Preparation method of selenium nano double-emulsified micro-preparation
A selenium nano- and double-emulsion technology, which is applied in the direction of anti-toxic agents, pharmaceutical formulas, emulsion delivery, etc., can solve the problems of inability to accurately control the absorption and release properties, and achieve the effects of enriching nutrition, inducing apoptosis, and facilitating preservation
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[0040]A preparation method of selenium nano double-emulsified micro-preparation with slow-release characteristics, nutritional supplement and cancer cell inhibition function, including the following steps:
[0041]1) Using chitosan as a template, prepare the W1 phase of the chitosan-selenium nano preparation;
[0042]2) Add the chitosan-selenium nano-preparation W1 phase obtained in step (1) to the O-phase container containing soybean oil-vitamin E, and perform high-pressure homogenization to form a W1 / O colostrum;
[0043]3) Adjust the pH of the W1 / O colostrum prepared in step (2) and add it to the W2 composite solution of the polysaccharide-whey protein stock solution to prepare a W1 / O / W2 double emulsion.
Example Embodiment
[0044]Example 1 Preparation of chitosan-selenium (W1 phase) of the present invention
[0045]Use Vc to restore H in situ2SeO3Method, that is, 0.01g~10g chitosan gum is dissolved in 50mL ultrapure water, stirred with a magnetic stirrer at a speed of 100~1000r / min, after stirring for 0~48h, slowly add 1~50mL, 0.1~50mM / L Selenite solution, after reacting for 1h, add 1-50mL, 1-100mmol / L Vc solution, stir well until the solution turns bright orange-red. Then dilute the orange-red solution to 100~500mL and continue to stir it fully for 1~36h, then store it in the refrigerator at -20~10℃.
Example Embodiment
[0046]Example 2 Preparation of the selenium micro-nano double emulsification preparation of the present invention
[0047]1. Prepare whey protein stock solution with a concentration of 1%-30% (w / w): whey protein powder is dissolved in water, and after magnetic search for 2 hours at room temperature, it is allowed to stand overnight at 4°C to ensure completeness Dissolve and hydrate. Equilibrate to room temperature the next day and heat it in a water bath at 80°C for 30 minutes to fully denature it. A gum arabic solution with a concentration of 0.5% to 5% (w / w) is prepared. The concentrations of whey protein isolate and pectin stock solutions were prepared at 10% and 2% respectively.
[0048]2. Preparation of polysaccharide and protein mixing system: mix the polysaccharide and whey protein isolate solution in a certain volume ratio and continue to gently magnetically stir. The concentration of whey protein isolate in the final mixed system is fixed at the mixing quality of gum arabic and w...
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