Streptococcus suis vaccine recombinant protein GSE and preparation method and application thereof

A recombinant protein, Streptococcus suis technology, which is applied in the biological field to achieve the effect of good practicability and efficient preparation
CN112410310AInactive Publication Date: 2021-02-26TIANJIN AGRICULTURE COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN AGRICULTURE COLLEGE
Publication Date
2021-02-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a recombinant protein GSE used as a streptococcus suis vaccine. The amino acid sequence of the recombinant protein is SEQ ID NO. 1. Aiming at the problems that the cross protection effect between an inactivated vaccine and a low virulent vaccine of streptococcus suis is poor, and certain biosecurity exists, the recombinant protein designed on the basis of screening of streptococcus suis protective antigen epitopes can be used for preparing the streptococcus suis vaccine. The recombinant protein can be efficiently prepared under the safe condition and has good practicability.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, in particular to a Streptococcus suis vaccine recombinant protein GSE and its preparation method and application. Background technique

[0002] Streptococcus suis (Streptococcus suis) is a very important bacterial infectious disease pathogen for the pig industry. If an epidemic occurs, it may cause huge economic losses. Streptococcus suis can cause meningitis, arthritis, sepsis, Diseases such as endocarditis, encephalitis, miscarriage, multiple serositis, and bronchopneumonia have a mortality rate as high as 80%. Large-scale outbreaks occurred in my country in 1990 and 2005, which once again reminded people to pay more attention to the disease.

[0003] Due to the large number of serotypes of Streptococcus suis, the inter-type cross-protection effect of inactivated vaccines is not good in the preventive stage of this disease. The current vaccine research is more inclined to the development of subun...

Claims

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