Drug-loaded microsphere-microneedle array with controllable drug delivery, and preparation method and application thereof
A technology of drug-loaded microspheres and microneedle arrays, applied in the directions of microneedles, pharmaceutical formulations, and drug devices, can solve the problems of limiting the application of drug-loaded microspheres, uneven distribution of microspheres, poor patient compliance, etc. The distribution is uneven and easy to fall off, and the effect of controlled release and accelerated release can be realized.
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[0033] A method for preparing a drug-loaded microsphere-microneedle array with controllable administration, comprising the following steps:
[0034] S1. Preparation of drug-loaded microspheres
[0035] The drug is mixed with the hydrogel to prepare the hydrogel and the drug mixed solution as the internal phase. The hydrogel is composed of black phosphorus (BP), N-isopropylacrylamide (NIPAM), acrylamide (AAM) The external phase is an oil phase immiscible with the internal phase. The external phase and the internal phase are injected into the microfluidic device, and the shear force between the two-phase solutions is used to form monodisperse single-emulsion droplets. The flow rate of the fluidic inner phase and the outer phase changes the droplet size; solidify and collect, rinse with alcohol and deionized water several times to obtain polymer drug-loaded microspheres with uniform particle size (diameter between 200-500 μm); The hydrogel of drug microspheres is made by mixing ...
Embodiment 1
[0038] Example 1——Preparation of drug-loaded microsphere-microneedle arrays with controlled administration
[0039] S1. Preparation of drug-loaded microspheres
[0040] The microfluidic device was prepared by capillary with an outer diameter of 1 mm and an inner diameter of 500 μm. The inner phase tube was machine-drawn and ground into the required diameter, the outer phase tube was treated with octadecyltrimethoxysilane for hydrophobic treatment, and the inner and outer phase tubes were assembled coaxially. ; The internal phase tube is connected with 15% NIPAM, 0.2% BP, 0.9% AAM solution, 0.2 IU insulin and 1% photoinitiator mixed solution, the external phase tube is connected with sunflower oil, and the flow rate of the internal and external phases is controlled by a peristaltic pump to control the droplet size; The single emulsion droplets produced were irradiated vertically with ultraviolet light for 30 s and collected, and then washed 3 times with absolute ethanol and ult...
Embodiment 2
[0043] Example 2——Preparation of drug-loaded microsphere-microneedle arrays with controlled administration
[0044] S1. Preparation of drug-loaded microspheres
[0045] The microfluidic device was prepared by capillary with an outer diameter of 1 mm and an inner diameter of 500 μm. The inner phase tube was machine-drawn and ground into the required diameter, the outer phase tube was treated with octadecyltrimethoxysilane for hydrophobic treatment, and the inner and outer phase tubes were assembled coaxially. ; The internal phase tube is connected with 10% NIPAM, 0.5% BP, 1.2% AAM solution, 0.2 IU insulin and 1% photoinitiator mixed solution, the external phase tube is connected with sunflower oil, and the flow rate of the internal and external phases is controlled by a peristaltic pump to control the droplet size; The single emulsion droplets produced were irradiated vertically with ultraviolet light for 30 s, and then washed 3 times with absolute ethanol and ultrapure water f...
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