A skull repair plate with composite structure

A composite structure and plate technology, which is applied in the fields of polymer materials and biomedical engineering, can solve the problems of large difference in strength and weaken the mechanical strength of PEEK, and achieve the effect of promoting osteogenic differentiation

Active Publication Date: 2021-12-07
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, skull repair materials play a role in supporting and protecting brain tissue, and at the same time resist external blows. They need sufficient mechanical strength, and the mechanical strength of PEEK porous scaffolds is quite different from that of bone tissue.
[0004] Chinese patent CN 103549990 A discloses a PEEK cranial repair mesh plate, which is integrally injection molded according to the patient's skull condition, and its thickness can be maintained between 0.6-2mm, and the connecting ribs between the holes are guaranteed to be within the range of 0.5-0.8mm; The mechanical strength of pure PEEK material is similar to that of human bone tissue. Although it has a good pore structure, the PEEK grid structure greatly weakens the mechanical strength of PEEK.

Method used

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  • A skull repair plate with composite structure
  • A skull repair plate with composite structure
  • A skull repair plate with composite structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of spherical porogen: prepare 10g of glutinous rice flour and 2g of water into a paste, add vegetable oil, add 50g of NaCl crystal particles with a particle size of 70 mesh, stir with a stirrer at 1000 rpm for 5 minutes, and heat the oil to 80°C , After the stirring is completed, the spherical sodium chloride particles are then sieved from the oil, washed in isopropanol, dried, and then sieved to obtain spherical sodium chloride with a particle size of 600 μm.

[0029] Preparation of powder: pure polyetheretherketone material is the raw material for the middle solid structure and reinforcing ribs; spherical sodium chloride particles and polyetheretherketone powder are mixed in a ratio of 3:7 as the raw material for the outer ring porous body.

[0030] Molding: The powder pressing molding method is adopted. First, the middle solid part and 6 ribs are pressed into a flat plate, and the porous body powder is filled; then sintered at a temperature of 380 ° C for ...

Embodiment 2

[0034] Preparation of spherical porogen: prepare 10g of glutinous rice flour and 2g of water into a paste, add vegetable oil, add 50g of NaCl crystal particles with a particle size of 70 mesh and 50 mesh, stir with a stirrer at 1000 rpm for 5 minutes, and simultaneously heat the oil to After heating at 80°C and stirring, the spherical sodium chloride particles were then sieved from the oil, washed in isopropanol, dried, and then sieved to obtain spherical sodium chloride with a particle size of 600 μm and 200 μm.

[0035] Preparation of powder: pure polyether ether ketone material is the raw material for the intermediate solid structure and reinforcing ribs; the spherical sodium chloride particles of 600 μm and the spherical sodium chloride particles of 200 μm are respectively mixed with polyether ether ketone powder in a ratio of 3:7 Raw materials for the porous body of the outer ring were mixed.

[0036] Molding: Using powder pressing molding method, the middle solid part an...

Embodiment 3

[0041] Preparation of spherical porogen: prepare 10g of glutinous rice flour and 2g of water into a paste, add vegetable oil, add 50g of NaCl crystal particles with a particle size of 70 mesh, stir with a stirrer at 1000 rpm for 5 minutes, and heat the oil to 80°C , After the stirring is completed, the spherical sodium chloride particles are then sieved from the oil, washed in isopropanol, dried, and then sieved to obtain spherical sodium chloride with a particle size of 600 μm.

[0042] Preparation of powder: pure polyetheretherketone material has a solid structure in the middle; spherical sodium chloride particles and polyetheretherketone powder are mixed at a ratio of 3:7 as the raw material of the outer ring porous body.

[0043] Molding: The powder pressing molding method is adopted, the solid part in the middle is first pressed into a flat plate, and the powder of the porous body is filled; then sintering is carried out at a temperature of 380°C for 1 hour.

[0044] Bend...

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Abstract

The invention provides a skull repair plate with a composite structure and a preparation method thereof, wherein the skull repair plate with a composite structure of the present invention is composed of a central entity and an outer porous body, and the central entity can ensure that the repair material has sufficient mechanical properties Resist external shocks; the porous body in the outer ring has a pore structure that gradually changes from outside to inside. The large pore structure on the periphery is conducive to guiding the inward growth of cells, and the smaller pore structure inside can make cells aggregate and promote osteogenic differentiation. Long-term fixation of the skull plate.

Description

technical field [0001] The invention relates to the fields of polymer materials and biomedical engineering, in particular to a skull repair plate with a composite structure and a preparation method thereof. Background technique [0002] Polyetheretherketone (poly-ether-ether-ketone, PEEK) is one of the polyaryletherketone polymers. Due to its good mechanical properties, chemical properties and biocompatibility, PEEK was the first to be used in orthopedics, trauma One of the thermoplastics in medicine. As the material closest to human bones, PEEK is gradually used in skull repair. PEEK has the following three advantages as a skull repair material: first, it is non-magnetic and will not produce artifacts on CT or MRI; second, PEEK material The modulus of elasticity is closer to that of human bones, and the weight is lighter. It is more comfortable to implant in the patient's body; finally, PEEK has good thermal insulation and will not damage the brain tissue. [0003] Howeve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61L31/00A61L31/02A61L31/06A61L31/14
CPCA61F2/0063A61F2/2875A61F2002/3079A61F2002/3093A61L31/005A61L31/028A61L31/06A61L31/14A61L2300/30C08L61/16
Inventor 张海军刘黎明鲁手涛侯文博周超尹玉霞袁坤山
Owner SHANDONG BRANDEN MEDICAL DEVICE
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