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Seaweed composite polysaccharide composition and preparation method and application thereof

A technology of complex polysaccharides and seaweed polysaccharides, which is applied in the field of medicine, can solve the problems of difficult extraction, separation and purification of lentinan, difficulty in monitoring quality standards, high price, etc., and achieve the effects of enhancing immunity, convenient administration, and rapid dissolution

Inactive Publication Date: 2021-03-26
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction, separation and purification of lentinan is difficult, the yield is low, the molecular weight is high, the solubility is poor, the quality standard is difficult to monitor, and the price is expensive, which brings huge economic pressure to cancer patients.

Method used

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  • Seaweed composite polysaccharide composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Seaweed complex polysaccharides were prepared according to the following method.

[0032] The extraction method of seaweed polysaccharide in carrageenan is as follows:

[0033] 1) Take 3 kg of carrageenan, soak it, wash it, put it in hot water at 90±5°C, blanch it for 25 minutes, and set aside;

[0034] 2) Add carrageenan treated in step 1) to 25kg of 20% ethanol solution, add 500g of sodium carbonate and 15g of Tween 40, extract at 50°C for 3 hours, and filter to obtain the filtrate;

[0035] 3) Add 30kg of 30% ethanol solution to the filtrate obtained in step 2), stir, mix for 20min, filter to obtain clear liquid;

[0036] 4) Decolorize, purify, and dry to obtain carrageenan polysaccharide extract.

[0037] The extraction method of seaweed polysaccharide in kelp is as follows:

[0038] 1) Take 7kg of kelp, dry it, crush it, soak it in 20% ethanol solution, stir it, and dry it to get defatted kelp powder;

[0039] 2) Add the kelp powder treated in step 1) into wate...

Embodiment 2

[0051] The preparation method of embodiment 2 seaweed compound polysaccharide sheet

[0052] Take 10 g of the seaweed composite polysaccharide raw material in Example 1, 0.6 g of hydroxypropyl methylcellulose, 1 g of tartaric acid, and add purified water to make a slurry for later use; after dry mixing 12 g of cornstarch and 17 g of microcrystalline cellulose, slowly add the slurry, For soft materials, granulate with 18-mesh sieve. Dry the granules at 50°C to 65°C, sieve through a 14-mesh sieve, add 10g of pregelatinized starch, and mix. Sampling, after passing the inspection, tableting, packaging, and storage after passing the inspection.

[0053] The preparation method of embodiment 2 seaweed composite polysaccharide particles

[0054] Take 10 g of the seaweed composite polysaccharide raw material in Example 1, 0.6 g of hydroxypropyl methylcellulose, 1 g of tartaric acid, and add purified water to make a slurry for later use; after dry mixing 12 g of cornstarch and 17 g of...

Embodiment 3

[0055]The preparation method of embodiment 3 seaweed composite polysaccharide capsule

[0056] Take 10 g of the seaweed composite polysaccharide raw material in Example 1, 0.6 g of hydroxypropyl methylcellulose, 1 g of tartaric acid, and add purified water to make a slurry for later use; after dry mixing 12 g of cornstarch and 17 g of microcrystalline cellulose, slowly add the slurry, For soft materials, granulate with 18-mesh sieve. Dry the granules at 50°C to 65°C, sieve through a 14-mesh sieve, add 10g of pregelatinized starch and mix them. Sampling, after passing the inspection, packing, polishing, packaging, and putting into storage after passing the inspection.

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Abstract

The invention provides a seaweed composite polysaccharide composition and a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method is simple in process and stable in medicine, and has the advantages of rapid dissolution, rapid absorption, high bioavailability, convenience in taking and the like. The traditional Chinese medicine composition can enhance immunity and effectively resist tumors.

Description

technical field [0001] The invention provides a seaweed composite polysaccharide composition and its preparation method and application, belonging to the technical field of medicine. The invention has the advantages of simple process, stable drug, rapid dissolution, fast absorption, high bioavailability, convenient administration and the like. The invention can enhance immunity and effectively fight tumors. Background technique [0002] Seaweed is one of the most abundant resources in the world, especially large brown algae such as kelp and wakame, which have been successfully cultivated artificially, and the output has greatly increased. In recent years, the research on fucoidan, the extract of brown algae, has gradually increased. Fucoidan is an intercellular viscous polysaccharide that is difficult to digest and absorb, mainly including alginic acid, fucoidan, sulfated polysaccharide in brown algae, agar and carrageenan in red algae, etc. Polysaccharides are important ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P37/04A61P35/00
CPCC08B37/0003A61K31/715A61P37/04A61P35/00
Inventor 陈阳生孙桂玉刘晓霞臧云龙王明刚刘振玉沈鑫刘薇汪泓
Owner CP PHARMA QINGDAO CO LTD
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