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Production equipment and preparation method of high-content polyoxin raw powder

A polyoxin, high-content technology, applied in botany equipment and methods, biocides, biocides, etc., can solve the problems of poor quality of compound pesticide preparations, poor stability of physical and chemical conditions, complex material properties, etc., to achieve anti-bacteria Improve pollution performance, improve spray drying efficiency, and reduce the effect of macromolecular organic matter content

Inactive Publication Date: 2021-02-02
陕西麦可罗生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the production process, the properties of the material are complex, and the stability of the physical and chemical conditions is poor. At the same time, due to the high sugar content in the material, it is very easy to be infected with yeast. The current production method is relatively extensive. After the fermentation broth is compatible or the plate and frame filtrate is concentrated, spray drying Or granulation, the material has strong contactability, the control index in the process is simple, the appearance of the product is poor, and it is easy to degrade after long-term storage, and the quality of the produced preparations, water agents, and compound pesticides is poor
Therefore, the process of the prior art is relatively extensive, and the content and storage quality stability of the obtained polyoxin raw powder all need to be further improved urgently.

Method used

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  • Production equipment and preparation method of high-content polyoxin raw powder
  • Production equipment and preparation method of high-content polyoxin raw powder
  • Production equipment and preparation method of high-content polyoxin raw powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050]1) There is no need to inactivate after the fermentation, the circulating water is cooled to 25℃±2℃, the materials are sent to the acidification tank, acidified with oxalic acid to pH 3.0, stand for 2h~3h, and the intermediate control temperature is 20℃~25℃.

[0051]2) The material is filtered through a plate and frame, and the clear liquid is collected. The filter cake is top washed with 10%~15% of the fermentation broth volume without salt water. The filtration time is controlled within 6h~12h, and the clear liquid content is 2500mg / L~3000 mg / L. 0.3g / L sodium bisulfite was added to the filtrate.

[0052]3) Ultrafiltration membrane treatment: the filtrate enters the ultrafiltration membrane for filtration. The ultrafiltration membrane selects a ceramic membrane with a molecular weight cut-off of 10000Da. The inlet pressure is 0.035MPa~0.040MPa, and the pressure behind the membrane is 0.015MPa~0.02MPa. Collect the clear liquid and the late concentrated liquid. Replenish an appropria...

Embodiment 2

[0061]1) After the fermentation, there is no need to inactivate, the circulating water is cooled to 25℃, the materials are sent to the acidification tank, and the pH is acidified with oxalic acid to 4.0, and then left for 2h~3h. The intermediate control temperature is 20℃~25℃.

[0062]2) The material is filtered through a plate and frame, and the clear liquid is collected. The filter cake is top washed with 10%~15% of the fermentation broth volume without salt water. The filtration time is controlled within 6h~12h, and the clear liquid content is 2500mg / L~3000 mg / L. Add 0.3-0.5g / L of sodium bisulfite and sodium metabisulfite mixture (configured in a 2:1 mass ratio) to the filtrate.

[0063]3) Ultrafiltration membrane treatment: the filtrate enters the ultrafiltration membrane for filtration. The ultrafiltration membrane selects a ceramic membrane with a molecular weight cut-off of 10000Da. The inlet pressure is 0.035MPa~0.040MPa, and the pressure behind the membrane is 0.015MPa~0.02MPa. C...

Embodiment 3

[0072]1) After the fermentation, there is no need to inactivate, the circulating water is cooled to 25℃, the materials are transferred to the acidification tank, and the pH is acidified with oxalic acid to 3.5. After the acidification, the potency is 3000mg / L~4000mg / L, standing for 2h~3h, intermediate control The temperature is 20℃~25℃.

[0073]2) The material is filtered through a plate and frame, and the clear liquid is collected. The filter cake is top washed with 10-15% of the fermentation broth volume without salt water. The filtering time is controlled at 6-12h, and the clear liquid content is 2500-3000 mg / L, and the filtrate is added 0.3~0.5g / L sodium metabisulfite.

[0074]3) Ultrafiltration membrane treatment: the filtrate enters the ultrafiltration membrane for filtration. The ultrafiltration membrane selects a ceramic membrane with a molecular weight cut-off of 10,000 Daltons. The inlet pressure is 0.035~0.040MPa, and the pressure behind the membrane is 0.015~0.02MPa. The clear...

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Abstract

The invention relates to production equipment and a preparation method of high-content polyoxin raw powder. The preparation method comprises the following steps: filtering acidified polyoxin fermentation liquor through a plate frame, treating the plate frame filtrate through an ultrafiltration membrane, adding calcium chloride into the ultrafiltration membrane to carry out protein coagulation, carrying out decolorization membrane treatment, and carrying out concentration and dialysis treatment in a nanofiltration membrane, and finally, carrying out activated carbon static adsorption treatmenton the concentrated solution, and carrying out spray drying to generate high-content polyoxin raw powder. According to the method, an ultrafiltration membrane, a decolorization membrane and a nanofiltration membrane are used for continuously separating the polyoxin filtrate, and finally, activated carbon is used for refining separation so that the content of the produced polyoxin raw powder reaches 34.0% or above, the appearance of the raw medicine is white or off-white, and the breakthrough of the quality of the raw powder can generate beneficial factors on the production quality stability ofdownstream preparations; meanwhile, the technical bottleneck of development of high-content dosage forms and compound dosage forms of pesticide preparations in the next step is solved.

Description

Technical field[0001]The invention belongs to the technical field of downstream separation of fermentation products, and specifically relates to a production equipment and a preparation method of high-content polyoxin powder.Background technique[0002]Polyoxin is a class of multi-component antibiotics with very similar structures. The metabolites produced by Streptomyces aureus belong to the broad-spectrum antibiotic fungicide. A mixture of 14 different homologues from A to N, which are peptide pyrimidine nucleotide antibiotics. It has good systemic conduction. Its mechanism of action is to interfere with the biosynthesis of chitin in the cell wall of the bacteria, so that the cell wall of the bacteria cannot be biosynthesized and the bacteria die. After the germ tube and mycelium come into contact with the medicament, they locally swell, rupture, overflow the cell content, and fail to develop normally, leading to death, and it has the effect of inhibiting the spore production of pat...

Claims

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Application Information

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IPC IPC(8): A01N47/12A01N25/12A01P3/00A01P1/00
CPCA01N25/12A01N47/12
Inventor 马文艳王卫富郭秀艳潘忠成翁婧李蒲民
Owner 陕西麦可罗生物科技有限公司
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