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Medicine for treating artery-related diseases and application thereof

A technology of use and medicine, applied in the direction of drug combination, cardiovascular system diseases, medical raw materials derived from ferns/filamentous plants, etc.

Active Publication Date: 2021-03-30
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clinically, there is no preventive and therapeutic drug for aneurysm, intramural hematoma, and arterial dissection. Except for surgical treatment, the patient is in a state of no cure.

Method used

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  • Medicine for treating artery-related diseases and application thereof
  • Medicine for treating artery-related diseases and application thereof
  • Medicine for treating artery-related diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0185] Preparation of aneurysm, intramural hematoma, and arterial dissection models

[0186] The mice were anesthetized by intraperitoneal injection of 1% sodium pentobarbital at a dose of 20 mg / kg according to the body weight of the mice. After waiting for the mouse to enter the anesthesia state, the abdominal hair was shaved off with a razor, and the hair was further thoroughly depilated with a depilatory cream. After the abdomen was wiped clean, it was fixed on the operating table, and a heating pad was used under the body to maintain body temperature. After wiping the skin of the abdomen with iodine, deiodine with 75% ethanol, cut an incision of about 1.5 cm in the center of the abdomen, carefully push away the viscera with forceps, and then divide the intestinal tract with gauze moistened with 3% penicillin-streptomycin. To the left and right sides, use forceps to carefully separate the connective tissue and muscle tissue on the surface of the aorta, so that the abdominal...

Embodiment 1

[0203] Preventive and therapeutic effect of ferulic acid on aneurysm, intramural hematoma and arterial dissection

[0204] (1) The preventive and therapeutic effect of ferulic acid on aneurysm

[0205] Animal administration and grouping: 30 8-week-old C57BL / 6 mice entered the animal room to adapt to feeding for one week, and then were randomly divided into normal control group, model control group and ferulic acid group (n=10 in each group), pig pancreas The day of elastase-induced aneurysm operation was Day 0. From the fifth day, animals were given normal saline or ferulic acid by intraperitoneal injection. The dosage of ferulic acid was 20 mg / kg, and the administration After 10 days, the animal's activities were closely observed. On the 15th day, after the animal was euthanized, arterial tissue was obtained to evaluate the expansion of the aneurysm.

[0206] Experimental results and analysis:

[0207] Experimental results such as figure 1 As shown in A-C, it can be seen t...

Embodiment 2

[0212] Preventive and therapeutic effect of piperazine ferulate (oral administration) on aneurysm, intramural hematoma and arterial dissection

[0213] Animal administration and grouping situation: 30 8-week-old C57BL / 6 mice entered the animal room to adapt to feeding for one week, and then were randomly divided into normal control group, model control group and piperazine ferulate group (n=10 in each group), Pig pancreatic elastase and 1% β-aminopropionitrile were fed to induce intramural hematoma and arterial dissection. The day of operation was defined as day 0, and animals were given 0.5% carboxymethyl by gavage from the fifth day. Sodium cellulose or piperazine ferulate, the administration dose of piperazine ferulate is 50 mg / kg, continuous administration for 10 days and the activity of the animals are closely observed, and the aortic tissue is obtained after euthanizing the animals on the 15th day Evaluate for intramural hematoma and arterial dissection.

[0214] Experime...

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Abstract

The invention provides a medicine for treating artery-related diseases and an application thereof. Specifically, the invention provides an application of the compound shown in the formula I in treating artery related diseases. Experiments show that the compound shown in the formula I has a remarkable curative effect on arterial lesions such as aneurysm, interwall hematoma and / or arterial dissection.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to medicaments for treating arterial-related diseases and applications thereof. Background technique [0002] Aneurysm, intramural hematoma, and arterial dissection are interrelated and independent diseases that can occur in thoracic aorta, abdominal aorta, splenic artery, hepatic artery, superior mesenteric artery, celiac artery, renal artery, omental artery, Inferior mesenteric artery, intracranial artery and carotid artery etc. The development of these diseases all lead to blood vessel rupture in the later stage, endangering the patient's life. The etiology of aneurysm, intramural hematoma and arterial dissection is very complex, and smoking, hypertension and atherosclerosis are the most common inducing factors. It is characterized by degradation of extracellular matrix in the media and adventitia, thinning of the arterial wall, and invasion of inflammatory cells. As the...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/192A61K31/37A61K31/085A61K35/644A61K36/534A61K36/23A61K36/232A61K36/11A61K36/236A61K36/71A61K36/725A61K36/287A61K36/61A61K36/53A61K36/70A61K36/185A61K36/234A61K36/85A61K36/537A61K36/63A61K36/282A61K36/83A61K36/748A61K36/258A61K36/39A61K36/43A61K36/52A61K36/75A61K36/9062A61K36/575A61K36/88A61K36/328A61K36/738A61K36/74A61K36/54A61K36/899A61K36/535A61K36/8962A23L33/00A61P9/14
CPCA61K31/216A61K31/192A61K31/37A61K31/085A61K35/644A61K36/534A61K36/23A61K36/232A61K36/11A61K36/236A61K36/71A61K36/725A61K36/287A61K36/61A61K36/53A61K36/70A61K36/185A61K36/234A61K36/85A61K36/537A61K36/63A61K36/282A61K36/83A61K36/748A61K36/258A61K36/39A61K36/43A61K36/52A61K36/75A61K36/9062A61K36/575A61K36/88A61K36/328A61K36/738A61K36/74A61K36/54A61K36/899A61K36/535A61K36/8962A23L33/00A61P9/14A23V2002/00A61K2300/00A23V2200/326A61P9/00A61K31/05A61K31/343A61K31/12
Inventor 姜宝红张娴静丁玉超翟紫怡
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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