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Compound probiotic for inhibiting vaginitis and product and application of compound probiotic

A technology of compounding probiotics and inflammation, applied in the directions of medical preparations containing active ingredients, antibacterial drugs, antifungal agents, etc., can solve the problems of adverse reactions, incomplete treatment, high recurrence rate, and achieve the effect of inhibiting inflammation.

Active Publication Date: 2021-02-26
INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The clinical treatment of vaginitis is mainly based on the combination of vaginal lavage and antibacterial drugs, and imidazoles, clindamycin hydrochloride and compound preparations are often used. However, the above drugs will cause many adverse reactions, leading to drug resistance of pathogenic bacteria Gradually strengthened, has the disadvantages of high recurrence rate, imbalance of microecology in the internal environment, and incomplete treatment

Method used

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  • Compound probiotic for inhibiting vaginitis and product and application of compound probiotic
  • Compound probiotic for inhibiting vaginitis and product and application of compound probiotic
  • Compound probiotic for inhibiting vaginitis and product and application of compound probiotic

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1 Compound probiotic fermentation base and antibacterial substances after fermentation (organic acids and short-chain fatty acids)

[0038] The raw materials were uniformly mixed with distilled water at 55°C according to Table 1, homogenized, sterilized and cooled, and then fermented at a constant temperature of 37°C to pH=4.50, and then sterilized at 85°C for 15 minutes for later use, namely PFB gel.

[0039] Table 1 Base material fermentation ratio and details of probiotic inoculation amount

[0040]

[0041] Wherein, the content percentages of skim milk powder, full-fat soybean powder and distilled water are calculated based on the sum of the weights of the three; the inoculation concentrations of Lactobacillus casei Zhang, Lactobacillus rhamnosus Probio-M9 and Lactobacillus plantarum P-8 are based on The total volume of the combination of skim milk powder, full fat soy flour, and distilled water was calculated.

[0042] The fermented liquid ...

experiment example 2

[0045] Experimental Example 2 Clinical effect and changes of vaginal flora by adding probiotic fermentation liquid gel in the treatment of vaginitis

[0046] 1. Preparation of Probiotic Ferment Broth Gel

[0047] Use citric acid to adjust deionized water (79.45%) to pH=4.50, add (0.5%) Carbopol 940 and stir until it dissolves evenly, continue to add triethanolamine (1.5%) and stir evenly, add propylene glycol (2.5%), PEG-90M (0.05%), moisturizing gel (5.0%), phenoxyethanol (1.0%) and the probiotic fermentation broth (10.0%) prepared in Experimental Example 1, stirred evenly, and carried out sample preparation with 3g / branch, Wherein, the ratio of each component is the weight percentage based on the total weight of the probiotic fermentation liquid gel.

[0048] 2. Experimental objects and methods of use

[0049] The subjects were 50 vaginitis women (aged 18-55 years old) who visited the Obstetrics and Gynecology Clinic of Kunming Tongren Hospital from January 2020 to March...

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Abstract

The invention discloses a compound probiotic for inhibiting vaginitis and a product and application of the compound probiotic. The compound probiotic comprises Lactobacillus casei Zhang, Lactobacillusrhamnosus Probio-M9 and Lactobacillus plantarum P-8. The compound probiotic and the product thereof can prevent, relieve, inhibit and / or treat inflammatory response, have the effect of resisting vaginitis, and can be used for treating vaginitis or preparing drugs for treating vaginitis.

Description

technical field [0001] The application belongs to the field of biotechnology, and in particular relates to a compound probiotic for inhibiting vaginal inflammation and its products and applications. Background technique [0002] The microorganisms in the vagina of healthy women are mainly Lactobacillus to maintain a normal acidic environment. Under normal circumstances, the pH of the vagina of healthy women is lower than 4.50, which has a "vaginal self-cleaning effect" in this environment. However, the self-purification of the vagina in patients with vaginitis is destroyed, the relative abundance of pathogenic bacteria increases, excessive consumption of glycogen inhibits the fermentation of lactobacilli, and the acidic environment of the vagina is changed to neutral or alkaline, resulting in bacteria such as Escherichia coli, white Pathogens such as Candida and Staphylococcus aureus proliferate, and related inflammatory responses include bacterial vaginosis, candidal vagin...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P15/02A61P31/04A61P31/10A61P33/02
CPCA61K35/747A61P15/02A61P31/04A61P31/10A61P33/02A61K2300/00Y02A50/30
Inventor 刘晓军其木格苏都张凌宇包维臣
Owner INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD