of friction agent, 4wt% of surfactant, 2wt% of thickener, 3wt% of inorganic selenium, nano Bletilla striata powder 3wt%, yeast powder 0.5wt%, and the balance is deionized water.

[0044] The moisturizing agent described in this embodiment is propylene glycol, the friction agent is mesoporous carbon surface-modified cytotoxin-associated gene A (CagA) aptamer, and the surfactant is sodium 2-acyloxy bond sulfonate. The thickener is xanthan gum, and the inorganic selenium is sodium selenite.

[0045] The preparation method of selenium-enriched Chinese herbal medicine toothpaste described in the present embodiment comprises the following steps:

[0046] (1) Add water to friction agent, inorganic selenium and nano bletilla striata powder, and mix and stir under heating to form a...

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Abstract

The invention discloses a selenium-enriched Chinese herbal medicine toothpaste for resisting oral helicobacter pylori, and belongs to the field of toothpaste preparation. The toothpaste comprises thefollowing raw materials of, in percentage by mass, 8 wt%-23 wt% of a humectant, 25 wt%-50 wt% of an abrasive agent, 2 wt%-5 wt% of a surfactant, 1 wt%-3 wt% of a thickener, 1 wt%-3 wt% of inorganic selenium, 2 wt%-5 wt% of nano bletilla striata powder and 0.2 wt%-0.5 wt% of yeast powder, and the balance deionized water. According to the toothpaste, inorganic selenium and nanometer bletilla striatapowder are fully mixed through an organic-inorganic composite technology, the inorganic selenium is organized, efficient biological utilization of the selenium is achieved, meanwhile, the biologicaltoxicity of the inorganic selenium is reduced, and oral helicobacter pylori can be effectively resisted.

Description

technical field [0001] The invention relates to the technical field of toothpaste, in particular to a selenium-enriched Chinese herbal medicine toothpaste against oral Helicobacter pylori. Background technique [0002] Helicobacter pylori (H. pylori, HP) is a Gram-negative spiral-shaped bacterium that was first isolated from a chronic gastritis patient by Warren and Marshall in 1983. Much evidence shows a strong link between gastric and duodenal diseases and Helicobacter pylori. Although Helicobacter pylori is sensitive to many substances in vitro, there are few drugs that are actually effective in clinical use, which may be due to its susceptibility to drug resistance and the special environment of the digestive tract. The drugs used to treat gastric HP infection are mainly antibiotics, bacteriostats, proton pump inhibitors and antisecretory drugs. Because Helicobacter pylori is prone to drug resistance, it is rarely treated with antibiotics or bacteriostats alone. At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/9794A61K8/9728A61Q11/00A61Q17/00A61P1/02A61P11/04A61P31/04
CPCA61K8/19A61K8/9794A61K8/9728A61Q11/00A61Q17/005A61P1/02A61P11/04A61P31/04A61K2800/48
Inventor 朱君吴宁李伟
Owner SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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