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Iodized oil embolism agent containing adriamycin and preparation method of iodized oil embolism agent

A technology of iodized oil and doxorubicin, which is applied in the field of iodized oil embolism containing doxorubicin and its preparation, can solve the problems of developing visibility and embolization effect not very ideal, and achieve improved drug release and material Novel, easy-to-use effects

Inactive Publication Date: 2021-01-22
THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But the present existing lipiodol embolic agent development visibility and embolization effect are not very satisfactory, so, the present invention has designed a kind of lipiodol embolism containing doxorubicin and preparation method thereof

Method used

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  • Iodized oil embolism agent containing adriamycin and preparation method of iodized oil embolism agent
  • Iodized oil embolism agent containing adriamycin and preparation method of iodized oil embolism agent

Examples

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Effect test

Embodiment 1

[0028] Embodiment 1: a kind of lipiodol embolism containing doxorubicin mainly comprises the composite gel powder that mass ratio is 3:1:2, antitumor drug, lipiodol,

[0029] The composite gel powder includes bletilla striata gum, tripropylene gelatin, n-butyl methacrylate and polylactic acid in a mass ratio of 1:3:1:5,

[0030] The anti-tumor drug is loaded inside the composite gel, and the anti-tumor drug is doxorubicin,

[0031] The iodine content of iodized oil is 100mgl / ml.

[0032] A kind of preparation method of lipiodol embolism containing doxorubicin in embodiment 1 mainly comprises the following steps:

[0033] S1: Preparation of composite gel powder

[0034] Add Bletilla striata gum, tripropylene gelatin, n-butyl methacrylate, and polylactic acid into the stirring container according to the proportion, add deionized water of equal mass, preheat the stirring container at a temperature of 38°C for 10 minutes, and then use 2000r / min Stir at a stirring speed for 6 mi...

Embodiment 2

[0039] Embodiment 2: a kind of lipiodol embolism containing doxorubicin, mainly comprises the composite gel powder that mass ratio is 3:1:2, antitumor drug, lipiodol,

[0040] Composite gel powder comprises the composite gel of mass ratio 100:1 and initiator, and composite gel comprises that mass ratio is 1:3:1:5 bletilla striata gum, tripropylene gelatin, n-butyl methacrylate and polylactic acid, initiates The agent is enamide,

[0041] The anti-tumor drug is loaded inside the composite gel, and the anti-tumor drug is adriamycin and mitoxantrone with a mass ratio of 3:1,

[0042] The iodine content of iodized oil is 125mgl / ml.

[0043] A kind of preparation method of lipiodol embolism containing doxorubicin in embodiment 2 mainly comprises the following steps:

[0044] S1: Preparation of composite gel powder

[0045] Add Bletilla striata gum, tripropylene gelatin, n-butyl methacrylate, and polylactic acid into the stirring container according to the proportion, add deionized...

Embodiment 3

[0050] Embodiment 3: a kind of lipiodol embolism containing doxorubicin, mainly comprises the composite gel powder that mass ratio is 3:1:7:2, antitumor drug, magnetic nano material, lipiodol,

[0051] Composite gel powder comprises the composite gel of mass ratio 100:1 and initiator, and composite gel comprises the tripropylene gelatin of the bletilla striata gum that mass ratio is 1:3, and initiator is enamide,

[0052] The anti-tumor drug is loaded inside the composite gel, and the anti-tumor drug is adriamycin and ifosfamide with a mass ratio of 3:2.

[0053] Magnetic nanomaterials are loaded on the outside of the composite gel, and the magnetic nanomaterials are nanometer ferric oxide powder.

[0054] The iodine content of iodized oil is 150mgl / ml.

[0055] A kind of preparation method of lipiodol embolism containing doxorubicin in embodiment 3 mainly comprises the following steps:

[0056] S1: Preparation of composite gel powder

[0057] Add bletilla striata gum and t...

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Abstract

The invention provides an iodized oil embolism agent containing adriamycin and a preparation method of the iodized oil embolism agent. The iodized oil embolism agent is prepared from composite gel powder, an anti-tumor drug and a magnetic nano material and iodized oil; the anti-tumor drug is loaded in composite gel; the magnetic nano material is loaded on the outer side of the composite gel; the preparation method comprises the steps that S1, bletilla striata gelatin, tripropylene gelatin, n-butyl methacrylate, polylactic acid and deionized water are mixed, then initiator alkenyl amide is added, drying and smashing are carried out after a stirring reaction, and composite gel powder is obtained; S2, the anti-tumor drug is added into the composite gel solution, and oscillating and stirring are carried out to obtain drug-loaded gel; S3, the magnetic nano material is dispersed into ultrapure water, a surfactant is added, the drug-loaded microspheres are added, stirring is carried out for reaction, and filtering is performed to obtain magnetic loaded microspheres; and S4, storing and taking are carried out.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a doxorubicin-containing lipiodol embolism and a preparation method thereof. Background technique [0002] At the beginning of the 20th century, iodized oil came out as an X-ray contrast agent and became the first iodine contrast agent used in human organs. With the wide application of iodized oil, medical workers have found that iodized oil also has the effect of arterial embolism, and is the first choice for clinical chemoembolic agents. Iodized oil is a kind of poppy seed oil containing fatty acid ethyl ester, the mass fraction is 37%-41, it is opaque to X-ray, and it is often used as X-ray contrast agent in clinic. Lipiodol can selectively accumulate in the liver cancer tissue area, and at the same time, it has an embolism effect on blood vessels, and is often used as a suspending agent or marker for liver tumor treatment drugs. [0003] Once iodize...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/704A61K41/00A61K47/32A61K47/34A61K47/36A61K47/42A61K49/04A61P35/00
CPCA61K31/704A61K9/02A61K41/00A61K9/0009A61K49/0438A61K47/36A61K47/42A61K47/34A61K47/32A61K9/0019A61P35/00
Inventor 黄智周石曾柱
Owner THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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